Forschungsgruppe Neuroplastizität

Schwerpunktthemen unserer Forschergruppe sind zelluläre und molekulare Mechanismen neuronaler Plastizität im gesunden Gehirn, aber auch Störungen synaptischer Funktionen bei neuropsychiatrischen und neurodegenerativen Erkrankungen – so genannte Synaptopathien. Wir untersuchen die molekulare Dynamik von Postsynapsen, die Entschlüsselung von neuronalen Calcium-Signalen durch Calcium-Sensor-Proteine, die Kommunikation von Synapsen mit dem Zellkern und wie die synaptische Kontrolle von Genexpression auf die plastischen Eigenschaften von Synapsen zurückwirkt.

 

 

  • Leiter

    Leiter

    Michael R. Kreutz studierte Psychologie, Philosophie und Linguistik an der Universität Münster und promovierte anschließend in Verhaltens-Neurowissenschaften an der Ruhr-Universität Bochum. Anschließend wurde er wissenschaftlicher Mitarbeiter am Department of Brain and Cognitive Sciences am MIT, USA. Von 1990 bis 1993 war er wissenschaftlicher Mitarbeiter in der Abteilung Molekulare Neuroendokrinologie am Max-Planck-Institut für experimentelle Medizin in Göttingen.

    1993 zog er nach Magdeburg und leitet derzeit die Neuroplasticity Research Group (NPlast) am LIN.

    Seit Oktober 2015 hat er eine zweite Zugehörigkeit am Zentrum für Molekulare Neurobiologie (ZMNH) in Hamburg, wo er die Leibniz-Gruppe "Dendritische Organellen und synaptische Funktion" leitet.

     

  • Mitglieder

    Mitglieder

    Leiter  
    Dr. Michael Kreutz+49-391-6263-94181michael.kreutz(at)lin-magdeburg.de
    Wissenschaftliche Mitarbeiter  
    Dr. Mohamed Raafet Ammar+49-391-6263-94351mohamed.ammar(at)lin-magdeburg.de
    Dr. Anja M. Oelschlegel+49-391-6263-94371aoelschl(at)lin-magdeburg.de
    Dr. Anna Karpova+49-391-6263-94371anna.karpova(at)lin-magdeburg.de
    Dr. Guilherme Monteiro Gomes+49-391-6263-94361guilherme.gomes(at)lin-magdeburg.de
    Dr. Rajeev Raman+49-391-6263-94351rajeev.raman(at)lin-magdeburg.de
    Dr. PingAn YuanXiang+49-391-6263-94331yuanxiang.pingan(at)lin-magdeburg.de
    Dr. Irene Reyes Resina+49 391 6263 94361Irene.ReyesResina(at)lin-magdeburg.de
    Dr. Katarzyna Grochowska  
    Dr. Maria Andres-Alonso  
    Doktoranden  
    Eleonora Cuboni+49-391-6263-94211eleonora.cuboni(at)lin-magdeburg.de
    Sebastian Samer+49-391-6263-94331sebastian.samer(at)lin-magdeburg.de
    Stefano Patriarca+49-391-6263-94351 
    Helene Arndt+49-391-6263-94211 
    Judith Wolf+49-391-6263-94331judith.wolf(at)lin-magdeburg.de
    Maximilian Borgmeyer  
    Marit Sperveslage  
    Daniel Giffney+49-391-6263-94361 
    Technische Mitarbeiterinnen  
    Corinna Borutzki+49-391-6263-94211corinna.borutzki(at)lin-magdeburg.de
    Isabel Herbert+49-391-6263-94171Isabel.Herbert(at)lin-magdeburg.de
    Monika Marunde+49-391-6263-94211monika.marunde(at)lin-magdeburg.de
    Gäste  
    Dr. Julia Bär  
    Prof. Dr. Thomas Behnisch  
    Dr. Marina Mikhaylova  
  • Projekte

    Projekte

    Im Zentrum der Arbeit unserer Forschergruppe steht die Frage, wie langfristige Veränderungen in der Struktur von Synapsen zu deren Rolle bei der Gedächtnisbildung beitragen. Eine Schlüsselrolle scheint hierbei die Kommunikation mit dem Zellkern zu spielen. 

    Wir untersuchen Mechanismen des Proteintransports aus Synapsen zum Zellkern, die Regulation von Genexpression und deren Bedeutung für die Stabilität und Funktion von Synapsen. Hier haben wir in den vergangenen Jahren wesentliche Fortschritte gemacht, auch wenn noch viele Fragen offenbleiben. Von großem Interesse für uns ist in diesem Zusammenhang vor allem, welche Relevanz die untersuchten Signalwege für die Alzheimer-Demenz haben.
     

    ProCognito - Pflanzliche Wirkstoffe zum Erhalt der kognitiven Leistungsfähigkeit im Alter

    Pflanzliche Wirkstoffe besitzen aufgrund ihrer evolutionären Entwicklung als Verteidigungssubstanzen ein besonderes Potential für neurologische Anwendungen und werden vom Menschen seit Jahr­tausenden genutzt. Als sessile Organismen verfügen Pflanzen weiterhin über viele antioxidative und antiinflammatorische Substanzen zur Stressbewältigung mit erwiesener positiver Wirkung am Menschen. In der Bevölkerung ist zudem eine hohe Akzeptanz zur Verwendung von natürlichen Produkten vorhanden. Im beantragten Projekt sollen daher die Kompetenzen der Verbundpartner PhytoAD und Metabolisches Syndrom aus der ersten Förderphase gekoppelt werden, um Wirkung und Anwendungspotential von ausgewählten Pflanzenextrakten und -stoffen spezifisch im Hinblick auf synaptische Prozesse zu untersuchen. Gleichzeitig stellt das IPB seine digitalisierte Substanzbibliothek, die derzeit die umfassendste Substanzsammlung mit natürlichen Wirkstoffen innerhalb Sachsen-Anhalts darstellt, im Rahmen des Forschungsverbundes 'Autonomie im Alter' für dieses Projekt, aber auch für weitere spezifische Fragestellungen und Anwendungen im Verbund zur Verfügung. Im Projekt gewonnene Daten werden in diese Datenbank eingepflegt und sind somit auch für zukünftige Anwendungen abrufbar. Um einen engen elektronischen Datenaustausch innerhalb des Verbundes zu ermöglichen, wird die unter Führung des IPB entwickelte Leibniz-Wirkstoff-Cloud (Leibniz-E-Center Bioactives) für den Forschungsverbund AiA geöffnet. Das Leibniz-E-Center Bioactives stellt die gemeinsam nutzbare Infrastruktur für die Suche, Analyse, Austausch sowie Management von Information und big data im Bereich Wirkstoffe und biologische Aktivität dar. Aufbau und Anwendung dieser Plattform soll von dem KMU Ontochem IT Solutions unterstützt werden, das patentierte Verfahren zur Implementierung von Ontologien, automatisiertem Text-Mining und Machine Learning zu medizinisch-pharmakologischen und Food-Anwendungen einbringt. Diese innovative elektronische Informations- und Kommunikationstechnologie-Anwendung soll auch über den Förderzeitraum hinaus einen nachhaltigen Mehrwert in der interdisziplinären Forschungskommunikation generieren.

     

    Weitere Informationen zu unseren Projekten finden Sie hier: http://www.kreutzlab.com/

  • Laufende Drittmittelprojekte

    Laufende Drittmittelprojekte

    2017-2019
    EU-JPND STAD

    2016-2019
    DFG SFB 779 TP B8
    www.sfb779.de

    2019-2021
    DFG FOR 2419: Plasticity versus Stability - Molecular Mechanisms of Synaptic Strength

    2019-2023
    DFG RTG 2413 'SynAge'
    gp.cbbs.eu/synage-rtg-2413/

    2015-2019
    DFG Kr1879 6-1

    2015-2020
    BMBF ENERGI 01GQ1421

    2018-2020
    LSA Exzellenzinitiave AiA Metabolisches Syndrom
    autonomie-im-alter.ovgu.de/Projekte/Verbundprojekte.html

    2019-2022
    LSA Exzellenzinitiave AiA ProCognito

    2017-2020
    Leibniz SAW Synaptoneurolipidomics

    2017-2020
    Leibniz SAW Neurotranslation

    2019-2022
    Leibniz SAW SyMetAge

  • Publikationen

    Publikationen

    Ausgewählte Publikationen

    Andres-Alonso M, Ammar MR, Butnaru I, Gomes GM, Acuña Sanhueza G, Raman R, Yuanxiang P, Borgmeyer M, Lopez-Rojas J, Raza SA, Brice N, Hausrat TJ, Macharadze T, Diaz-Gonzalez S, Carlton M, Failla AV, Stork O, Schweizer M, Gundelfinger ED, Kneussel M, Spilker C, Karpova A, Kreutz MR. 2019. SIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminals. Nature Communications. 10(1):Article 5448. https://doi.org/10.1038/s41467-019-13224-z

    Bayraktar G, Yuanxiang P, Confettura AD, Gomes GM, Raza SA, Stork O, Tajima S, Suetake I, Karpova A, Yildirim F, Kreutz MR. 2020. Synaptic control of DNA methylation involves activity-dependent degradation of DNMT3A1 in the nucleus. Neuropsychopharmacology 0:1–11. https://doi.org/10.1038/s41386-020-0780-2             

    Koopmans F, van Nierop P, Andres-Alonso M, Byrnes A, Cijsouw T, Coba MP, Cornelisse LN, Farrell RJ, Goldschmidt HL, Howrigan DP, Hussain NK, Imig C, de Jong APH, Jung H, Kohansalnodehi M, Kramarz B, Lipstein N, Lovering RC, MacGillavry H, Mariano V, Mi H, Ninov M, Osumi-Sutherland D, Pielot R, Smalla K-H, Tang H, Tashman K, Toonen RFG, Verpelli C, Reig-Viader R, Watanabe K, van Weering J, Achsel T, Ashrafi G, Asi N, Brown TC, De Camilli P, Feuermann M, Foulger RE, Gaudet P, Joglekar A, Kanellopoulos A, Malenka R, Nicoll RA, Pulido C, de Juan-Sanz J, Sheng M, Südhof TC, Tilgner HU, Bagni C, Bayés À, Biederer T, Brose N, Chua JJE, Dieterich DC, Gundelfinger ED, Hoogenraad C, Huganir RL, Jahn R, Kaeser PS, Kim E, Kreutz MR, McPherson PS, Neale BM, O'Connor V, Posthuma D, Ryan TA, Sala C, Feng G, Hyman SE, Thomas PD, Smit AB, Verhage M. 2019. SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse. Neuron. 103(2):217-234.e4. https://doi.org/10.1016/j.neuron.2019.05.002

    Mikhaylova M, Bär J, van Bommel B, Schätzle P, YuanXiang PA, Raman R, Hradsky J, Konietzny A, Loktionov EY, Reddy PP, Lopez-Rojas J, Spilker C,Kobler O, Raza SA, Stork O, Hoogenraad CC, Kreutz MR. 2018. Caldendrin Directly Couples Postsynaptic Calcium Signals to Actin Remodeling in Dendritic Spines. Neuron. 97(5):1110-1125.e14. https://doi.org/10.1016/j.neuron.2018.01.046

    Grochowska KM, Yuanxiang P, Bär J, Raman R, Brugal G, Sahu G, Schweizer M, Bikbaev A, Schilling S, Demuth HU, Kreutz MR. 2017. Posttranslational modification impact on the mechanism by which amyloid-β induces synaptic dysfunction. EMBO Reports. 18(6):962-981. https://doi.org/10.15252/embr.201643519

    Kravchick DO, Karpova A, Hrdinka M, Lopez-Rojas J, Iacobas S, Carbonell AU, Iacobas DA, Kreutz MR, Jordan BA. 2016. Synaptonuclear messenger PRR7 inhibits c-Jun ubiquitination and regulates NMDA-mediated excitotoxicity. EMBO Journal. 35(17):1923-1934. https://doi.org/10.15252/embj.201593070

    Dinamarca MC, Guzzetti F, Karpova A, Lim D, Mitro N, Musardo S, Mellone M, Marcello E, Stanic J, Samaddar T, Burguière A, Caldarelli A, Genazzani AA, Perroy J, Fagni L, Canonico PL, Kreutz MR, Gardoni F, Di Luca M. 2016. Ring finger protein 10 is a novel synaptonuclear messenger encoding activation of NMDA receptors in hippocampus. eLife. 5(MARCH2016). https://doi.org/10.7554/eLife.12430.001

    Spilker C, Nullmeier S, Grochowska KM, Schumacher A, Butnaru I, Macharadze T, Gomes GM, YuanXiang P, Bayraktar G, Rodenstein C, Geiseler C, Kolodziej A, Lopez-Rojas J, Montag D, Angenstein F, Bär J, D’Hanis W, Roskoden T, Mikhaylova M, Budinger E, Ohl FW, Stork O, Zenclussen AC, Karpova A, Schwegler H, Kreutz MR. 2016. A Jacob/Nsmf Gene Knockout Results in Hippocampal Dysplasia and Impaired BDNF Signaling in Dendritogenesis. PLoS Genetics. 12(3). https://doi.org/10.1371/journal.pgen.1005907

    Mikhaylova M, Bera S, Kobler O, Frischknecht R, Kreutz MR. 2016. A Dendritic Golgi Satellite between ERGIC and Retromer. Cell Reports. 14(2):189-199. https://doi.org/10.1016/j.celrep.2015.12.024

    Panayotis N, Karpova A, Kreutz MR, Fainzilber M. 2015. Macromolecular transport in synapse to nucleus communication. Trends in Neurosciences. 38(2):108-116. https://doi.org/10.1016/j.tins.2014.12.001

    Karpova A, Mikhaylova M, Bera S, Bär J, Reddy PP, Behnisch T, Rankovic V, Spilker C, Bethge P, Sahin J, Kaushik R, Zuschratter W, Kähne T, Naumann M, Gundelfinger ED, Kreutz MR. 2013. Encoding and transducing the synaptic or extrasynaptic origin of NMDA receptor signals to the nucleus. Cell. 152(5):1119-1133. https://doi.org/10.1016/j.cell.2013.02.002

     

    Alle Publikationen der Gruppe

    2020

    Alkozi HA, Navarro G, Aguinaga D, Reyes-Resina I, Sanchez-Naves J, Pérez de Lara MJ, Franco R, Pintor J. 2020. Adreno–melatonin receptor complexes control ion homeostasis and intraocular pressure - their disruption contributes to hypertensive glaucoma. British Journal of Pharmacology. 177(9):2090-2105. https://doi.org/10.1111/bph.14971

    Bayraktar G, Yuanxiang P, Confettura AD, Gomes GM, Raza SA, Stork O, Tajima S, Suetake I, Karpova A, Yildirim F, Kreutz MR. 2020. Synaptic control of DNA methylation involves activity-dependent degradation of DNMT3A1 in the nucleus. Neuropsychopharmacology 0:1–11. https://doi.org/10.1038/s41386-020-0780-2             

    Grochowska KM, Kaushik R, Gomes GM, Raman R, Bär J, Bayraktar G, Samer S, Reyes-Resina I, Spilker C, Morawski M, Rossner S, Brugal GN, Karpova A, Kreutz MR. 2020. A molecular mechanism by which amyloid-β induces transcriptional inactivation of CREB in Alzheimer’s Disease. bioRxiv. https://doi.org/10.1101/2020.01.08.898304

    Jain P, Materazzi S, De Logu F, Rossi Degl'Innocenti D, Fusi C, Li Puma S, Marone IM, Coppi E, Holzer P, Geppetti P, Nassini R. 2020. Transient receptor potential ankyrin 1 contributes to somatic pain hypersensitivity in experimental colitis. Scientific Reports. 10(1):Article 8632. https://doi.org/10.1038/s41598-020-65618-5

    Kopczynski D, Hentschel A, Coman C, Schebb NH, Hornemann T, Mashek DG, Hartung NM, Shevchuk O,  Schött HF, Lorenz K, Torta F, Burla B, Zahedi RP, Sickmann A, Kreutz MR, Ejsing CS, Medenbach J, Ahrends R. 2020. Simple targeted assays for metabolic pathways and signaling: a powerful tool for targeted proteomics. Anal Chem. https://doi.org/10.1021/acs.analchem.0c02793

    Reyes-Resina I, Awad Alkozi H, Del Ser-Badia A, Sánchez-Naves J, Lillo J, Jiménez J, Pintor J, Navarro G, Franco R. 2020. Expression of Melatonin and Dopamine D3 Receptor Heteromers in Eye Ciliary Body Epithelial Cells and Negative Correlation with Ocular Hypertension. Cells. 9(1):Article 152. https://doi.org/10.3390/cells9010152

     

    2019

    Andres-Alonso M, Ammar MR, Butnaru I, Gomes GM, Acuña Sanhueza G, Raman R, Yuanxiang P, Borgmeyer M, Lopez-Rojas J, Raza SA, Brice N, Hausrat TJ, Macharadze T, Diaz-Gonzalez S, Carlton M, Failla AV, Stork O, Schweizer M, Gundelfinger ED, Kneussel M, Spilker C, Karpova A, Kreutz MR. 2019. SIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminals. Nature Communications. 10(1):Article 5448. doi.org/10.1038/s41467-019-13224-z

    Dell'Orco D, Koch K-W, Kreutz MR, Naranjo JR, Schwaller B. 2019. Editorial: Neuronal Calcium Sensors in Health and Disease. Frontiers in Molecular Neuroscience. 12:Article 278. https://doi.org/10.3389/fnmol.2019.00278

    Kiran U, Kreutz MR, Sharma Y, Chakraborty A. 2019. Tryptophan Scanning Mutagenesis of EF-Hand Motifs. Heizmann C, editor. In Calcium-Binding Proteins of the EF-Hand Superfamily. Humana Press. pp. 567-581. (Methods in Molecular Biology). https://doi.org/10.1007/978-1-4939-9030-6_35

    Koopmans F, van Nierop P, Andres-Alonso M, Byrnes A, Cijsouw T, Coba MP, Cornelisse LN, Farrell RJ, Goldschmidt HL, Howrigan DP, Hussain NK, Imig C, de Jong APH, Jung H, Kohansalnodehi M, Kramarz B, Lipstein N, Lovering RC, MacGillavry H, Mariano V, Mi H, Ninov M, Osumi-Sutherland D, Pielot R, Smalla K-H, Tang H, Tashman K, Toonen RFG, Verpelli C, Reig-Viader R, Watanabe K, van Weering J, Achsel T, Ashrafi G, Asi N, Brown TC, De Camilli P, Feuermann M, Foulger RE, Gaudet P, Joglekar A, Kanellopoulos A, Malenka R, Nicoll RA, Pulido C, de Juan-Sanz J, Sheng M, Südhof TC, Tilgner HU, Bagni C, Bayés À, Biederer T, Brose N, Chua JJE, Dieterich DC, Gundelfinger ED, Hoogenraad C, Huganir RL, Jahn R, Kaeser PS, Kim E, Kreutz MR, McPherson PS, Neale BM, O'Connor V, Posthuma D, Ryan TA, Sala C, Feng G, Hyman SE, Thomas PD, Smit AB, Verhage M. 2019. SynGO: An Evidence-Based, Expert-Curated Knowledge Base for the Synapse. Neuron. 103(2):217-234.e4. https://doi.org/10.1016/j.neuron.2019.05.002

    Lombino FL, Muhia M, Lopez-Rojas J, Brill MS, Thies E, Ruschkies L, Lutz D, Richter M, Hausrat TJ, Lopes AT, McNally FJ, Hermans-Borgmeyer I, Dunleavy JEM, Hoffmeister-Ullerich S, Frotscher M, Misgeld T, Kreutz MR, de Anda FC, Kneussel M. 2019. The Microtubule Severing Protein Katanin Regulates Proliferation of Neuronal Progenitors in Embryonic and Adult Neurogenesis. Scientific Reports. 9(1):Article 15940. https://doi.org/10.1038/s41598-019-52367-3

    Meka DP, Scharrenberg R, Zhao B, Kobler O, König T, Schaefer I, Schwanke B, Klykov S, Richter M, Eggert D, Windhorst S, Dotti CG, Kreutz MR, Mikhaylova M, Calderon de Anda F. 2019. Radial somatic F-actin organization affects growth cone dynamics during early neuronal development. EMBO Reports. 20(12):Article e47743. https://doi.org/10.15252/embr.201947743

    Mundhenk J, Fusi C, Kreutz MR. 2019. Caldendrin and Calneurons-EF-Hand CaM-Like Calcium Sensors With Unique Features and Specialized Neuronal Functions. Frontiers in Molecular Neuroscience. 12:Article 16. https://doi.org/10.3389/fnmol.2019.00016

    Neumann JR, Dash-Wagh S, Jack A, Räk A, Jüngling K, Hamad MIK, Pape H-C, Kreutz MR, Puskarjov M, Wahle P. 2019. The primate-specific peptide Y-P30 regulates morphological maturation of neocortical dendritic spines. PLoS ONE. 14(2):Article e0211151. https://doi.org/10.1371/journal.pone.0211151

     

    2018

    Angelats E, Requesens M, Aguinaga D, Kreutz MR, Franco R, Navarro G. 2018. Neuronal calcium and cAMP cross-talk mediated by cannabinoid CB1 receptor and EF-hand calcium sensor interactions. Frontiers in Cell and Developmental Biology. 6(JUL):67. https://doi.org/10.3389/fcell.2018.00067

    Bayraktar G, Kreutz MR. 2018. Neuronal DNA Methyltransferases: Epigenetic Mediators between Synaptic Activity and Gene Expression?. Neuroscientist. 24(2):171-185. https://doi.org/10.1177/1073858417707457

    Bayraktar G, Kreutz MR. 2018. The Role of Activity-Dependent DNA Demethylation in the Adult Brain and in Neurological Disorders. Frontiers in Molecular Neuroscience. 11:169. https://doi.org/10.3389/fnmol.2018.00169

    Dumenieu M, Senkov O, Mironov A, Bourinet E, Kreutz MR, Dityatev A, Heine M, Bikbaev A, Lopez-Rojas J. 2018. The low-threshold calcium channel Cav3.2 mediates burst firing of mature dentate granule cells. Cerebral Cortex. 28(7):2594-2609. https://doi.org/10.1093/cercor/bhy084

    Franco R, Aguinaga D, Reyes I, Canela EI, Lillo J, Tarutani A, Hasegawa M, del Ser-Badia A, del Rio JA, Kreutz MR, Saura CA, Navarro G. 2018. N-Methyl-D-Aspartate Receptor Link to the MAP Kinase Pathway in Cortical and Hippocampal Neurons and Microglia Is Dependent on Calcium Sensors and Is Blocked by α-Synuclein, Tau, and Phospho-Tau in Non-transgenic and Transgenic APPSw,Ind Mice. Frontiers in Molecular Neuroscience. 11:273. https://doi.org/10.3389/fnmol.2018.00273

    Heise C, Preuss JM, Schroeder JC, Battaglia CR, Kolibius J, Schmid R, Kreutz MR, Kas MJH, Burbach JPH, Boeckers TM. 2018. Heterogeneity of cell surface glutamate and GABA receptor expression in shank and CNTN4 autism mouse models. Frontiers in Molecular Neuroscience. 11. https://doi.org/10.3389/fnmol.2018.00212

    Kaushik R, Morkovin E, Schneeberg J, Confettura AD, Kreutz MR, Senkov O, Dityatev A. 2018. Traditional Japanese Herbal Medicine Yokukansan Targets Distinct but Overlapping Mechanisms in Aged Mice and in the 5xFAD Mouse Model of Alzheimer's Disease. Frontiers in Aging Neuroscience. 10. https://doi.org/10.3389/fnagi.2018.00411

    Mikhaylova M, Bär J, van Bommel B, Schätzle P, YuanXiang PA, Raman R, Hradsky J, Konietzny A, Loktionov EY, Reddy PP, Lopez-Rojas J, Spilker C,Kobler O, Raza SA, Stork O, Hoogenraad CC, Kreutz MR. 2018. Caldendrin Directly Couples Postsynaptic Calcium Signals to Actin Remodeling in Dendritic Spines. Neuron. 97(5):1110-1125.e14. https://doi.org/10.1016/j.neuron.2018.01.046

    Mikhaylova M, Kreutz MR. 2018. Geclusterte Plastizität bei Langzeitpotenzierung: Wie starke Synapsen bestehen bleiben, um Langzeitgedächtnis aufrechtzuerhalten. Neuroforum. 24(3):195-201. doi.org/10.1515/nf-2018-0006, https://doi.org/10.1515/nf-2018-A006

    Yun D, Zhuang Y, Kreutz MR, Behnisch T. 2018. The role of 19S proteasome associated deubiquitinases in activity-dependent hippocampal synaptic plasticity. Neuropharmacology. 133:354-365. https://doi.org/10.1016/j.neuropharm.2018.01.043

     

    2017

    Duménieu M, Oulé M, Kreutz MR, Lopez-Rojas J. 2017. The segregated expression of voltage-gated potassium and sodium channels in neuronal membranes: Functional implications and regulatory mechanisms. Frontiers in Cellular Neuroscience. 11:115. https://doi.org/10.3389/fncel.2017.00115

    Grochowska KM, Yuanxiang P, Bär J, Raman R, Brugal G, Sahu G, Schweizer M, Bikbaev A, Schilling S, Demuth HU, Kreutz MR. 2017. Posttranslational modification impact on the mechanism by which amyloid-β induces synaptic dysfunction. EMBO Reports. 18(6):962-981. https://doi.org/10.15252/embr.201643519

    Homiack D, O'Cinneide E, Hajmurad S, Barrileaux B, Stanley M, Kreutz MR, Schrader LA. 2017. Predator odor evokes sex-independent stress responses in male and female Wistar rats and reduces phosphorylation of cyclic-adenosine monophosphate response element binding protein in the male, but not the female hippocampus. Hippocampus. 27(9):1016-1029. https://doi.org/10.1002/hipo.22749

    Katrukha EA, Mikhaylova M, van Brakel HX, Van Bergen En Henegouwen PMP, Akhmanova A, Hoogenraad CC, Kapitein LC. 2017. Probing cytoskeletal modulation of passive and active intracellular dynamics using nanobody-functionalized quantum dots. Nature Communications. 8. https://doi.org/10.1038/ncomms14772

    Kiran U, Regur P, Kreutz MR, Sharma Y, Chakraborty A. 2017. Intermotif Communication Induces Hierarchical Ca2+ Filling of Caldendrin. Biochemistry. 56(19):2467-2476. https://doi.org/10.1021/acs.biochem.7b00132

    Zhao B, Meka DP, Scharrenberg R, König T, Schwanke B, Kobler O, Windhorst S, Kreutz MR, Mikhaylova M, Calderon De Anda F. 2017. Microtubules Modulate F-actin Dynamics during Neuronal Polarization. Scientific Reports. 7(1). https://doi.org/10.1038/s41598-017-09832-8

     

    2016

    Bera S, Bayraktar G, Grochowska KM, da Rosa MM, Kreutz MR. 2016. Activity dependent protein transport from the synapse to the nucleus. In Dendrites: Development and Disease. Springer Japan. pp. 111-124. https://doi.org/10.1007/978-4-431-56050-0_5

    Bera S, Raghuram V, Mikhaylova M, Kreutz MR. 2016. A plasmid-based expression system to study protein-protein interactions at the Golgi in vivo. Analytical Biochemistry. 502:50-52. https://doi.org/10.1016/j.ab.2016.02.016

    Bikbaev A, Duménieu M, Lopez-Rojas J, Heine M. 2016. Localising receptors and channels across the dendritic arbour. In Dendrites: Development and Disease. Springer Japan. pp. 387-424. https://doi.org/10.1007/978-4-431-56050-0_16

    Dieterich DC, Kreutz MR. 2016. Proteomics of the synapse - A quantitative approach to neuronal plasticity. Molecular and Cellular Proteomics. 15(2):368-381. doi.org/10.1074/mcp.R115.051482

    Dinamarca MC, Guzzetti F, Karpova A, Lim D, Mitro N, Musardo S, Mellone M, Marcello E, Stanic J, Samaddar T, Burguière A, Caldarelli A, Genazzani AA, Perroy J, Fagni L, Canonico PL, Kreutz MR, Gardoni F, Di Luca M. 2016. Ring finger protein 10 is a novel synaptonuclear messenger encoding activation of NMDA receptors in hippocampus. eLife. 5(MARCH2016). https://doi.org/10.7554/eLife.12430.001

    Heise C, Schroeder JC, Schoen M, Halbedl S, Reim D, Woelfle S, Kreutz MR, Schmeisser MJ, Boeckers TM. 2016. Selective localization of shanks to VGLUT1-positive excitatory synapses in the mouse hippocampus. Frontiers in Cellular Neuroscience. 10(APR). https://doi.org/10.3389/fncel.2016.00106

    Hrdinka M, Sudan K, Just S, Drobek A, Stepanek O, Schlüter D, Reinhold D, Jordan BA, Gintschel P, Schraven B, Kreutz MR. 2016. Normal development and function of T cells in proline rich 7 (Prr7) deficient mice. PLoS ONE. 11(9). https://doi.org/10.1371/journal.pone.0162863

    Kevenaar JT, Bianchi S, Van Spronsen M, Olieric N, Lipka J, Frias CP, Mikhaylova M, Harterink M, Keijzer N, Wulf PS, Hilbert M, Kapitein LC, De Graaff E, Ahkmanova A, Steinmetz MO, Hoogenraad CC. 2016. Kinesin-Binding Protein Controls Microtubule Dynamics and Cargo Trafficking by Regulating Kinesin Motor Activity. Current Biology. 26(7):849-861. https://doi.org/10.1016/j.cub.2016.01.048

    Kravchick DO, Karpova A, Hrdinka M, Lopez-Rojas J, Iacobas S, Carbonell AU, Iacobas DA, Kreutz MR, Jordan BA. 2016. Synaptonuclear messenger PRR7 inhibits c-Jun ubiquitination and regulates NMDA-mediated excitotoxicity. EMBO Journal. 35(17):1923-1934. https://doi.org/10.15252/embj.201593070

    Lopez-Rojas J, Heine M, Kreutz MR. 2016. Plasticity of intrinsic excitability in mature granule cells of the dentate gyrus. Scientific Reports. 6. https://doi.org/10.1038/srep21615

    Lopez-Rojas J, Kreutz MR. 2016. Mature granule cells of the dentate gyrus-Passive bystanders or principal performers in hippocampal function?. Neuroscience and Biobehavioral Reviews. 64:167-174. https://doi.org/10.1016/j.neubiorev.2016.02.021

    Melgarejo da Rosa M, Yuanxiang PA, Brambilla R, Kreutz MR, Karpova A. 2016. Synaptic GluN2B/CaMKII-α signaling induces synapto-nuclear transport of ERK and jacob. Frontiers in Molecular Neuroscience. 9(AUG). https://doi.org/10.3389/fnmol.2016.00066

    Mikhaylova M, Bera S, Kobler O, Frischknecht R, Kreutz MR. 2016. A Dendritic Golgi Satellite between ERGIC and Retromer. Cell Reports. 14(2):189-199. https://doi.org/10.1016/j.celrep.2015.12.024

    Spilker C, Grochowska KM, Kreutz MR. 2016. What do we learn from the murine Jacob/Nsmf gene knockout for human disease?. Rare Diseases. 4(1):e1241361. https://doi.org/10.1080/21675511.2016.1241361

    Spilker C*, Nullmeier S*, Grochowska KM*, Schumacher A, Butnaru I, Macharadze T, Gomes GM, YuanXiang P, Bayraktar G, Rodenstein C, Geiseler C, Kolodziej A, Lopez-Rojas J, Montag D, Angenstein F, Bär J, D’Hanis W, Roskoden T, Mikhaylova M, Budinger E, Ohl FW, Stork O, Zenclussen AC, Karpova A, Schwegler H, Kreutz MR. 2016. A Jacob/Nsmf Gene Knockout Results in Hippocampal Dysplasia and Impaired BDNF Signaling in Dendritogenesis. PLoS Genetics. 12(3). https://doi.org/10.1371/journal.pgen.1005907                       *equal contribution

    Yuan Xiang P, Janc O, Grochowska KM, Kreutz MR, Reymann KG. 2016. Dopamine agonists rescue Aβ-induced LTP impairment by Src-family tyrosine kinases. Neurobiology of Aging. 40:98-102. https://doi.org/10.1016/j.neurobiolaging.2016.01.008

     

    2015

    Bera S, Thillai K, Sriraman K, Jayaraman G. 2015. Process strategies for enhancing recombinant streptokinase production in Lactococcus lactis cultures using P170 expression system. Biochemical Engineering Journal. 93:94-101. https://doi.org/10.1016/j.bej.2014.07.009

    Hradsky J, Bernstein HG, Marunde M, Mikhaylova M, Kreutz MR. 2015. Alternative Splicing, Expression and Cellular Localization of Calneuron-1 in the Rat and Human Brain. Journal of Histochemistry and Cytochemistry. 63(10):793-804. https://doi.org/10.1369/0022155415595841

    Lever MB, Karpova A, Kreutz MR. 2015. An importin code in neuronal transport from synapse-to-nucleus?. Frontiers in Molecular Neuroscience. 8(JULY). https://doi.org/10.3389/fnmol.2015.00033

    Mikhaylova M, Cloin BMC, Finan K, Van Den Berg R, Teeuw J, Kijanka MM, Sokolowski M, Katrukha EA, Maidorn M, Opazo F, Moutel S, Vantard M, Perez F, Van Bergen En Henegouwen PMP, Hoogenraad CC, Ewers H, Kapitein LC. 2015. Resolving bundled microtubules using anti-tubulin nanobodies. Nature Communications. 6. https://doi.org/10.1038/ncomms8933

    Neumann JR, Dash-Wagh S, Jüngling K, Tsai T, Meschkat M, Räk A, Schönfelder S, Riedel C, Hamad MIK, Wiese S, Pape H-C, Gottmann K, Kreutz MR, Wahle P. 2015. Y-P30 promotes axonal growth by stabilizing growth cones. Brain Structure and Function. 220(4):1935-1950. https://doi.org/10.1007/s00429-014-0764-2

    Panayotis N, Karpova A, Kreutz MR, Fainzilber M. 2015. Macromolecular transport in synapse to nucleus communication. Trends in Neurosciences. 38(2):108-116. https://doi.org/10.1016/j.tins.2014.12.001

     

    2014

    Bera S, Kreutz MR. 2014. When synaptic proteins meet the genome: Transcriptional regulation in cell death and plasticity by the synapto-nuclear messenger jacob. Neuropsychopharmacology. 39(1):245-246. https://doi.org/10.1038/npp.2013.204

    Fan W, Fu T. 2014. Somatostatin modulates LTP in hippocampal CA1 pyramidal neurons: Differential activation conditions in apical and basal dendrites. Neuroscience Letters. 561:1-6. https://doi.org/10.1016/j.neulet.2013.12.025

    Gomes GM, Dalmolin GD, Bär J, Karpova A, Mello CF, Kreutz MR, Rubin MA. 2014. Inhibition of the polyamine system counteracts β-amyloid peptide-induced memory impairment in mice: Involvement of extrasynaptic NMDA receptors. PLoS ONE. 9(6). https://doi.org/10.1371/journal.pone.0099184

    Grabrucker S, Jannetti L, Eckert M, Gaub S, Chhabra R, Pfaender S, Mangus K, Reddy PP, Rankovic V, Schmeisser MJ, Kreutz MR, Ehret G, Boeckers TM, Grabrucker AM. 2014. Zinc deficiency dysregulates the synaptic ProSAP/Shank scaffold and might contribute to autism spectrum disorders. Brain. 137(1):137-152. https://doi.org/10.1093/brain/awt303

    Kaushik R, Grochowska KM, Butnaru I, Kreutz MR. 2014. Protein trafficking from synapse to nucleus in control of activity-dependent gene expression. Neuroscience. 280:340-350. https://doi.org/10.1016/j.neuroscience.2014.09.011

    Landgraf P, Mikhaylova M, Macharadze T, Borutzki C, Zenclussen AC, Wahle P, Kreutz MR. 2014. Binding of Y-P30 to syndecan 2/3 regulates the nuclear localization of CASK. PLoS ONE. 9(2). https://doi.org/10.1371/journal.pone.0085924

    Mikhaylova M, Karpova A, Bär J, Bethge P, YuanXiang P, Chen Y, Zuschratter W, Behnisch T, Kreutz MR. 2014. Cellular distribution of the NMDA-receptor activated synapto-nuclear messenger Jacob in the rat brain. Brain Structure and Function. 219(3):843-860. https://doi.org/10.1007/s00429-013-0539-1

    Mikhaylova M, Schumacher A, Borutzki C, Neumann JR, Macharadze T, El-Mousleh T, Wahle P, Zenclussen AC, Kreutz MR. 2014. Analysis of Y-P30/Dermcidin expression and properties of the Y-P30 peptide. BMC Research Notes. 7(1). https://doi.org/10.1186/1756-0500-7-400

    Navarro G, Aguinaga D, Moreno E, Hradsky J, Reddy PP, Cortés A, Mallol J, Casadó V, Mikhaylova M, Kreutz MR, Lluís C, Canela EI, McCormick PJ, Ferré S. 2014. Intracellular calcium levels determine differential modulation of allosteric interactions within G protein-coupled receptor heteromers. Chemistry and Biology. 21(11):1546-1556. https://doi.org/10.1016/j.chembiol.2014.10.004

    Reddy PP, Raghuram V, Hradsky J, Spilker C, Chakraborty A, Sharma Y, Mikhaylova M, Kreutz MR. 2014. Molecular dynamics of the neuronal EF-hand Ca2+-sensor Caldendrin. PLoS ONE. 9(7). https://doi.org/10.1371/journal.pone.0103186

    Rosenberg T, Gal-Ben-Ari S, Dieterich DC, Kreutz MR, Ziv NE, Gundelfinger ED, Rosenblum K. 2014. The roles of protein expression in synaptic plasticity and memory consolidation. Frontiers in Molecular Neuroscience. 7(November). https://doi.org/10.3389/fnmol.2014.00086

    Yuanxiang P, Bera S, Karpova A, Kreutz MR, Mikhaylova M. 2014. Isolation of CA1 nuclear enriched fractions from hippocampal slices to study activity-dependent nuclear import of synapto-nuclear messenger proteins. Journal of Visualized Experiments. (90). https://doi.org/10.3791/51310

     

    2013

    Fan W. 2013. Group I metabotropic glutamate receptors modulate late phase long-term potentiation in hippocampal CA1 pyramidal neurons: Comparison of apical and basal dendrites. Neuroscience Letters. 553:132-137. https://doi.org/10.1016/j.neulet.2013.08.030

    Heine M, Karpova A, Gundelfinger ED. 2013. Counting gephyrins, one at a time: A nanoscale view on the inhibitory postsynapse. Neuron. 79(2):213-216. doi.org/10.1016/j.neuron.2013.07.004

    Hradsky J, Mikhaylova M, Karpova A, Kreutz MR, Zuschratter W. 2013. Super-resolution microscopy of the neuronal calcium-binding proteins calneuron-1 and caldendrin. In Methods in Molecular Biology. pp. 147-169. (Methods in molecular biology (Clifton, N.J.)). https://doi.org/10.1007/978-1-62703-230-8_10

    Karpova A, Mikhaylova M, Bera S, Bär J, Reddy PP, Behnisch T, Rankovic V, Spilker C, Bethge P, Sahin J, Kaushik R, Zuschratter W, Kähne T, Naumann M, Gundelfinger ED, Kreutz MR. 2013. Encoding and transducing the synaptic or extrasynaptic origin of NMDA receptor signals to the nucleus. Cell. 152(5):1119-1133. https://doi.org/10.1016/j.cell.2013.02.002

    van Spronsen M*, Mikhaylova M*, Lipka J, Schlager MA, van den Heuvel DJ, Kuijpers M, Wulf PS, Keijzer N, Demmers J, Kapitein LC, Jaarsma D, Gerritsen HC, Akhmanova A, Hoogenraad CC. 2013. TRAK/Milton Motor-Adaptor Proteins Steer Mitochondrial Trafficking to Axons and Dendrites. Neuron. 77(3):485-502. https://doi.org/10.1016/j.neuron.2012.11.027            *equal conribution

     

    2012

    Bernstein HG, Smalla KH, Dürrschmidt D, Keilhoff G, Dobrowolny H, Steiner J, Schmitt A, Kreutz MR, Bogerts B. 2012. Increased density of prohibitin-immunoreactive oligodendrocytes in the dorsolateral prefrontal white matter of subjects with schizophrenia suggests extraneuronal roles for the protein in the disease. NeuroMolecular Medicine. 14(4):270-280. Available from: 10.1007/s12017-012-8185-y

    Chen Y, Yuanxiang P, Knöpfel T, Thomas U, Behnisch T. 2012. Hippocampal LTP triggers proteasome-mediated SPAR degradation in CA1 neurons. Synapse. 66(2):142-150. Available from: 10.1002/syn.20994

    Ehling P, Kanyshkova T, Baumann A, Landgraf P, Meuth SG, Pape HC, Budde T. 2012. Adenylyl cyclases: Expression in the developing rat thalamus and their role in absence epilepsy. Journal of Molecular Neuroscience. 48(1):45-52. Available from: 10.1007/s12031-012-9767-8

    Gorny X, Mikhaylova M, Seeger C, Reddy PP, Reissner C, Schott BH, Helena Danielson U, Kreutz MR, Seidenbecher C. 2012. AKAP79/150 interacts with the neuronal calcium-binding protein caldendrin. Journal of Neurochemistry. 122(4):714-726. Available from: 10.1111/j.1471-4159.2012.07828.x

    Karpova A, Bär J, Kreutz MR. 2012. Long-distance signaling from synapse to nucleus via protein messengers. In Advances in Experimental Medicine and Biology. Springer. pp. 355-376. (Advances in Experimental Medicine and Biology). Available from: 10.1007/978-3-7091-0932-8_16

    Kreutz MR, Koch KW, Naranjo JR, Schwaller B. 2012. Editorial for the Research topic 'The neuronal functions of EF-hand Ca2+-binding proteins' in Frontiers in Molecular Neuroscience. Frontiers in Molecular Neuroscience. (AUG 2012):1-2. Available from: 10.3389/fnmol.2012.00092

    Kreutz MR, Naranjo JR, Koch KW, Schwaller B. 2012. The neuronal functions of EF-hand Ca 2+-binding proteins. Frontiers in Molecular Neuroscience. (SEPTEMBER):1.

    Kreutz MR, Sala C, ed. 2012. Synaptic Plasticity: Dynamics, Development and Disease. Wien: Springer. 622 p. (Advances in Experimental Medicine and Biology). Available from: 10.1007/978-3-7091-0932-8

    Kreutz MR, Sala C. 2012. Postsynaptic molecular mechanisms. Preface. Advances in Experimental Medicine and Biology. 970.

    Macharadze T, Pielot R, Wanger T, Scheich H, Gundelfinger ED, Budinger E, Goldschmidt J, Kreutz MR. 2012. Altered neuronal activity patterns in the visual cortex of the adult rat after partial optic nerve crush-a single-cell resolution metabolic mapping study. Cerebral Cortex. 22(8):1824-1833. Available from: 10.1093/cercor/bhr256

    Navarro G, Hradsky J, Lluís C, Casadó V, McCormick PJ, Kreutz MR, Mikhaylova M. 2012. NCS-1 associates with adenosine A 2A receptors and modulates receptor function. Frontiers in Molecular Neuroscience. (APRIL). Available from: 10.3389/fnmol.2012.00053

    Raghuram V, Sharma Y, Kreutz MR. 2012. Ca 2+ sensor proteins in dendritic spines: A race for Ca 2+. Frontiers in Molecular Neuroscience. (MAY 2012). Available from: 10.3389/fnmol.2012.00061

    Schmeisser MJ, Ey E, Wegener S, Bockmann J, Stempel AV, Kuebler A, Janssen AL, Udvardi PT, Shiban E, Spilker C, Balschun D, Skryabin BV, Dieck ST, Smalla KH, Montag D, Leblond CS, Faure P, Torquet N, Le Sourd AM, Toro R, Grabrucker AM, Shoichet SA, Schmitz D, Kreutz MR, Bourgeron T, Gundelfinger ED, Boeckers TM. 2012. Autistic-like behaviours and hyperactivity in mice lacking ProSAP1/Shank2. Nature. 486(7402):256-260. Available from: 10.1038/nature11015

    Seeger C, Gorny X, Reddy PP, Seidenbecher C, Danielson UH. 2012. Kinetic and mechanistic differences in the interactions between caldendrin and calmodulin with AKAP79 suggest different roles in synaptic function. Journal of Molecular Recognition. 25(10):495-503. Available from: 10.1002/jmr.2215

     

    2011

    Behnisch T, YuanXiang P, Bethge P, Parvez S, Chen Y, Yu J, Karpova A, Frey JU, Mikhaylova M, Kreutz MR. 2011. Nuclear translocation of Jacob in hippocampal neurons after stimuli inducing long-term potentiation but not long-term depression. PLoS ONE. 6(2). Available from: 10.1371/journal.pone.0017276

    Dash-Wagh S, Neumann JR, Veitinger S, Grote-Westrick C, Landgraf P, Pape HC, Kreutz MR, von Holst A, Wahle P. 2011. The survival promoting peptide Y-P30 promotes cellular migration. Molecular and Cellular Neurosciences. 48(3):195-204. Available from: 10.1016/j.mcn.2011.07.005

    Engmann O, Hortobágyi T, Pidsley R, Troakes C, Bernstein HG, Kreutz MR, Mill J, Nikolic M, Giese KP. 2011. Schizophrenia is associated with dysregulation of a Cdk5 activator that regulates synaptic protein expression and cognition. Brain. 134(8):2408-2421. Available from: 10.1093/brain/awr155

    Fainzilber M, Budnik V, Segal RA, Kreutz MR. 2011. From synapse to nucleus and back again-communication over distance within neurons. Journal of Neuroscience. 31(45):16045-16048. Available from: 10.1523/JNEUROSCI.4006-11.2011

    Grabrucker AM, Knight MJ, Proepper C, Bockmann J, Joubert M, Rowan M, Nienhaus GU, Garner CC, Bowie JU, Kreutz MR, Gundelfinger ED, Boeckers TM. 2011. Concerted action of zinc and ProSAP/Shank in synaptogenesis and synapse maturation. EMBO Journal. 30(3):569-581. Available from: 10.1038/emboj.2010.336

    Hradsky J, Raghuram V, Pasham P, Navarro G, Hupe M, Casado V, McCormick PJ, Sharma Y, Kreutz MR, Mikhaylova M. 2011. Post-translational membrane insertion of tail-anchored transmembrane EF-hand Ca 2+ sensor calneurons requires the TRC40/Asna1 protein chaperone. Journal of Biological Chemistry. 286(42):36762-36776. Available from: 10.1074/jbc.M111.280339

    Macharadze T, Landgraf P, Pape HC, Wahle P, Kreutz MR. 2011. Y-P30 confers neuroprotection after optic nerve crush in adult rats. NeuroReport. 22(11):544-547. Available from: 10.1097/WNR.0b013e328348b512

    Mikhaylova M, Hradsky J, Kreutz MR. 2011. Between promiscuity and specificity: Novel roles of EF-hand calcium sensors in neuronal Ca 2+ signalling. Journal of Neurochemistry. 118(5):695-713. Available from: 10.1111/j.1471-4159.2011.07372.x

    Rankovic V, Landgraf P, Kanyshkova T, Ehling P, Meuth SG, Kreutz MR, Budde T, Munsch T. 2011. Modulation of calcium-dependent inactivation of L-type Ca 2+ channels via β-adrenergic signaling in thalamocortical relay neurons. PLoS ONE. 6(12). Available from: 10.1371/journal.pone.0027474

    Rönicke R, Mikhaylova M, Rönicke S, Meinhardt J, Schröder UH, Fändrich M, Reiser G, Kreutz MR, Reymann KG. 2011. Early neuronal dysfunction by amyloid β oligomers depends on activation of NR2B-containing NMDA receptors. Neurobiology of Aging. 32(12):2219-2228. Available from: 10.1016/j.neurobiolaging.2010.01.011

    Sobczak A, Debowska K, Blazejczyk M, Kreutz MR, Kuznicki J, Wojda U. 2011. Calmyrin1 binds to SCG10 protein (stathmin2) to modulate neurite outgrowth. Biochimica et Biophysica Acta - Molecular Cell Research. 1813(5):1025-1037. Available from: 10.1016/j.bbamcr.2010.12.023

     

    2010

    Dürrschmidt D, Smalla KH, Kreutz MR, Dobrowolny H, Steiner J, Keilhoff G, Bogerts B, Bernstein HG. 2010. Increased oligodendroglial expression of the cell proliferation?controlling protein prohibitin in schizophrenia. A hint for cell cycle abnormalities?. Acta Clinica Croatica. 49(SUPPL. 2):39-41.

    Fries R, Reddy PP, Mikhaylova M, Haverkamp S, Wei T, Müller M, Kreutz MR, Koch KW. 2010. Dynamic cellular translocation of caldendrin is facilitated by the Ca 2+-myristoyl switch of recoverin. Journal of Neurochemistry. 113(5):1150-1162. Available from: 10.1111/j.1471-4159.2010.06676.x

    Mikhaylova M, Reddy PP, Kreutz MR. 2010. Role of neuronal Ca2+-sensor proteins in Golgi-cell-surface membrane traffic. Biochemical Society Transactions. 38(1):177-180. Available from: 10.1042/BST0380177

    Rankovic V, Ehling P, Coulon P, Landgraf P, Kreutz MR, Munsch T, Budde T. 2010. Intracellular Ca2+ release-dependent inactivation of Ca 2+ currents in thalamocortical relay neurons. European Journal of Neuroscience. 31(3):439-449. Available from: 10.1111/j.1460-9568.2010.07081.x

    Spilker C, Kreutz MR. 2010. RapGAPs in brain: Multipurpose players in neuronal Rap signalling. European Journal of Neuroscience. 32(1):1-9. Available from: 10.1111/j.1460-9568.2010.07273.x

     

     

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