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 Chemical Synapses (AG Gundelfinger)

 Weaving the matrix: Perineuronal nets and synaptic plasticity

The perineuronal nets of the extracellular matrix surround many neurons in the brain. They are formed during maturation of the nervous system. These nets envelop and insulate neuronal somata and synaptic contact sites (Fig 1) . The neural proteoglycans brevican and neurocan are components of perineuronal nets. Brevican/neurocan deficiency in knock out animals has several consequences for plastic properties of the mouse brain, however, the mode of action of extracellular matrix components on synaptic transmission and plasticity is still hypothetical (Fig. 2).

Figure 1 : Caught in the net: Brevican-containing perineuronal nets (green) surround Bassoon-positive synaptic contacts (red).

Figure 2 : Matrix matters: perisynaptic proteoglycan nets can influence synaptic function in different ways (G, perisynaptic glia producing proteoglycans; GF, growth factors).

Our group studies proteoglycan-interacting molecules, the development of perineuronal nets in neural culture systems, the proteoglycan deficiency phenotype in knock out mice and cognitive consequences of polymorphisms in the human proteoglycan genes.

Collaborators in the project:

The Brevicanos: Nora John, Björn Schott, Constanze Seidenbecher, Renato Frischknecht (from left to right; sculpture by Volker Kiehn).

  • Constanze Seidenbecher
  • Daniel Fischer
  • Renato Frischknecht
  • Nora John
  • Björn Schott (Neurology II, OvGU Magdeburg)

External collaborations:

Selected publications:

Held-Feindt J, Paredes EB, Blomer U, Seidenbecher C, Stark AM, Mehdorn HM, Mentlein R (2006) Matrix-degrading proteases ADAMTS4 and ADAMTS5 (disintegrins and metalloproteinases with thrombospondin motifs 4 and 5) are expressed in human glioblastomas. Int J Cancer 118(1):55-61.[Link]

John N, Krugel H, Frischknecht R, Smalla KH, Schultz C, Kreutz MR, Gundelfinger ED, Seidenbecher CI (2006) Brevican-containing perineuronal nets of extracellular matrix in dissociated hippocampal primary cultures. Mol Cell Neurosci 31(4):774-784.[Link]

Brakebusch C, Seidenbecher CI, Asztely F, Rauch U, Matthies H, Meyer H, Krug M, Boeckers TM, Zhou X, Kreutz MR, Montag D, Gundelfinger ED, Fassler R (2002) Brevican-deficient mice display impaired hippocampal CA1 long-term potentiation but show no obvious deficits in learning and memory. Mol Cell Biol 22(21):7417-7427.[Link]

Seidenbecher CI, Smalla KH, Fischer N, Gundelfinger ED, Kreutz MR (2002) Brevican isoforms associate with neural membranes. J Neurochem 83(3):738-746.[Link]

Zhou XH, Brakebusch C, Matthies H, Oohashi T, Hirsch E, Moser M, Krug M, Seidenbecher CI, Boeckers TM, Rauch U, Buettner R, Gundelfinger ED, Fassler R (2001) Neurocan is dispensable for brain development. Mol Cell Biol 21(17):5970-5978.[Link]

Brueckner G, Grosche J, Schmidt S, Hartig W, Margolis RU, Delpech B, Seidenbecher CI, Czaniera R, Schachner M (2000) Postnatal development of perineuronal nets in wild-type mice and in a mutant deficient in tenascin-R. J Comp Neurol 428(4):616-629.

Seidenbecher CI, Gundelfinger ED, Bockers TM, Trotter J, Kreutz MR (1998) Transcripts for secreted and GPI-anchored brevican are differentially distributed in rat brain. Eur J Neurosci 10(5):1621-1630.[Link]

Rauch U, Meyer H, Brakebusch C, Seidenbecher C, Gundelfinger ED, Beier DR, Fassler R (1997) Sequence and chromosomal localization of the mouse brevican gene. Genomics 44(1):15-21.

Seidenbecher C, Richter K, Gundelfinger ED (1997) Brevican, a conditional proteoglycan from rat brain: characterization of secreted and GPI-achored isoforms. In: Neurochemistry (Teelken AW, Korf J, eds), pp 901-904. New York, London, Washington D.C., Boston: Plenum Press.[Link]

Seidenbecher CI, Richter K, Rauch U, Fassler R, Garner CC, Gundelfinger ED (1995) Brevican, a chondroitin sulfate proteoglycan of rat brain, occurs as secreted and cell surface glycosylphosphatidylinositol-anchored isoforms. J Biol Chem 270(45):27206-27212.

found 10 datasets

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