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 Molecular mechanism of plasticity (AG Kreutz)

 A maternal blood-borne survival factor for the developing and injured brain

Y-P30: A maternal blood-borne survival factor for the developing and injured brain.

Recently we describe the identification of a polypeptide survival-promoting factor produced by maternal and early postnatal peripheral blood mononuclear cells (PBMCs) of the immune system. The factor, termed Y-P30, most likely arises from proteolytical processing of a larger precursor protein and accumulates mainly in pyramidal neurons of the developing cortex and hippocampus but not in astrocytes. It is released from neurons grown in culture and substantially promotes the survival of cells in explant mono-cultures from the perinatal thalamus of the offspring. Y-P30 mRNA is not detectable in the infant or adult brain and is only present in blood cells of pregnant rats and humans but not in non-pregnant controls. Importantly, however, Y-P30 transcription can be induced in PBMCs of adult animals by a CNS lesion (i.e. optic nerve crush) pointing to a potential role of the factor not only in neuronal development but also in neuroinflammation after white matter injury.

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