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 Neurochemistry & Molecular Biology

 Membrane trafficking and cytoskeleton (AG Kessels)

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Leibniz Institute for Neurobiology
Brenneckestraße 6
39118 Magdeburg
Germany
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Endocytosis is critical for life. Vesicle formation during endo­cytosis involves complex structural and regulatory machinery. Our under­standing of this endocytic machinery has grown rapidly during the last decade, but surprisingly little is known about how it interconnects functionally with the cortical actin cytoskeleton underlying the plasma membrane and which cell biological and developmental processes critically rely on such an interplay.

In neurons, the interplay of cytomatrix and cytoskeletal components with membrane trafficking may be of high importance both pre- and postsynaptically. We have identified several molecular players at the functional interface between membrane trafficking and the actin cytoskeleton, such as syndapins, Abp1 and N-WASP.

Projects:


Selected Publications:

Kessels, M. M. & Qualmann, B. (2006). Syndapin oligomers interconnect the machineries for endocytic vesicle formation and the actin cytoskeleton.
J. Biol. Chem., 281, 13285-13299.

Kessels, M. M.*, Dong, J.*, Leibig, W., Westermann, P. & Qualmann, B. (2006). Complexes of syndapin II with dynamin II promote vesicle formation at the trans-Golgi network.
J. Cell Sci.., 119, 1504-1516.

Braun, A.*, Pinyol, R.*, Koch, D., Dahlhaus, R., Fonarev, P., Grant, B. D., Kessels, M. M. & Qualmann, B. (2005). EHD proteins associate with syndapin I and II and such interactions play a crucial role in endosomal recycling.
Mol. Biol. Cell , 16, 3642-3658.

Kessels, M. M. & Qualmann, B (2005). Extending the court for cortactin: from the cortex to the Golgi.
Nat. Cell Biol., 7, 448-449

tom Dieck, S.*, Altrock, W. D.*, Kessels, M. M., Qualmann, B., Regus, H., Brauner, D, Fejtová, A., Bracko, O., Gundelfinger, E. D. & Brandstätter, J. H. (2005). Molecular dissection of the photoreceptor ribbon synapse: physical interaction of Bassoon and RIBEYE is essential for the assembly of a functional ribbon complex.
J. Cell Biol., 168, 825-836.

Merrifield, C. J., Qualmann, B., Kessels, M. M. & Almers, W. (2004). Neuronal Wiskott Aldrich Syndrome Protein (N-WASP) and the Arp2/3 complex are recruited to sites of clathrin-mediated endocytosis in cultured fibroblasts.
Eur. J. Cell Biol., 83, 13-18.

Qualmann, B., Boeckers T. B., Jeromin, M., Gundelfinger, E. D. & Kessels, M. M. (2004). Linkage of the actin cytoskeleton to the postsynaptic density via interactions of Abp1 with ProSAP/Shanks.
J. Neurosci., 24, 2481-95.

Da Costa, S. R., Sou, E., Xie, J., Yarber, F. A., Okamoto, C. T., Pidgeon, M., Kessels, M. M., Mircheff, A. K., Schechter, J. E., Qualmann, B. & Hamm-Alvarez, S. F. (2003). Impairing actin filament or syndapin functions promotes accumulation of clathrin-coated vesicles at the apical plasma membrane of acinar epithelial cells.
Mol. Biol. Cell 14, 4397-4413.

Fenster, S. D. *, Kessels, M. M. *, Qualmann, B. *, Wook, J. C., Nash, J., Gundelfinger, E. D. & Garner, C. C. (2003). Interactions between piccolo and the actin/dynamin-binding protein Abp1 link vesicle endocytosis to presynaptic active zones.
J. Biol. Chem. 278, 20266-20277.

Gundelfinger, E. D.#, Kessels, M. M. #, & Qualmann, B.# (2003). Temporal and spatial coordination of exo- and endocytosis.
Nat. Rev. Mol. Cell Bio. 4, 127-139.

Fucini, R. V., Chen, J.-L., Sharma C., Kessels, M. M. & Stamnes, M. (2002). Golgi vesicle proteins are linked to the assembly of an actin complex defined by mAbp1.
Mol. Biol. Cell, 13, 621-631.

Kessels, M. M. & Qualmann, B. (2002). Syndapins integrate N-WASP in receptor-mediated endocytosis.
EMBO J., 21, 6083-6094.

Qualmann, B. & Kessels, M. M. (2002). Endocytosis and the cytoskeleton.
Int. Rev. Cytol., 220, 93-144.

Kessels, M. M., Engqvist-Goldstein, Å. E. Y., Drubin, D. G. & Qualmann, B. (2001). Mammalian Abp1, a signal-responsive F-actin-binding protein, links the actin cytoskeleton to endocytosis via the GTPase dynamin.
J. Cell Biol., 153, 351-366.

Kessels, M. M., Engqvist-Goldstein, Å. E. Y. & Drubin, D. G. (2000). Association of mouse actin-binding protein 1 (mAbp1/SH3P7), an src kinase target, with dynamic regions of the cortical actin cytoskeleton in response to Rac1 activation.
Mol. Biol. Cell, 11, 393-412.

Qualmann, B., Kessels, M. M. & Kelly, R. B. (2000). Molecular links between endocytosis and the actin cytoskeleton.
J. Cell Biol., 150, F111-116.

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