Person Details
- Dr. Christina Spilker
- Leibniz Institute for Neurobiology
- Brenneckestr. 6
- 39118 Magdeburg
- Germany
- Telefon :
- +49 391 6263 92121
- E-Mail :
- Christina.Spilker@lin-magdeburg.de
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Forschungsinteressen
Test Forschungsinteressen
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Lebenslauf
- studied Biology (diploma) at the University of Bielefeld
- PhD in Neuroscience at the Leibniz Institute for Neurobiology, Magdeburg, Department Neurochemistry and Molecular Biology (Prof. Eckart Gundelfinger)
- in 2001/2002 Postdoc at the Neuroscience Research Center of the Charite, Signal Transduction Research Group (Dr. K.-H. Braunewell), Humboldt-University, Berlin
- 2002 – 2004 Postdoc at the Leibniz-Institute for Neurobiology, Magdeburg, Department Neurochemistry / Molecular Biology (Prof. Dr. E.D. Gundelfinger) and the Institute for Anatomy, Westfälische Wilhelms-Universität Münster, Research Group ‘Molecular Neurobiology’ (PD Dr. Tobias M. Böckers)
from 2005 senior scientist in the research group Neuroplasticity (Dr. Michael R. Kreutz)
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Publikationen
Schmeisser M, Ey E, Wegener S, Bockmann J, Stempel A, Kuebler A, Janssen A, Udvardi P, Shiban E, Spilker C, Balschun D, Skryabin B, Dieck S, Montag D, Leblond C, Faure P, Torquet N, Le Sourd A, Toro R, Grabrucker A, Shoichet S, Schmitz D, Kreutz M, Bourgeron T, Gundelfinger E, Boeckers T 2012 Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2 Nature 486 7402 256-260https://doi.org/10.1038/nature11015
Reddy P, Raghuram V, Hradsky J, Spilker C, Chakraborty A, Sharma Y, Mikhaylova M, Kreutz M 2014 Molecular dynamics of the neuronal EF-hand Ca<sup>2+</sup>-sensor Caldendrin PLoS ONE 9 7https://doi.org/10.1371/journal.pone.0103186
Spilker C, Kreutz M 2010 RapGAPs in brain European Journal of Neuroscience 32 1 1-9https://doi.org/10.1111/j.1460-9568.2010.07273.x
Dieterich D, Mikhaylova M, Zdobnova I, König I, Landwehr M, Kreutz M, Richter K, Landgraf P, Reissner C, Boeckers T, Spilker C, Garner C, Gundelfinger E, Kreutz M 2008 Caldendrin-Jacob PLoS Biology 6 2 286-306https://doi.org/10.1371/journal.pbio.0060034
Spilker C, Acuña Sanhueza G, Boeckers T, Kreutz M, Gundelfinger E 2008 SPAR2, a novel SPAR-related protein with GAP activity for Rap1 and Rap2 Journal of Neurochemistry 104 1 187-201https://doi.org/10.1111/j.1471-4159.2007.04991.x
Sandoval M, Sandoval R, Thomas U, Spilker C, Falcon R, Marengo J, Calderón R, Saavedra V, Heumann R, Bronfman F, Garner C, Gundelfinger E, Wyneken U 2007 Antagonistic effects of TrkB and p75<sup>NTR</sup> on NMDA receptor currents in post-synaptic densities transplanted into Xenopus oocytes Journal of Neurochemistry 101 6 1672-1684https://doi.org/10.1111/j.1471-4159.2007.04519.x
Blazejczyk M, Wojda U, Sobczak A, Spilker C, Bernstein H, Gundelfinger E, Kreutz M, Kuznicki J 2006 Ca<sup>2+</sup>-independent binding and cellular expression profiles question a significant role of calmyrin in transduction of Ca <sup>2+</sup>-signals to Alzheimer's disease-related presenilin 2 in forebrain Biochimica et Biophysica Acta - Molecular Basis of Disease 1762 1 66-72https://doi.org/10.1016/j.bbadis.2005.09.006
Boeckers T, Liedtke T, Spilker C, Dresbach T, Bockmann J, Kreutz M, Gundelfinger E 2005 C-terminal synaptic targeting elements for postsynaptic density proteins ProSAP1/Shank2 and ProSAP2/Shank3 Journal of Neurochemistry 92 3 519-524https://doi.org/10.1111/j.1471-4159.2004.02910.x
Mikhaylova M, Bera S, Bär J, Reddy P, Rankovic V, Spilker C, Bethge P, Sahin J, Kaushik R, Kähne T, Naumann M, Gundelfinger E, Kreutz M 2013 Encoding and transducing the synaptic or extrasynaptic origin of NMDA receptor signals to the nucleus Cell 152 5 1119-1133https://doi.org/10.1016/j.cell.2013.02.002
Wendholt D, Spilker C, Schmitt A, Dolnik A, Proepper C, Bockmann J, Sobue K, Gundelfinger E, Kreutz M, Boeckers T 2006 ProSAP-interacting protein 1 (ProSAPiP1), a novel protein of the postsynaptic density that links the spine-associated Rap-Gap (SPAR) to the scaffolding protein ProSAP2/Shank3 Journal of Biological Chemistry 281 19 13805-13816https://doi.org/10.1074/jbc.M601101200
Spilker C, Braunewell K 2003 Calcium-myristoyl switch, subcellular localization, and calcium-dependent translocation of the neuronal calcium sensor protein VILIP-3, and comparison with VILIP-1 in hippocampal neurons Molecular and Cellular Neurosciences 3 766-778http://www.scopus.com/inward/record.url?scp=0344737608&partnerID=8YFLogxK
Dresbach T, Hempelmann A, Spilker C, Dieck S, Garner C, Gundelfinger E 2003 Functional regions of the presynaptic cytomatrix protein Bassoon Molecular and Cellular Neurosciences 23 2 279-291https://doi.org/10.1016/S1044-7431(03)00015-0
Spilker C, Gundelfinger E, Braunewell K 2002 Evidence for different functional properties of the neuronal calcium sensor proteins VILIP-1 and VILIP-3 Biochimica et Biophysica Acta - Proteins and Proteomics 1600 1-2 118-127https://doi.org/10.1016/S1570-9639(02)00452-1
Braunewell K, Spilker C, Gundelfinger E 2002 Hippocampal expression of the calcium sensor protein visinin-like protein-1 in schizophrenia NeuroReport 13 4 393-396https://doi.org/10.1097/00001756-200203250-00006
Braunewell K, Brackmann M, Spilker C, Gundelfinger E 2001 Intracellular neuronal calcium sensor (NCS) protein VILIP-1 modulates cGMP signalling pathways in transfected neural cells and cerebellar granule neurones Journal of Neurochemistry 78 6 1277-1286https://doi.org/10.1046/j.1471-4159.2001.00506.x
Braunewell K, Spilker C, Gundelfinger E 2001 Abnormal localization of two neuronal calcium sensor proteins, visinin-like proteins (VILIPs)-1 and -3, in neocortical brain areas of Alzheimer disease patients Dementia and Geriatric Cognitive Disorders 12 2 110-116https://doi.org/10.1159/000051244
Bernstein H, Becker A, Keilhoff G, Spilker C, Gorczyca W, Braunewell K, Grecksch G 2003 Brain region-specific changes in the expression of calcium sensor proteins after repeated applications of ketamine to rats Neuroscience Letters 339 2 95-98https://doi.org/10.1016/S0304-3940(02)01482-9
Spilker C, Gundelfinger E, Braunewell K 1997 Calcium- and myristoyl-dependent subcellular localization of the neuronal calcium-binding protein VILIP in transfected PC12 cells Neuroscience Letters 225 2 126-128https://doi.org/10.1016/S0304-3940(97)00201-2
Spilker C, Richter K, Manahan-Vaughan D, Gundelfinger E, Braunewell K 2000 The neuronal EF-hand calcium-binding protein visinin-like protein-3 is expressed in cerebellar Purkinje cells and shows a calcium-dependent membrane association Neuroscience 96 1 121-129https://doi.org/10.1016/S0306-4522(99)00536-9
Spilker C, Nullmeier S, Grochowska K, Schumacher A, Butnaru I, Macharadze T, Gomes G, Yuanxiang P, Bayraktar G, Rodenstein C, Geiseler C, Kolodziej A, Lopez-Rojas J, Montag D, Angenstein F, Bär J, D’Hanis W, Roskoden T, Mikhaylova M, Budinger E, Ohl F, Stork O, Zenclussen A, Schwegler H, Kreutz M 2016 A Jacob/Nsmf Gene Knockout Results in Hippocampal Dysplasia and Impaired BDNF Signaling in Dendritogenesis PLoS Genetics 12 3https://doi.org/10.1371/journal.pgen.1005907
Spilker C, Grochowska K, Kreutz M 2016 What do we learn from the murine Jacob/Nsmf gene knockout for human disease? Rare Diseases 4 1 e1241361https://doi.org/10.1080/21675511.2016.1241361
Mikhaylova M, Bär J, van Bommel B, Schätzle P, Yuanxiang P, Hradsky J, Konietzny A, Loktionov E, Reddy P, Lopez-Rojas J, Spilker C, Kobler O, Raza S, Stork O, Hoogenraad C, Kreutz M 2018 Caldendrin Directly Couples Postsynaptic Calcium Signals to Actin Remodeling in Dendritic Spines Neuron 97 5 1110-1125.e14https://doi.org/10.1016/j.neuron.2018.01.046