LIN: Forschungsabteilungen > Akkustik, Lernen, Sprache > Unterpunkt Ebene 3 > Unterpunkt Ebene 4
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Value representation in sensory cortical areas during decision making: network mechanisms and neuromodulation
We investigate neuronal network mechanisms during uncertain decisions by in vivo multichannel recordings. We focus on the local circuit processing underlying dynamic oscillations. Pharmacological manipulations help us to characterize contributions of different transmitter systems. Computational models and human data of our collaborator (PD Dr. Gehrard Jocham) will help us to link our findings to general functional mechamisms of flexible and adaptive value coding in the brain.
Funding: CRC779 – 2016-2020; Marina Zempeltzi, Erika Kaschinski, Sara Bertazzoni; Collaboration: PD Dr. Gerhard Jocham, Dr. Matthias Deliano
in vivo multichannel recordings in rodent auditorx cortex during cognitively complex learning and optogenetic manipulation
In collaboration with the AG Neuro-Optics (Dr. Michael Lippert) we investigate plastic reorganizations in auditory cortex of behaving rodents during learning by chronically implanted multichannel electrodes. Using optogenetic tools we manipulate particularly dopaminergic neurotransmission in order to specify its impact during these processes. Funding: LPN/PAKT der WGL – 2015-2017; Network coordinator: Prof. Frank Ohl; Project staff: Michael Brunk; Collaboration: Dr. Michael Lippert
Impact of the cortical extracellular matrix on Einfluss der kortikalen Extrazellulärmatrix on cognitive learning processes in rodents
Based on our current knowledge that the extracellular matrix (ECM) impacts on cognitive learning (Happel et al., 2014b), we investigate together with the AG ECM (Dr. Renato Frischknecht) in different rodent species (Mongolian gerbils, mice; wild type and knockout-models) intrinsic and dynamic changes of the ECM during behavior with molecular and immunohistochemical methods. We use local enzymatic weakening of the ECM to promote neuroplasticity, flexibility of long-term memory reconsolidation in animals and potential translational developments for restorative plasticity (Happel et al., 2014b, Happel und Frischknecht, 2016).
Funding: WGL/LIN Special project – 2012-2016; Hartmut Niekisch, Julia Steinhardt, Mohammad El-Tabbal, Collaboration: Dr. Renato Frischknecht
Reorganization of cortical circuits after noise trauma as cause of central tinnitus
In collaboration with Prof. Ohl (LIN/SPL) and Prof. Holger Schulze (UK Erlangen-Nürnberg) we investigate short- and long-lasting of cortical circuits after noise trauma as a cause for the emergence and persistence of central tinnitus.
Funding: CRC TRR 31 – 2013-2017; Prinicipal investigator: Prof. Frank Ohl; Collaboration: Prof. Holger Schulze (UK Erlangen), Dr. Marcus Jeschke (Univ. Goettingen)
Laser-induced lesion of corticothalamic circuits and consequences for processing of complex auditory stimuli
Together with Dr. Eike Budinger (LIN/SPL) and Prof. Andrew King (University Oxford) we have established a laser-induced apoptosis of corticothalamic projections, to investigate the impact of temporal recurrent interactions between auditory thalamus and cortex for processing and perception of complex auditory stimuli in Mongolian gerbils and ferrets.
Funding: DAAD 2012 und Wellcome Principal Research Fellowship (to Prof. King) 2013-2016; Collaboration: Natsumi Homma, Prof. Victoria Bajo, Dr. Fernando Nodal (Oxford) Prof. Frank W. Ohl, Dr. Eike Budinger (LIN)