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Head:Dr. Wolfgang Tischmeyer
Special Lab Molecular Biological Techniques
Leibniz Institute for Neurobiology
Long-term plastic changes in the brain, including those supporting memory formation, are thought to depend on the sequential induction of regulatory and subsequently late structural target proteins that contribute to permanent functional alterations in neuronal cells and, in particular, their synaptic contacts. The aim of our research is the identification and functional characterisation of protein components and regulatory mechanisms that are responsible for the molecular and cellular basis of synaptic plasticity. Utilising proteome analysis, antisense intervention, and behavioural pharmacology, the work of the Special Lab has addressed the significance of defined gene products and their posttranslational modification for activity-dependent synaptic plasticity in a number of paradigms, such as an animal model of temporal lobe epilepsy, long-term potentiation and depression, and learning and memory formation.