Abteilung Systemphysiologie des Lernens

Gruppenbild der Abteilung Systemphysiologie
Mitglieder der Abteilung

In der Abteilung „Systemphysiologie des Lernens" untersuchen wir neuronale Mechanismen verschiedenster Phänomene im Kontext von Lernen und Gedächtnis. Hierbei fokussieren wir vor allem auf die Ebene von neuronalen Schaltkreisen sowohl innerhalb ausgewählter Hirnregionen als auch als Verbindungsstrukturen zwischen Hirnregionen. Zur Erforschung der neuronalen Grundlagen von Lernvorgängen kombinieren wir Verhaltens-Experimente, wie Detektions- und Diskriminationslernen sowie Kategorienbildung, mit elektrophysiologischen Messungen (von Einzelzellen, Zell-Assemblies, lokalen Feldpotentialen, Elektrocorticogrammen und EEGs), mit optischen Ableitung (spannungs-abhängige Farbstoffe und Ca2+-Imaging) und optogenetischen, elektrischen und pharmakologischen Interventionsstrategien.

In den letzten Jahren haben wir u.a. erfolgreich Projekte in den koordinierten Programmen SFB TRR 31 (Das aktive Gehör), SFB TRR 62 (Eine Companion-Technologie für technische kognitive Systeme), und SFB 779 (Neurobiologie motivierten Verhaltens), sowie der USA-German Collaboration on Computational Neuroscience.

  • Leiter

    Leiter

    Frank Ohl

    Frank Ohl studierte Biologie an der Technischen Universität Darmstadt, wo er sein Diplom zu Arbeiten über lern-induzierte Plastizität in rezeptiven Feldern corticaler Neurone erhielt und über nichtlineare Interaktionen zwischen spektralen Komponenten in komplexen akustischen Reizen promovierte. Seinen Postdoc-Aufenthalt verbrachte er bei Walter J. Freeman an der UC Berkeley in USA, wo er über corticale Neurodynamik im Kontext von Wahrnehmung und Lernen arbeitete. Er ist fasziniert davon, wie in den modernen Neurowissenschaften neueste Untersuchungstechnologien auf jahrhundertealte Fragen über die Natur des Geistes treffen, und ist ein Verfechter der Auffassung, dass moderne Hirnforschung in Forschung und Lehre die traditionellen Disziplinen der Naturwissenschaften transzendieren muss.

    Seine Lehraktivitäten fokussieren auf systemische Neurowissenschaften, aber erstrecken sich darüber hinaus über viele interdisziplinäre Themen von klassischer Elektrodynamik bis zur Philosophie oder den Implikationen neurowissenschaftlicher Forschung für die Rechtsprechung. Seine Abteilung versammelt eine Gruppe höchst motivierter Wissenschaftler mit einem konvergierenden Interesse an systemischer Neurophysiologie auf der Schaltkreisebene.

    Frank Ohl war Sprecher des kürzlich abgeschlossenen SFB 779 (Neurobiologie motivierten Verhaltens), Standort-Sprecher des SFB-TRR 31 (Das aktive Gehör, Oldenburg-Magdeburg) und Koordinator des Leibniz Postdoc-Netzwerkes (LPN, Impact of monoamines on neural circuits).

  • Mitglieder

    Mitglieder

    Leiter  
    Prof. Dr. Frank Ohl+49-391-6263-95481frank.ohl@lin-magdeburg.de
    Sekretariat  
    Beate Traoré (Sekretariat der Abteilung)+49-391-6263-95481beate.traore@lin-magdeburg.de
    Wissenschaftliche Mitarbeiter  
    PD Dr. Max Happel+49-391-6263-94411max.happel@lin-magdeburg.de
    Dr. Michael Lippert+49-391-6263-94391michael.lippert@lin-magdeburg.de
    Dr. Andreas Schulz   +49-391-6263-94381andreas.schulz@lin-magdeburg.de
    Doktoranden  
    Tamer Ayberk Kaya   +49-391-6263-94401TamerAyberk.Kaya@lin-magdeburg.de    
    Tony de Schultz           +49-391-6263-94401tony.schultz@lin-magdeburg.de
    Alisa Vlasenko+49-391-6263-93481alisa.vlasenko@lin-magdeburg.de
    Zifeng Xia+49-391-6263-93481zifeng.xia@lin-magdeburg.de
    Technische Mitarbeiter  
    Anja Gürke+49-391-6263-95461anja.guerke@lin-magdeburg.de
    Ute Lerke+49-391-6263-95081ute.lerke@lin-magdeburg.de
    Kathrin Ohl+49-391-6263-95461kathrin.ohl@lin-magdeburg.de
    Gäste  
    PD Dr. Maike Vollmer+49-391-6263-95491 
    Dr. Tamar Macharadze  
    Dr. Dr. Kentaroh Takagaki  

     

  • Projekte

    Projekte

    SFB 779: Neurobiologie motivierten Verhaltens
    Der Sonderforschungsbereich 779, dessen Sprecher Frank Ohl ist, ist nach erfolgreicher Evaluation nun in die dritte Förderperiode gegangen. In diesem Sonderforschungsbereich werden die neuronalen Grundlagen von Motivationsprozessen, sowie ihre Pathologien und klinische Behandlung, von interdisziplinären Teams aus vor allem Biologen, Psychologen und Medizinern untersucht. In den Teilprojekten der Abteilung geht es vorwiegend um die Erforschung der Interaktion zwischen sensorischen und motivationssteuernden Systemen. Der Sonderforschungsbereich enthält zu dem ein integriertes Graduiertenkolleg, das im SFB promovierenden Studierenden eine strukturiertes Ausbildungs- und Betreuungskonzept bis zum Abschluss ihrer Promotion bietet.

     

    DFG-Programm: "Resolving and manipulating neuronal networks in the mammalien brain"
    Ebenfalls ist unser Projekt im Rahmen des DFG-Schwerpunkt-Programms 1665 "Resolving and manipulating neuronal networks in the mammalien brain" erfolgreich in die nächste Förderperiode gegangen. Hier wollen wir über die in den Neurowissenschaften verbreiteten korrelativen Forschungsansätze hinausgehen, und kausale Mechanismen untersuchen, das heißt durch gezielte Manipulation von Hirnprozessen Lernleistungen im Individuum beeinflussen.

     

    Leibniz Postdoc Netzwerk
    Das Leibniz Postdoctoral Network (LPN), dessen Koordinator Frank Ohl ist, untersucht in mehreren Postdoc-Projekten den Einfluss monoaminerger Neurotransmitter, einer wichtigen Klasse von Botenstoffen des Gehrins, auf verschiedene neuronale Schaltkreise des Gehirns. Das Postdoc-Netzwerk dient neben der Organiation einer gruppenübergreifenden Forschungsaktivität vor allem auch der Unterstützung der Karriereentwicklung der beteiligten Postdocs. Wir versuchen hiermit eine wichtige Lücke in den Karriere-Entwicklungsprogrammen der Forschungsförderung für junge Wissenschaftler beim Übergang von der Postdoc-Zeit in die unabhängige Gruppenleiterposition zu schließen.

     

    Graduiertenschule ABINEP
    Im Rahmen der EU-geförderten Internationalen Graduiertenschule ABINEP untersuchen wir den Einfluss des Neurotransmitters Dopamin auf die Kommunikation zwischen sensorischen und bedeutungs-bewertenden Strukturen im Gehirn.

     

    Projekt IAIS: Intention-based anticipatory interactive systems
    Die Interaktion zwischen Computer-Wissenschaften, künstlicher Intelligenz und Neurowissenschaften ist eines unserer Haupt-Kollaborationsfelder und unserer Meinung nach im höchsten Maße zukunftsweisend, sowohl für die neurowissenschaftliche Forschung, wie auch für die Entwicklung unserer Gesellschaft im Allgemeinen. Im neuen Projekt IAIS ("Intention-based anticipatory interactive systems") untersuchen wir in Zusammenarbeit mit Kollegen der Otto-von-Guericke-Universität, welche Mechanismen der flexiblen Anpassung von Verhaltensstrategien in biologischen Organismen zu Grunde liegen, und wie diese Mechanismen für künstlich intelligente Systeme nutzbar gemacht werden können.

  • Drittmittelprojekte

    Drittmittelprojekte

    2008-2019
    DFG SFB 779 Neurobiologie motiverten Verhaltens
    Sprecher und TP B1 Interaktion sensorischer und Verstärker-evaluierender Systeme beim auditorischen Lernen
    http://www.sfb779.de/b01.html
    http://gepris.dfg.de/gepris/projekt/63894603

     

    2008-2019
    DFG SFB 779 Neurobiologie motiverten Verhaltens
    Integriertes Graduiertenkolleg (zusammen mit Bertram Gerber)
    http://www.sfb779.de
    http://gepris.dfg.de/gepris/projekt/216342879

     

    2008-2019
    DFG SFB 779 Neurobiologie motiverten Verhaltens
    Z2 Zentralprojekt
    http://www.sfb779.de
    http://gepris.dfg.de/gepris/projekt/63935694

     

    2017-2021
    ABINEP: Analysis, imaging, and modelling of neuronal and inflammatory processes
    Dopamine-dependent modulation of neuronal switches in the auditory cortex and the striatum
    https://www.abinep.ovgu.de/

     

    2016-2019
    DFG SPP 1665 Resolving and manipulating neuronal networks in the mammalian brain
    TP Causative mechanisms of mesoscopic activity patterns in auditory category discrimination (zusammen mit Bertram Schmidt und Sonja Grün)
    http://www.spp1665.de/projects_causative.html

     

    2018-2020
    Intentional anticipatory interactive systems (IAIS)
    Neurobiologie des Strategiewechsels. Unterstützung und Intervention

     

    2015-2018
    WGL The Leibniz Postdoctoral Network (LPN) at the LIN
    Monoaminergic impact on neuronal circuits
    http://lpn.lin-magdeburg.de/

     

    2013-2019
    DFG SPP 1608 "Ultrafast and temporally precise information processing: Normal and dysfunctional hearing"
    "Age-dependent effects of unilateral hearing loss on the processing of interaural time differences and possible readjustments by subsequent electric cochlear stimulation" (Vollmer)
    http://www.pp1608.com/the-group/maike-vollmer.html

    "Mechanisms of the phase–locking of auditory-nerve fibers: a modeling approach" (Heil)
    http://www.pp1608.com/the-group/peter-heil.html

     

    2013-2019
    DFG SPP 1665
    "Causative Mechanisms of Mesoscopic Activity Patterns in Auditory Category Discrimination" (Ohl/Takagaki)
    http://www.spp1665.de/projects_causative.html

  • Publikationen

    Publikationen

    Ausgewählte Publikationen

    Peterson AJ, Heil P. 2020. Phase locking of auditory-nerve fibers: the role of lowpass filtering by hair cells. Journal of Neuroscience. 40(24):4700-4714. https://doi.org/10.1523/JNEUROSCI.2269-19.2020

    Deane KE, Brunk MGK, Curran AW, Zempeltzi MM, Ma J, Lin X, Abela F, Aksit S, Deliano M, Ohl FW, Happel MFK. 2020. Ketamine anaesthesia induces gain enhancement via recurrent excitation in granular input layers of the auditory cortex. Journal of Physiology. 598(13):2741-2755. https://doi.org/10.1113/JP279705

    Deliano M, Brunk MGK, El-Tabbal M, Zempeltzi MM, Happel MFK, Ohl FW. 2020. Dopaminergic neuromodulation of high gamma stimulus phase-locking in gerbil primary auditory cortex mediated by D1/D5-receptors. European Journal of Neuroscience. 51(5):1315-1327. https://doi.org/10.1111/ejn.13898

    Weidner TC, Vincenz D, Brocka M, Tegtmeier J, Oelschlegel AM, Ohl FW, Goldschmidt J, Lippert MT. 2020. Matching stimulation paradigms resolve apparent differences between optogenetic and electrical VTA stimulation. Brain Stimulation. 13(2):363-371. https://doi.org/10.1016/j.brs.2019.11.005

    Brunk MGK, Deane KE, Kisse M, Deliano M, Vieweg S, Ohl FW, Lippert MT, Happel MFK. 2019. Optogenetic stimulation of the VTA modulates a frequency-specific gain of thalamocortical inputs in infragranular layers of the auditory cortex. Scientific Reports. 9(1):Article 20385. https://doi.org/10.1038/s41598-019-56926-6

    Niekisch H, Steinhardt J, Berghäuser J, Bertazzoni S, Kaschinski E, Kasper J, Kisse M, Mitlöhner J, Singh JB, Weber J, Frischknecht R, Happel MFK. 2019. Learning induces transient upregulation of brevican in the auditory cortex during consolidation of long-term memories. Journal of Neuroscience. 39(36):7049-7060. https://doi.org/10.1523/JNEUROSCI.2499-18.2019

    Brocka M, Helbing C, Vincenz D, Scherf T, Montag D, Goldschmidt J, Angenstein F*, Lippert M*. 2018. Contributions of dopaminergic and non-dopaminergic neurons to VTA-stimulation induced neurovascular responses in brain reward circuits. NeuroImage. 177:88-97. https://doi.org/10.1016/j.neuroimage.2018.04.059     *shared corresponding authorship

    Heil P, Matysiak A, Neubauer H. 2017. A probabilistic Poisson-based model accounts for an extensive set of absolute auditory threshold measurements. Hearing Research. 353:135-161. https://doi.org/10.1016/j.heares.2017.06.011

    Ohl FW. 2015. Role of cortical neurodynamics for understanding the neural basis of motivated behavior - lessons from auditory category learning. Current Opinion in Neurobiology. 31:88-94. doi.org/10.1016/j.conb.2014.08.014

    Happel MFK, Niekisch H, Castiblanco Rivera LL, Ohl FW, Deliano M, Frischknecht R. 2014. Enhanced cognitive flexibility in reversal learning induced by removal of the extracellular matrix in auditory cortex. Proceedings of the National Academy of Sciences of the United States of America. 111(7):2800-2805. https://doi.org/10.1073/pnas.1310272111

     

    Alle Publikationen der Abteilung

    2023

    Danyeli LV, Sen ZD, Colic L, Kurzweil L, Gensberger-Reigl S, Macharadze T, Götting F, Refisch A, Liebe T, Chand T, Kretzschmar M, Wagner G, Opel N, Jollant F, Speck O, Munk M HJ, Li M, Walter M. 2023. Association of the delayed changes in glutamate levels and functional connectivity with the immediate network effects of S-ketamine. Translational Psychiatry. 13(1):Article 60. https://doi.org/10.1038/s41398-023-02346-0

    Grochowska KM, Gomes GM, Raman R, Kaushik R, Sosulina L, Kaneko H, Oelschlegel AM, Yuanxiang P, Reyes-Resina I, Bayraktar G, Samer S, Spilker C, Woo MS, Morawski,M, Goldschmidt J, Friese MA, Rossner S, Navarro G, Remy S, Reissner C, Karpova A, Kreutz MR. 2023. Jacob-induced transcriptional inactivation of CREB promotes Aβ-induced synapse loss in Alzheimer's disease. The EMBO journal. 42(4):Article e112453. https://doi.org/10.15252/embj.2022112453

    Klingner CM, Denker M, Grün S, Hanke M, Oeltze-Jafra S, Ohl FW, Radny J, Rotter S, Scherberger H, Stein A, Wachtler T, Witte OW, Ritter P. 2023. Research Data Management and Data Sharing for Reproducible Research - Results of a Community Survey of the German National Research Data Infrastructure Initiative Neuroscience. eNeuro. 10(2):Article ENEURO.0215-22.2023. https://doi.org/10.1523/ENEURO.0215-22.2023

     

    2022

    Caras ML, Happel MFK, Chandrasekaran B, Ripollés P, Keesom SM, Hurley LM, Remage-Healey L, Holt LL, Wright BA. 2022. Non-sensory Influences on Auditory Learning and Plasticity. JARO - Journal of the Association for Research in Otolaryngology. 23(2):151-166. https://doi.org/10.1007/s10162-022-00837-3

    Happel MFK, Hechavarria JC, de Hoz L. 2022. Editorial: Cortical-Subcortical Loops in Sensory Processing. Frontiers in neural circuits. 16:Article 851612. https://doi.org/10.3389/fncir.2022.851612

    Jeschke M, Ohl FW, Wang X. 2022. Effects of Cortical Cooling on Sound Processing in Auditory Cortex and Thalamus of Awake Marmosets. Frontiers in neural circuits. 15:Article 786740. https://doi.org/10.3389/fncir.2021.786740

    Kowark A, Berger M, Rossaint R, Schmid M, Coburn M, Matcharadze T, POSE-Study group. 2022. Association between benzodiazepine premedication and 30-day mortality rate: A propensity-score weighted analysis of the Peri-interventional Outcome Study in the Elderly (POSE). European journal of anaesthesiology. 39(3):210-218. https://doi.org/10.1097/EJA.0000000000001638

    Saldeitis K, Jeschke M, Michalek A, Henschke JU, Wetzel W, Ohl FW, Budinger E. 2022. Selective interruption of auditory interhemispheric crosstalk impairs discrimination learning of frequency-modulated tone direction but not gap detection and discrimination. Journal of Neuroscience. 42(10):2025-2038. https://doi.org/10.1523/JNEUROSCI.0216-21.2022

     

    2021

    Atucha E, Ku S-P, Lippert M, Sauvage M. 2021. Remembering the gist of an event over a lifetime depends on the hippocampus. bioRxiv. https://doi.org/10.1101/2021.04.14.439803

    Brosch M, Vlasenko A, Ohl FW, Lippert MT. 2021. TetrODrive: an open-source microdrive for combined electrophysiology and optophysiology. Journal of Neural Engineering. 18(4):Article 046030. https://doi.org/10.1088/1741-2552/abf608

    El-Tabbal M, Niekisch H, Henschke JU, Budinger E, Frischknecht R, Deliano M, Happel MFK. 2021. The extracellular matrix regulates cortical layer dynamics and cross-columnar frequency integration in the auditory cortex. Communications biology. 4(1):Article 322. https://doi.org/10.1038/s42003-021-01837-4

    Heil P, Mohamed ESI, Matysiak A. 2021. Towards a unifying basis of auditory thresholds: Thresholds for multicomponent stimuli. Hearing Research. 410:Article 108349. https://doi.org/10.1016/j.heares.2021.108349

    Heil P. 2021. Comparing and modeling absolute auditory thresholds in an alternative-forced-choice and a yes-no procedure. Hearing Research. 403:Article 108164. https://doi.org/10.1016/j.heares.2020.108164

    Jeschke M, Happel MFK, Tziridis K, Krauss P, Schilling A, Schulze H, Ohl FW. 2021. Acute and Long-Term Circuit-Level Effects in the Auditory Cortex After Sound Trauma. Frontiers in Neuroscience. 14:Article 598406. https://doi.org/10.3389/fnins.2020.598406

    Kozma R, Hu S, Sokolov Y, Wanger T, Schulz AL, Woldeit ML, Gonçalves AI, Ruszinkó M, Ohl FW. 2021. State Transitions During Discrimination Learning in the Gerbil Auditory Cortex Analyzed by Network Causality Metrics. Frontiers in Systems Neuroscience. 15:Article 641684. https://doi.org/10.3389/fnsys.2021.641684

    Kreutzmann JC, Fendt M. 2021. Intranasal oxytocin compensates for estrus cycle-specific reduction of conditioned safety memory in rats: Implications for psychiatric disorders. Neurobiology of stress. 14:Article 100313. https://doi.org/10.1016/j.ynstr.2021.100313

    Kreutzmann JC, Marin MF, Fendt M, Milad MR, Ressler K, Jovanovic T. 2021. Unconditioned response to an aversive stimulus as predictor of response to conditioned fear and safety: A cross-species study. Behavioural Brain Research. 402:Article 113105. https://doi.org/10.1016/j.bbr.2020.113105

    Lin X, Brunk MGK, Yuanxiang P, Curran AW, Zhang E, Stöber F, Goldschmidt J, Gundelfinger ED, Vollmer M, Happel MFK, Herrera-Molina R, Montag D. 2021. Neuroplastin expression is essential for hearing and hair cell PMCA expression. Brain Structure and Function. 226(5):1533-1551. https://doi.org/10.1007/s00429-021-02269-w

    Peterson AJ, Heil P. 2021. A simplified physiological model of rate-level functions of auditory-nerve fibers. Hearing Research. 406:Article 108258. https://doi.org/10.1016/j.heares.2021.108258

    Peterson AJ. 2021. A numerical method for computing interval distributions for an inhomogeneous Poisson point process modified by random dead times. Biological Cybernetics. 115(2):177-190. https://doi.org/10.1007/s00422-021-00868-8

    Prior MJW, Bast T, McGarrity S, Goldschmidt J, Vincenz D, Seaton A, Hall G, Pitiot A. 2021. Ratlas-LH: An MRI template of the Lister hooded rat brain with stereotaxic coordinates for neurosurgical implantations. Brain and neuroscience advances. 5:Article 23982128211036332. https://doi.org/10.1177/23982128211036332

    Radeloff A, Nada N, El Mahallawi T, Kolkaila E, Vollmer M, Rak K, Hagen R, Schendzielorz P. 2021. Transplantation of adipose-derived stromal cells protects functional and morphological auditory nerve integrity in a model of cochlear implantation. NeuroReport. 32(9):776-782. https://doi.org/10.1097/WNR.0000000000001651

    Saldeitis K, Jeschke M, Budinger E, Ohl FW, Happel MFK. 2021. Laser-Induced Apoptosis of Corticothalamic Neurons in Layer VI of Auditory Cortex Impact on Cortical Frequency Processing. Frontiers in neural circuits. 15:Article 659280. https://doi.org/10.3389/fncir.2021.659280

    Schilling M, Melnik A, Ohl FW, Ritter HJ, Hammer B. 2021. Decentralized control and local information for robust and adaptive decentralized Deep Reinforcement Learning. Neural networks : the official journal of the International Neural Network Society. 144:699-725. https://doi.org/10.1016/j.neunet.2021.09.017

     

    2020

    Beitel RE, Schreiner CE, Vollmer M. 2020. Spectral plasticity in monkey primary auditory cortex limits performance generalization in a temporal discrimination task. Journal of Neurophysiology. 124(6):1798-1814. https://doi.org/10.1152/jn.00278.2020

    Berdugo-Vega G, Arias-Gil G, López-Fernández A, Artegiani B, Wasielewska JM, Lee C-C, Lippert MT, Kempermann G, Takagaki K, Calegari F. 2020. Increasing neurogenesis refines hippocampal activity rejuvenating navigational learning strategies and contextual memory throughout life. Nature Communications. 11(1):Article 135. https://doi.org/10.1038/s41467-019-14026-z

    Brosch M, Deckert M, Rathi S, Takagaki K, Weidner T, Ohl FW, Schmidt B, Lippert MT. 2020. An optically transparent multi-electrode array for combined electrophysiology and optophysiology at the mesoscopic scale. Journal of Neural Engineering. 17(4):Article 046014. https://doi.org/10.1088/1741-2552/aba1a4

    Deane KE, Brunk MGK, Curran AW, Zempeltzi MM, Ma J, Lin X, Abela F, Aksit S, Deliano M, Ohl FW, Happel MFK. 2020. Ketamine anaesthesia induces gain enhancement via recurrent excitation in granular input layers of the auditory cortex. Journal of Physiology. 598(13):2741-2755. https://doi.org/10.1113/JP279705

    Deliano M, Brunk MGK, El-Tabbal M, Zempeltzi MM, Happel MFK, Ohl FW. 2020. Dopaminergic neuromodulation of high gamma stimulus phase-locking in gerbil primary auditory cortex mediated by D1/D5-receptors. European Journal of Neuroscience. 51(5):1315-1327. https://doi.org/10.1111/ejn.13898

    Dürschmid S, Reichert C, Walter N, Hinrichs H, Heinze H-J, Ohl FW, Tononi G, Deliano M. 2020. Self-regulated critical brain dynamics originate from high frequency-band activity in the MEG. PLoS ONE. 15(6):e0233589. https://doi.org/10.1371/journal.pone.0233589

    Goldschmidt J, Oelschlegel A. 2020. Functional Neuroimaging in Rodents Using Cerebral Blood Flow SPECT. Frontiers in Physics. 8:Article 152. https://doi.org/10.3389/fphy.2020.00152

    Heil P, Matysiak A. 2020. Absolute auditory threshold: Testing the absolute. European Journal of Neuroscience. 51(5):1224-1233. https://doi.org/10.1111/ejn.13765

    Knyazeva S, Selezneva E, Gorkin A, Ohl FW, Brosch M. 2020. Representation of Auditory Task Components and of Their Relationships in Primate Auditory Cortex. Frontiers in Neuroscience. 14:Article 306. https://doi.org/10.3389/fnins.2020.00306

    Kreutzmann JC, Fendt M. 2020. Chronic inhibition of GABA synthesis in the infralimbic cortex facilitates conditioned safety memory and reduces contextual fear. Translational Psychiatry. 10(1):Article 120. https://doi.org/10.1038/s41398-020-0788-8

    Kreutzmann JC, Khalil R, Köhler JC, Mayer D, Florido A, Nadal R, Andero R, Fendt M. 2020. Neuropeptide-S-Receptor Deficiency Affects Sex-Specific Modulation of Safety Learning by Pre-Exposure to Electric Stimuli. Genes, Brain and Behavior. 19(3):e12621. https://doi.org/10.1111/gbb.12621

    Mitlöhner J, Kaushik R, Niekisch H, Blondiaux A, Gee CE, Happel MFK, Gundelfinger E, Dityatev A, Frischknecht R, Seidenbecher C. 2020. Dopamine Receptor Activation Modulates the Integrity of the Perisynaptic Extracellular Matrix at Excitatory Synapses. Cells. 9(2):Article 260. https://doi.org/10.3390/cells9020260

    Peterson AJ, Heil P. 2020. Phase locking of auditory-nerve fibers: the role of lowpass filtering by hair cells. Journal of Neuroscience. 40(24):4700-4714. https://doi.org/10.1523/JNEUROSCI.2269-19.2020

    Rufener KS, Kauk J, Ruhnau P, Repplinger S, Heil P, Zaehle T. 2020. Inconsistent effects of stochastic resonance on human auditory processing. Scientific Reports. 10(1):Article 6419. https://doi.org/10.1038/s41598-020-63332-w

    Weidner TC, Vincenz D, Brocka M, Tegtmeier J, Oelschlegel AM, Ohl FW, Goldschmidt J, Lippert MT. 2020. Matching stimulation paradigms resolve apparent differences between optogenetic and electrical VTA stimulation. Brain Stimulation. 13(2):363-371. https://doi.org/10.1016/j.brs.2019.11.005

    Zempeltzi MM, Kisse M, Brunk MGK, Glemser C, Aksit S, Deane KE, Maurya S, Schneider L, Ohl FW, Deliano M, Happel MFK. 2020. Task rule and choice are reflected by layer-specific processing in rodent auditory cortical microcircuits. Communications biology. 3(1):Article 345. https://doi.org/10.1038/s42003-020-1073-3

     

    2019

    Andres-Alonso M, Ammar MR, Butnaru I, Gomes GM, Acuña Sanhueza G, Raman R, Yuanxiang P, Borgmeyer M, Lopez-Rojas J, Raza SA, Brice N, Hausrat TJ, Macharadze T, Diaz-Gonzalez S, Carlton M, Failla AV, Stork O, Schweizer M, Gundelfinger ED, Kneussel M, Spilker C, Karpova A, Kreutz MR. 2019. SIPA1L2 controls trafficking and local signaling of TrkB-containing amphisomes at presynaptic terminals. Nature Communications. 10(1):Article 5448. doi.org/10.1038/s41467-019-13224-z

    Binder S, Mölle M, Lippert M, Bruder R, Aksamaz S, Ohl F, Wiegert JS, Marshall L. 2019. Monosynaptic hippocampal-prefrontal projections contribute to spatial memory consolidation in mice. Journal of Neuroscience. 39(35):6978-6991. https://doi.org/10.1523/JNEUROSCI.2158-18.2019

    Brunk MGK, Deane KE, Kisse M, Deliano M, Vieweg S, Ohl FW, Lippert MT, Happel MFK. 2019. Optogenetic stimulation of the VTA modulates a frequency-specific gain of thalamocortical inputs in infragranular layers of the auditory cortex. Scientific Reports. 9(1):Article 20385. https://doi.org/10.1038/s41598-019-56926-6

    Coors A, Brosch M, Kahl E, Khalil R, Michels B, Laub A, Franke K, Gerber B, Fendt M. 2019. Rhodiola rosea root extract has antipsychotic-like effects in rodent models of sensorimotor gating. Journal of Ethnopharmacology. 235:320-328. https://doi.org/10.1016/j.jep.2019.02.031

    Heil P, Peterson AJ. 2019. Nelson's notch in the rate-level functions of auditory-nerve fibers might be caused by PIEZO2-mediated reverse-polarity currents in hair cells. Hearing Research. 381:Article 107783. https://doi.org/10.1016/j.heares.2019.107783

    Huang Y, Heil P, Brosch M. 2019. Associations between sounds and actions in early auditory cortex of nonhuman primates. eLife. 8:Article e43281. https://doi.org/10.7554/eLife.43281

    Macharadze T, Budinger E, Brosch M, Scheich H, Ohl FW, Henschke JU. 2019. Early Sensory Loss Alters the Dendritic Branching and Spine Density of Supragranular Pyramidal Neurons in Rodent Primary Sensory Cortices. Frontiers in neural circuits. 13:Article 61. https://doi.org/10.3389/fncir.2019.00061

    Niekisch H, Steinhardt J, Berghäuser J, Bertazzoni S, Kaschinski E, Kasper J, Kisse M, Mitlöhner J, Singh JB, Weber J, Frischknecht R, Happel MFK. 2019. Learning induces transient upregulation of brevican in the auditory cortex during consolidation of long-term memories. Journal of Neuroscience. 39(36):7049-7060. https://doi.org/10.1523/JNEUROSCI.2499-18.2019

    Peterson AJ, Heil P. 2019. Phase Locking of Auditory-Nerve Fibers Reveals Stereotyped Distortions and an Exponential Transfer Function with a Level-Dependent Slope. Journal of Neuroscience. 39(21):4077-4099. https://doi.org/10.1523/JNEUROSCI.1801-18.2019

    Saldeitis K, Richter K, Fischer K-D, Ohl FW, Mateos JM, Budinger E. 2019. Ultrastructure of giant thalamic terminals in the auditory cortex. European Journal of Neuroscience. 50(9):3445-3453. https://doi.org/10.1111/ejn.14509

    Schicknick H, Henschke JU, Budinger E, Ohl FW, Gundelfinger ED, Tischmeyer W. 2019. β-adrenergic modulation of discrimination learning and memory in the auditory cortex. European Journal of Neuroscience. 50(7):3141-3163. https://doi.org/10.1111/ejn.14480

    Schilling M, Ritter H, Ohl FW. 2019. From crystallized adaptivity to fluid adaptivity in deep reinforcement learning-insights from biological systems on adaptive flexibility. In 2019 IEEE International Conference on Systems, Man and Cybernetics, SMC 2019. Institute of Electrical and Electronics Engineers Inc. pp. 1472-1478. (Conference Proceedings - IEEE International Conference on Systems, Man and Cybernetics). https://doi.org/10.1109/SMC.2019.8914302

    Wendemuth A, Boeck R, Nuernberger A, Al-Hamadi A, Brechmann A, Ohl FW. 2019. Intention-Based Anticipatory Interactive Systems. In Proceedings - 2018 IEEE International Conference on Systems, Man, and Cybernetics, SMC 2018. Institute of Electrical and Electronics Engineers Inc. pp. 2583-2588. https://doi.org/10.1109/SMC.2018.00442

    Xia Z, Arias-Gil G, Deckert M, Vollmer M, Curran A, Herrera-Molina R, Brosch M, Krug K, Schmidt B, Ohl FW, Lippert MT, Takagaki K. 2019. Electrochemical Roughening and Carbon Nanotube Coating of Tetrodes for Chronic Single-Unit Recording. bioRxiv. https://doi.org/10.1101/738245
     

    2018

    Brocka M, Helbing C, Vincenz D, Scherf T, Montag D, Goldschmidt J, Angenstein F*, Lippert M*. 2018. Contributions of dopaminergic and non-dopaminergic neurons to VTA-stimulation induced neurovascular responses in brain reward circuits. NeuroImage. 177:88-97. https://doi.org/10.1016/j.neuroimage.2018.04.059     *equal contribution

    Brunk M, Sputh S, Doose S, Van De Linde S, Terpitz U. 2018. HyphaTracker: An ImageJ toolbox for time-resolved analysis of spore germination in filamentous fungi. Scientific Reports. 8(1):Article 605. doi.org/10.1038/s41598-017-19103-1

    Deckert M, Lippert MT, Krzemiñski J, Takagaki K, Ohl F, Schmidt B. 2018. Polyimide Foil Flip-Chip Direct Bonding. Dziedzic A, Jasinski P, Hrsg. in EMPC 2017 - 21st European Microelectronics and Packaging Conference and Exhibition. IEEE. S. 1-4. doi.org/doi: 10.23919/EMPC.2017.8346897

    Edelmann B, Gupta N, Schnoeder TM, Oelschlegel AM, Shahzad K, Goldschmidt J, Philipsen L, Weinert S, Ghosh A, Saalfeld FC, Nimmagadda SC, Müller P, Braun-Dullaeus R, Mohr J, Wolleschak D, Kliche S, Amthauer H, Heidel FH, Schraven B, Isermann B, Müller AJ, Fischer T. 2018. JAK2-V617F promotes venous thrombosis through β1/β2 integrin activation. Journal of Clinical Investigation. 128(10):4359-4371. https://doi.org/10.1172/JCI90312

    Henschke JU, Oelschlegel AM, Angenstein F, Ohl FW, Goldschmidt J, Kanold PO, Budinger E. 2018. Early sensory experience influences the development of multisensory thalamocortical and intracortical connections of primary sensory cortices. Brain Structure and Function. 223(3):1165-1190. https://doi.org/10.1007/s00429-017-1549-1

    Henschke JU, Ohl FW, Budinger E. 2018. Crossmodal connections of primary sensory cortices largely vanish during normal aging. Frontiers in Aging Neuroscience. 10(MAR). https://doi.org/10.3389/fnagi.2018.00052

    Lippert MT, Takagaki K, Weidner T, Brocka M, Tegtmeier J, Ohl FW. 2018. Optogenetic Intracranial Self-Stimulation as a Method to Study the Plasticity-Inducing Effects of Dopamine. Manahan-Vaughan D, editor. In Handbook of in Vivo Neural Plasticity Techniques. Elsevier. pp. 311-326. (Handbook of Behavioral Neuroscience). https://doi.org/10.1016/B978-0-12-812028-6.00017-3

    Peterson AJ, Heil P. 2018. A simple model of the inner-hair-cell ribbon synapse accounts for mammalian auditory-nerve-fiber spontaneous spike times. Hearing Research. 363:1-27. https://doi.org/10.1016/j.heares.2017.09.005

    Peterson AJ, Huet A, Bourien J, Puel JL, Heil P. 2018. Recovery of auditory-nerve-fiber spike amplitude under natural excitation conditions. Hearing Research. 370:248-263. https://doi.org/10.1016/j.heares.2018.08.007

    Schulz AL, Woldeit ML, Ohl FW. 2017. Neurobiological fundamentals of strategy change: A core competence of companion-systems. Biundo S, Wendemuth A, editors. In Cognitive Technologies: A Paradigm Shift in Human-Technology Interaction. Springer Verlag. pp. 145-166. (Cognitive Technologies). https://doi.org/10.1007/978-3-319-43665-4_8

    Tegtmeier J, Brosch M, Janitzky K, Heinze H-J, Ohl FW*, Lippert MT*. 2018. CAVE: An Open-Source Tool for Combined Analysis of Head-Mounted Calcium Imaging and Behavior in MATLAB. Frontiers in Neuroscience. 12. https://doi.org/10.3389/fnins.2018.00958   

    Vollmer M. 2018. Neural processing of acoustic and electric interaural time differences in normal-hearing gerbils. Journal of Neuroscience. 38(31):6949-6966. https://doi.org/10.1523/JNEUROSCI.3328-17.2018

     

    2017

    Diepenbrock JP, Jeschke M, Ohl FW, Verhey JL. 2017. Comodulation masking release in the inferior colliculus by combined signal enhancement and masker reduction. Journal of Neurophysiology. 117(2):853-867. https://doi.org/10.1152/jn.00191.2016

    Friedrich B, Heil P. 2017. Onset-duration matching of acoustic stimuli revisited: Conventional arithmetic vs. proposed geometric measures of accuracy and precision. Frontiers in Psychology. 7(JAN). https://doi.org/10.3389/fpsyg.2016.02013

    Happel MFK, Ohl FW. 2017. Compensating level-dependent frequency representation in auditory cortex by synaptic integration of corticocortical input. PLoS ONE. 12(1). https://doi.org/10.1371/journal.pone.0169461

    Heil P, Matysiak A, Neubauer H. 2017. A probabilistic Poisson-based model accounts for an extensive set of absolute auditory threshold measurements. Hearing Research. 353:135-161. https://doi.org/10.1016/j.heares.2017.06.011

    Heil P, Peterson AJ. 2017. Spike timing in auditory-nerve fibers during spontaneous activity and phase locking. Synapse. 71(1):5-36. https://doi.org/10.1002/syn.21925

    Homma NY, Happel MFK, Nodal FR, Ohl FW, King AJ, Bajo VM. 2017. A role for auditory corticothalamic feedback in the perception of complex sounds. Journal of Neuroscience. 37(25):6149-6161. https://doi.org/10.1523/JNEUROSCI.0397-17.2017

    Michels B, Saumweber T, Biernacki R, Thum J, Glasgow RDV, Schleyer M, Chen YC, Eschbach C, Stocker RF, Toshima N, Tanimura T, Louis M, Arias-Gil G, Marescotti M, Benfenati F, Gerber B. 2017. Pavlovian conditioning of larval Drosophila: An illustrated, multilingual, hands-on manual for odor-taste associative learning in maggots. Frontiers in Behavioral Neuroscience. 11. https://doi.org/10.3389/fnbeh.2017.00045

    Scherf T, Angenstein F. 2017. Hippocampal CA3 activation alleviates fMRI-BOLD responses in the rat prefrontal cortex induced by electrical VTA stimulation. PLoS ONE. 12(2). https://doi.org/10.1371/journal.pone.0172926

    Schulz AL, Woldeit ML, Ohl FW. 2017. Neurobiological fundamentals of strategy change: A core competence of companion-systems. Biundo S, Wendemuth A, editors. In Cognitive Technologies: A Paradigm Shift in Human-Technology Interaction. Springer Verlag. pp. 145-166. (Cognitive Technologies). https://doi.org/10.1007/978-3-319-43665-4_8

    Takagaki K, Ohl F. 2017. Complexity and Synergetics: Coarse-graining to investigate cerebral cortex dynamics: The case for experimental simplification of biological phenomena. Müller SC, Plath PJ, Radons G, Fuchs A, editors. In Complexity and Synergetics. 1 ed. Springer. pp. 289 - 299. https://doi.org/10.1007/978-3-319-64334-2

    Töpperwien M, Krenkel M, Vincenz D, Stöber F, Oelschlegel AM, Goldschmidt J*, Salditt T*. 2017. Three-dimensional mouse brain cytoarchitecture revealed by laboratory-based x-ray phase-contrast tomography. Scientific Reports. 7. https://doi.org/10.1038/srep42847                     *equal contribution

    Vincenz D, Wernecke KEA, Fendt M, Goldschmidt J. 2017. Habenula and interpeduncular nucleus differentially modulate predator odor-induced innate fear behavior in rats. Behavioural Brain Research. 332:164-171. https://doi.org/10.1016/j.bbr.2017.05.053

     

    2016

    Arias-Gil G, Ohl FW, Takagaki K, Lippert MT. 2016. Measurement, modeling, and prediction of temperature rise due to optogenetic brain stimulation. Neurophotonics. 3(4). https://doi.org/10.1117/1.NPh.3.4.045007

    Deckert M, Lippert M, Takagaki K, Brose A, Ohl F, Schmidt B. 2016. Fabrication of MEMS-based 3DµECoG-MEAs. Current Directions in Biomedical Engineering. 2(1):83-86. https://doi.org/10.1515/cdbme-2016-0021

    Frischknecht R, Happel MFK. 2016. Einfluss der Extrazellulären Matrix auf plastische Prozesse in jungen und alten Gehirnen: Extrazelluläre Matrix und Hirnplastizität. Neuroforum. 22(1):1-9. https://doi.org/10.1007/S12269-015-0033-1

    Górska U, Gociewicz K, Koculak M, Jurasińska A, Brocka M, Binder M. 2016. Zaburzenia świadomości z perspektywy neuroobrazowania. Aktualnosci Neurologiczne. 16(1):37-49. https://doi.org/10.15557/AN.2016.0006

    Happel MFK. 2016. Dopaminergic impact on local and global cortical circuit processing during learning. Behavioural Brain Research. 299:32-41. https://doi.org/10.1016/j.bbr.2015.11.016

    Helbing C, Brocka M, Scherf T, Lippert MT, Angenstein F. 2016. The role of the mesolimbic dopamine system in the formation of blood-oxygen-level dependent responses in the medial prefrontal/anterior cingulate cortex during high-frequency stimulation of the rat perforant pathway. Journal of Cerebral Blood Flow and Metabolism. 36(12):2177-2193. https://doi.org/10.1177/0271678X15615535

    Homma NY, Bajo VM, Happel MFK, Nodal FR, King AJ. 2016. Mistuning detection performance of ferrets in a go/no-go task. Journal of the Acoustical Society of America. 139(6):EL246-EL251. https://doi.org/10.1121/1.4954378

    Huang Y, Matysiak A, Heil P, König R, Brosch M. 2016. Persistent neural activity in auditory cortex is related to auditory working memory in humans and nonhuman primates. eLife. 5(JULY). https://doi.org/10.7554/eLife.15441

    Jarvers C, Brosch T, Brechmann A, Woldeit ML, Schulz AL, Ohl FW, Lommerzheim M, Neumann H. 2016. Reversal learning in humans and gerbils: Dynamic control network facilitates learning. Frontiers in Neuroscience. 10(NOV). https://doi.org/10.3389/fnins.2016.00535

    Kähne T, Richter S, Kolodziej A, Smalla KH, Pielot R, Engler A, Ohl FW, Dieterich DC, Seidenbecher C, Tischmeyer W, Naumann M, Gundelfinger ED. 2016. Proteome rearrangements after auditory learning: high-resolution profiling of synapse-enriched protein fractions from mouse brain. Journal of Neurochemistry. 138(1):124-138. https://doi.org/10.1111/jnc.13636

    Ohl FW. 2016. On the creation of meaning in the brain-cortical neurodynamics during category learning. In Studies in Systems, Decision and Control. Springer International Publishing. pp. 147-159. (Studies in Systems, Decision and Control). https://doi.org/10.1007/978-3-319-24406-8_14

    Schulz AL, Woldeit ML, Gonçalves AI, Saldeitis K, Ohl FW. 2016. Selective Increase of Auditory Cortico-Striatal Coherence during Auditory-Cued Go/NoGo Discrimination Learning. Frontiers in Behavioral Neuroscience. 9:368. https://doi.org/10.3389/fnbeh.2015.00368

    Spilker C*, Nullmeier S*, Grochowska KM*, Schumacher A, Butnaru I, Macharadze T, Gomes GM, YuanXiang P, Bayraktar G, Rodenstein C, Geiseler C, Kolodziej A, Lopez-Rojas J, Montag D, Angenstein F, Bär J, D’Hanis W, Roskoden T, Mikhaylova M, Budinger E, Ohl FW, Stork O, Zenclussen AC, Karpova A, Schwegler H, Kreutz MR. 2016. A Jacob/Nsmf Gene Knockout Results in Hippocampal Dysplasia and Impaired BDNF Signaling in Dendritogenesis. PLoS Genetics. 12(3). https://doi.org/10.1371/journal.pgen.1005907                       *equal contribution

    Takagaki K, Morales MK, Vitantonio D, Berkowitz F, Bell WL, Kumar PN, Motamedi GK. 2016. Periodic Lateralized Epileptiform Discharges (PLEDs) in Patients with Neurosyphilis and HIV Infection. Clinical EEG and Neuroscience. 47(3):247-250. https://doi.org/10.1177/1550059414552704

     

    2015

    Budinger E, Brechmann A, Brosch M, Heil P, König R, Ohl FW, Scheich H. 2015. Auditory cortex 2014 - towards a synthesis of human and animal research. European Journal of Neuroscience. 41(5):515-517. doi.org/10.1111/ejn.12832

    Deike S, Heil P, Böckmann-Barthel M, Brechmann A. 2015. Decision making and ambiguity in auditory stream segregation. Frontiers in Neuroscience. 9(JUL). https://doi.org/10.3389/fnins.2015.00266

    Happel MFK, Deliano M, Ohl FW. 2015. Combined shuttle-box training with electrophysiological cortex recording and stimulation as a tool to study perception and learning. Journal of Visualized Experiments. 2015(105). https://doi.org/10.3791/53002

    Heil P, Peterson AJ. 2015. Basic response properties of auditory nerve fibers: a review. Cell and Tissue Research. 361(1):129-158. https://doi.org/10.1007/s00441-015-2177-9

    Ilango A, Lobo MK. 2015. Shining light on motivation, emotion, and memory processes. Frontiers in Behavioral Neuroscience. 9(JAN):1-3. https://doi.org/10.3389/fnbeh.2015.00001

    Janitzky K, Lippert MT, Engelhorn A, Tegtmeier J, Goldschmidt J, Heinze HJ, Ohl FW. 2015. Optogenetic silencing of locus coeruleus activity in mice impairs cognitive flexibility in an attentional set-shifting task. Frontiers in Behavioral Neuroscience. 9(NOVEMBER). https://doi.org/10.3389/fnbeh.2015.00286

    König R, Matysiak A, Kordecki W, Sieluzycki C, Zacharias N, Heil P. 2015. Averaging auditory evoked magnetoencephalographic and electroencephalographic responses: A critical discussion. European Journal of Neuroscience. 41(5):631-640. https://doi.org/10.1111/ejn.12833

    Meyer AF, Diepenbrock JP, Ohl FW, Anemüller J. 2015. Fast and robust estimation of spectro-temporal receptive fields using stochastic approximations. Journal of Neuroscience Methods. 246:119-133. https://doi.org/10.1016/j.jneumeth.2015.02.009

    Mylius J, Happel MFK, Gorkin AG, Huang Y, Scheich H, Brosch M. 2015. Fast transmission from the dopaminergic ventral midbrain to the sensory cortex of awake primates. Brain Structure and Function. 220(6):3273-3294. https://doi.org/10.1007/s00429-014-0855-0

    Oelschlegel AM, Geissen M, Lenk M, Riebe R, Angermann M, Schaetzl H, Groschup MH. 2015. A bovine cell line that can be infected by natural sheep scrapie prions. PLoS ONE. 10(1):e0117154. https://doi.org/10.1371/journal.pone.0117154

    Ohl FW. 2015. Role of cortical neurodynamics for understanding the neural basis of motivated behavior - lessons from auditory category learning. Current Opinion in Neurobiology. 31:88-94. doi.org/10.1016/j.conb.2014.08.014

    Scherf T, Angenstein F. 2015. Postsynaptic and spiking activity of pyramidal cells, the principal neurons in the rat hippocampal CA1 region, does not control the resultant BOLD response: A combined electrophysiologic and fMRI approach. Journal of Cerebral Blood Flow and Metabolism. 35(4):565-575. https://doi.org/10.1038/jcbfm.2014.252

    Takagaki K, Russell J, Lippert MT, Motamedi GK. 2015. Development of the posterior basic rhythm in children with autism. Clinical Neurophysiology. 126(2):297-303. https://doi.org/10.1016/j.clinph.2014.04.022

    Tziridis K, Ahlf S, Jeschke M, Happel MFK, Ohl FW, Schulze H. 2015. Noise trauma induced neural plasticity throughout the auditory system of Mongolian gerbils: Differences between tinnitus developing and non-developing animals. Frontiers in Neurology. 6:22. https://doi.org/10.3389/fneur.2015.00022

    Vitantonio D, Xu W, Geng X, Wolff BS, Takagaki K, Motamedi GK, Wu JY. 2015. Emergence of dominant initiation sites for interictal spikes in rat neocortex. Journal of Neurophysiology. 114(6):3315-3325. https://doi.org/10.1152/jn.00471.2014

    Wanger T, Wetzel W, Scheich H, Ohl FW, Goldschmidt J. 2015. Spatial patterns of neuronal activity in rat cerebral cortex during non-rapid eye movement sleep. Brain Structure and Function. 220(6):3469-3484. https://doi.org/10.1007/s00429-014-0867-9

    Wernecke KEA, Vincenz D, Storsberg S, D'Hanis W, Goldschmidt J, Fendt M. 2015. Fox urine exposure induces avoidance behavior in rats and activates the amygdalar olfactory cortex. Behavioural Brain Research. 279:76-81. https://doi.org/10.1016/j.bbr.2014.11.020

    Woldeit M, Schulz AL, Brosch M,Wanger T,Ohl F. 2015. Superordinate strategy use of Mongolian gerbils during an auditory serial reversal task. in Proceedings of the 1st International Symposium on Companion-Technology (ISCT 2015) - September 23rd-25th, Ulm University, Germany.

     

    2014

    Górska U, Koculak M, Brocka M, Binder M. 2014. Zaburzenia s̈wiadomos̈ci - Perspektywa kliniczna i etyczna. Aktualnosci Neurologiczne. 14(3):190-198. https://doi.org/10.15557/AN.2014.0022

    Happel MFK, Deliano M, Handschuh J, Ohl FW. 2014. Dopamine-modulated recurrent corticoefferent feedback in primary sensory cortex promotes detection of behaviorally relevant stimuli. Journal of Neuroscience. 34(4):1234-1247. https://doi.org/10.1523/JNEUROSCI.1990-13.2014

    Happel MFK, Niekisch H, Castiblanco Rivera LL, Ohl FW, Deliano M, Frischknecht R. 2014. Enhanced cognitive flexibility in reversal learning induced by removal of the extracellular matrix in auditory cortex. Proceedings of the National Academy of Sciences of the United States of America. 111(7):2800-2805. https://doi.org/10.1073/pnas.1310272111

    Heil P. 2014. Towards a unifying basis of auditory thresholds: Binaural summation. JARO - Journal of the Association for Research in Otolaryngology. 15(2):219-234. doi.org/10.1007/s10162-013-0432-x

    Kolodziej A, Lippert M, Angenstein F, Neubert J, Pethe A, Grosser OS, Amthauer H, Schroeder UH, Reymann KG, Scheich H, Ohl FW, Goldschmidt J. 2014. SPECT-imaging of activity-dependent changes in regional cerebral blood flow induced by electrical and optogenetic self-stimulation in mice. NeuroImage. 103:171-180. https://doi.org/10.1016/j.neuroimage.2014.09.023

    Lison H, Happel MFK, Schneider F, Baldauf K, Kerbstat S, Seelbinder B, Schneeberg J, Zappe M, Goldschmidt J, Budinger E, Schröder UH, Ohl FW, Schilling S, Demuth HU, Scheich H, Reymann KG, Rönicke R. 2014. Disrupted cross-laminar cortical processing in β amyloid pathology precedes cell death. Neurobiology of Disease. 63:62-73. https://doi.org/10.1016/j.nbd.2013.11.014

    Meyer AF, Diepenbrock JP, Happel MFK, Ohl FW, Anemüller J. 2014. Discriminative learning of receptive fields from responses to non-gaussian stimulus ensembles. PLoS ONE. 9(4). https://doi.org/10.1371/journal.pone.0093062

    Meyer AF, Diepenbrock JP, Ohl FW, Anemüller J. 2014. Temporal variability of spectro-temporal receptive fields in the anesthetized auditory cortex. Frontiers in Computational Neuroscience. 8(DEC). https://doi.org/10.3389/fncom.2014.00165

    Michael Ilango A, Shumake J, Wetzel W, Ohl FW. 2014. Contribution of emotional and motivational neurocircuitry to cue-signaled active avoidance learning. Frontiers in Behavioral Neuroscience. 8(October). https://doi.org/10.3389/fnbeh.2014.00372

    Peterson AJ, Irvine DRF, Heil P. 2014. A model of synaptic vesicle-pool depletion and replenishment can account for the interspike interval distributions and nonrenewal properties of spontaneous spike trains of auditory-nerve fibers. Journal of Neuroscience. 34(45):15097-15109. https://doi.org/10.1523/JNEUROSCI.0903-14.2014

    Saldeitis K, Happel MFK, Ohl FW, Scheich H, Budinger E. 2014. Anatomy of the auditory thalamocortical system in the mongolian gerbil: Nuclear origins and cortical field-, layer-, and frequency-specificities. Journal of Comparative Neurology. 522(10):2397-2430. https://doi.org/10.1002/cne.23540

     

    2013

    Heil P, Neubauer H, Tetschke M, Irvine DRF. 2013. A probabilistic model of absolute auditory thresholds and its possible physiological basis. In Advances in Experimental Medicine and Biology. pp. 21-29. (Advances in experimental medicine and biology). https://doi.org/10.1007/978-1-4614-1590-9_3

    Heil P, Verhey JL, Zoefel B. 2013. Modelling detection thresholds for sounds repeated at different delays. Hearing Research. 296:83-95. https://doi.org/10.1016/j.heares.2012.12.002

    Ilango A, Shumake J, Wetzel W, Scheich H, Ohl FW. 2013. Electrical Stimulation of Lateral Habenula during Learning: Frequency-Dependent Effects on Acquisition but Not Retrieval of a Two-Way Active Avoidance Response. PLoS ONE. 8(6). https://doi.org/10.1371/journal.pone.0065684

    Keating P, Nodal FR, Gananandan K, Schulz AL, King AJ. 2013. Behavioral sensitivity to broadband binaural localization cues in the ferret. JARO - Journal of the Association for Research in Otolaryngology. 14(4):561-572. https://doi.org/10.1007/s10162-013-0390-3

    Lippert MT, Takagaki K, Kayser C, Ohl FW. 2013. Asymmetric Multisensory Interactions of Visual and Somatosensory Responses in a Region of the Rat Parietal Cortex. PLoS ONE. 8(5):e63631. https://doi.org/10.1371/journal.pone.0063631

    Matysiak A, Kordecki W, Sieluzycki C, Zacharias N, Heil P, König R. 2013. Variance stabilization for computing and comparing grand mean waveforms in MEG and EEG. Psychophysiology. 50(7):627-639. https://doi.org/10.1111/psyp.12047

    Meyer AF, Diepenbrock JP, Ohl FW, Anemuller J. 2013. Quantifying neural coding noise in linear threshold models. In International IEEE/EMBS Conference on Neural Engineering. pp. 1127-1130. https://doi.org/10.1109/NER.2013.6696136

    Pohl NU, Slabbekoorn H, Neubauer H, Heil P, Klump GM, Langemann U. 2013. Why longer song elements are easier to detect: Threshold level-duration functions in the Great Tit and comparison with human data. Journal of Comparative Physiology A: Neuroethology, Sensory, Neural, and Behavioral Physiology. 199(3):239-252. https://doi.org/10.1007/s00359-012-0789-z

    Traue HC, Ohl F, Schwenker F, Kessler H, Limbrecht K, Hoffmann H, Scherer S, Kotzyba M, Scheck A, Walter S. 2013. A Framework for Emotions and Dispositions in Man-Companion Interaction. In Coverbal Synchrony in Human-Machine Interaction. CRC Press. pp. 99-140.

    Tyll S, Bonath B, Schoenfeld MA, Heinze HJ, Ohl FW, Noesselt T. 2013. Neural basis of multisensory looming signals. NeuroImage. 65:13-22. https://doi.org/10.1016/j.neuroimage.2012.09.056

    Wanger T, Takagaki K, Lippert MT, Goldschmidt J, Ohl FW. 2013. Wave propagation of cortical population activity under urethane anesthesia is state dependent. Neuroscience. 14. https://doi.org/10.1186/1471-2202-14-78

    Zoefel B, Heil P. 2013. Detection of near-threshold sounds is independent of eeg phase in common frequency bands. Frontiers in Psychology. 4(MAY). https://doi.org/10.3389/fpsyg.2013.00262

     

    2012

    Anemüller J, Caputo B, Hermansky H, Ohl FW, Pajdla T, Pavel M, Van Gool L, Vogels R, Wabnik S, Weinshall D. 2012. DIRAC: Detection and identification of rare audio-visual events. In Detection and Identification of Rare Audiovisual Cues. Springer Nature. pp. 3-35. (Studies in Computational Intelligence). Available from: 10.1007/978-3-642-24034-8_1

    Apostolova I, Wunder A, Dirnagl U, Michel R, Stemmer N, Lukas M, Derlin T, Gregor-Mamoudou B, Goldschmidt J, Brenner W, Buchert R. 2012. Brain perfusion SPECT in the mouse: Normal pattern according to gender and age. NeuroImage. 63(4):1807-1817. Available from: 10.1016/j.neuroimage.2012.08.038

    Budinger E, Heil P. 2012. Anatomy of the auditory cortex. In Listening to Speech: An Auditory Perspective. Taylor and Francis. pp. 91-113. Available from: 10.4324/9780203933107

    Deike S, Heil P, Böckmann-Barthel M, Brechmann A. 2012. The build-up of auditory stream segregation: A different perspective. Frontiers in Psychology. 3(OCT). Available from: 10.3389/fpsyg.2012.00461

    Fillbrandt A, Ohl FW. 2012. Modulations of single-trial interactions between the auditory and the visual cortex during prolonged exposure to audiovisual stimuli with fixed stimulus onset asynchrony. In Detection and Identification of Rare Audiovisual Cues. Springer Nature. pp. 155-180. (Studies in Computational Intelligence). Available from: 10.1007/978-3-642-24034-8_13

    Gao X, Xu W, Wang Z, Takagaki K, Li B, Wu JY. 2012. Interactions between two propagating waves in rat visual cortex. Neuroscience. 216:57-69. Available from: 10.1016/j.neuroscience.2012.04.062

    Haroon F, Händel U, Angenstein F, Goldschmidt J, Kreutzmann P, Lison H, Fischer KD, Scheich H, Wetzel W, Schlüter D, Budinger E. 2012. Toxoplasma gondii actively inhibits neuronal function in chronically infected mice. PLoS ONE. 7(4). Available from: 10.1371/journal.pone.0035516

    Ilango A, Shumake J, Wetzel W, Scheich H,Ohl FW. 2012. The role of dopamine in the context of aversive stimuli with particular reference to acoustically signaled avoidance learning. Frontiers in Neuroscience. (SEP). Available from: 10.3389/fnins.2012.00132

    Kähne T, Kolodziej A, Smalla KH, Eisenschmidt E, Haus UU, Weismantel R, Kropf S, Wetzel W, Ohl FW, Tischmeyer W, Naumann M, Gundelfinger ED. 2012. Synaptic proteome changes in mouse brain regions upon auditory discrimination learning. Proteomics. 12(15-16):2433-2444. Available from: 10.1002/pmic.201100669

    Lovell J, Brosch M, Budinger E, Goldschmidt J, Scheich H, Tschorn S, Wendt B, Zuschratter W. 2012. Scanning and Transmission Electron Microscope Examination of Cochlea Hair and Pillar Cells from the Ear of the Mongolian Gerbil (Meriones unguiculatus). Anatomy and Physiology. 2(3).

    Macharadze T, Pielot R, Wanger T, Scheich H, Gundelfinger ED, Budinger E, Goldschmidt J, Kreutz MR. 2012. Altered neuronal activity patterns in the visual cortex of the adult rat after partial optic nerve crush-a single-cell resolution metabolic mapping study. Cerebral Cortex. 22(8):1824-1833. Available from: 10.1093/cercor/bhr256

    Schreiber S, Bueche CZ, Garz C, Kropf S, Angenstein F, Goldschmidt J, Neumann J, Heinze HJ, Goertler M, Reymann KG, Braun H. 2012. The pathologic cascade of cerebrovascular lesions in SHRSP: Is erythrocyte accumulation an early phase. Journal of Cerebral Blood Flow and Metabolism. 32(2):278-290. Available from: 10.1038/jcbfm.2011.122

    Wanger T, Scheich H, Ohl FW, Goldschmidt J. 2012. The use of thallium diethyldithiocarbamate for mapping CNS potassium metabolism and neuronal activity: Tl +-redistribution, Tl +-kinetics and Tl +-equilibrium distribution. Journal of Neurochemistry. 122(1):106-114. Available from: 10.1111/j.1471-4159.2012.07757.x

    Weinshall D, Zweig A, Hermansky H, Kombrink S, Ohl FW, Anemüller J, Bach JH, Van Gool L, Nater F, Pajdla T, Havlena M, Pavel M. 2012. Beyond novelty detection: Incongruent events, when general and specific classifiers disagree. IEEE Transactions on Pattern Analysis and Machine Intelligence. 34(10):1886-1901. Available from: 10.1109/TPAMI.2011.279

    Woldeit ML, Schulz AL, Ohl FW. 2012. Phase de-synchronization effects auditory gating in the ventral striatum but not auditory cortex. Neuroscience. 216:70-81. Available from: 10.1016/j.neuroscience.2012.04.058

    Zacharias N, König R, Heil P. 2012. Stimulation-history effects on the M100 revealed by its differential dependence on the stimulus onset interval. Psychophysiology. 49(7):909-919. Available from: 10.1111/j.1469-8986.2012.01370.x

     

    2011

    Brechmann A, Brosch M, Budinger E, Heil P, König R, Ohl F, Scheich H. 2011. Auditory cortex - Current concepts in human and animal research. Hearing Research. 271(1-2):1-2. Available from: 10.1016/j.heares.2010.10.016

    Coomber B, Edwards D, Jones SJ, Shackleton TM, Goldschmidt J, Wallace MN, Palmer AR. 2011. Cortical inactivation by cooling in small animals. Frontiers in Systems Neuroscience. 5(JUNE 2011):53. Available from: 10.3389/fnsys.2011.00053

    Heidt T, Deininger F, Peter K, Goldschmidt J, Pethe A, Hagemeyer CE, Neudorfer I, Zirlik A, Weber WA, Bode C, Meyer PT, Behe M, von zur Mühlen C. 2011. Activated platelets in carotid artery thrombosis in mice can be selectively targeted with a radiolabeled single-chain antibody. PLoS ONE. 6(3). Available from: 10.1371/journal.pone.0018446

    Heil P, Neubauer H, Irvine DRF. 2011. An improved model for the rate-level functions of auditory-nerve fibers. Journal of Neuroscience. 31(43):15424-15437. Available from: 10.1523/JNEUROSCI.1638-11.2011

    Ilango A, Shumake J, Wetzel W, Scheich H,Ohl FW. 2011. Effects of ventral tegmental area stimulation on the acquisition and long-term retention of active avoidance learning. Behavioural Brain Research. 225(2):515-521. Available from: 10.1016/j.bbr.2011.08.014

    Scheich H, Brechmann A, Brosch M, Budinger E, Ohl FW, Selezneva E, Stark H, Tischmeyer W, Wetzel W. 2011. Behavioral semantics of learning and crossmodal processing in auditory cortex: The semantic processor concept. Hearing Research. 271(1-2):3-15. Available from: 10.1016/j.heares.2010.10.006

    Scheich H, Ohl F. 2011. Direkter Zugang zum Gehirn. Spektrum der Wissenschaft.

    Scheich H,Ohl FW. 2011. A semantic concept of auditory cortex function and learning. In The Auditory Cortex. Springer. pp. 369-387. Available from: 10.1007/978-1-4419-0074-6_17

    Takagaki K, Perito ER, Jose FA, Heyman MB. 2011. Gastric mucosal damage from ingestion of 3 button cell batteries. Journal of Pediatric Gastroenterology and Nutrition. 53(2):222-223. Available from: 10.1097/MPG.0b013e3182107ba1

    Takagaki K, Zhang C, Wu JY, Ohl FW. 2011. Flow detection of propagating waves with temporospatial correlation of activity. Journal of Neuroscience Methods. 200(2):207-218. Available from: 10.1016/j.jneumeth.2011.05.023

    Tyll S, Budinger E, Noesselt T. 2011. Thalamic influences on multisensory integration. Communicative and Integrative Biology. 4(4):378-381.

    Zacharias N, Sieluzycki C, Kordecki W, König R, Heil P. 2011. The M100 component of evoked magnetic fields differs by scaling factors: Implications for signal averaging. Psychophysiology. 48(8):1069-1082. Available from: 10.1111/j.1469-8986.2011.01183.x

     

    2010

    Goldschmidt J, Wanger T, Engelhorn A, Friedrich H, Happel M, Ilango A, Engelmann M, Stuermer IW, Ohl FW, Scheich H. 2010. High-resolution mapping of neuronal activity using the lipophilic thallium chelate complex TlDDC: Protocol and validation of the method. NeuroImage. 49(1):303-315. Available from: 10.1016/j.neuroimage.2009.08.012

    Hammer R, Brechmann A, Ohl F, Weinshall D, Hochstein S. 2010. Differential category learning processes: The neural basis of comparison-based learning and induction. NeuroImage. 52(2):699-709. Available from: 10.1016/j.neuroimage.2010.03.080

    Happel MFK, Jeschke M,Ohl FW. 2010. Spectral integration in primary auditory cortex attributable to temporally precise convergence of thalamocortical and intracortical input. Journal of Neuroscience. 30(33):11114-11127. Available from: 10.1523/JNEUROSCI.0689-10.2010

    Heil P, Neubauer H, Irvine DRF. 2010. A new model for the shapes of rate-level functions of auditory-nerve fibers. In Proceedings of the 20th International Congress on Acoustics. pp. 3156-3163.

    Heil P, Neubauer H. 2010. Summing across different active zones can explain the quasi-linear Ca 2+-dependencies of exocytosis by receptor cells. Frontiers in Synaptic Neuroscience. 2 Article 148(NOV):1-15. Available from: 10.3389/fnsyn.2010.00148

    Ilango A, Wetzel W, Scheich H,Ohl FW. 2010. The combination of appetitive and aversive reinforcers and the nature of their interaction during auditory learning. Neuroscience. 166(3):752-762. Available from: 10.1016/j.neuroscience.2010.01.010

    Lippert MT, Steudel T, Ohl FW, Logothetis NK, Kayser C. 2010. Coupling of neural activity and fMRI-BOLD in the motion area MT. Magnetic Resonance Imaging. 28(8):1087-1094. Available from: 10.1016/j.mri.2009.12.028

    Moeller CK, Kurt S, Happel MFK, Schulze H. 2010. Long-range effects of GABAergic inhibition in gerbil primary auditory cortex. European Journal of Neuroscience. 31(1):49-59. Available from: 10.1111/j.1460-9568.2009.07039.x

    Noesselt T, Tyll S, Boehler CN, Budinger E, Heinze HJ, Driver J. 2010. Sound-induced enhancement of low-intensity vision: Multisensory influences on human sensory-specific cortices and thalamic bodies relate to perceptual enhancement of visual detection sensitivity. Journal of Neuroscience. 30(41):13609-13623. Available from: 10.1523/JNEUROSCI.4524-09.2010

    Shumake J, Ilango A, Scheich H, Wetzel W, Ohl FW. 2010. Differential neuromodulation of acquisition and retrieval of avoidance learning by the lateral habenula and ventral tegmental area. Journal of Neuroscience. 30(17):5876-5883. Available from: 10.1523/JNEUROSCI.3604-09.2010

    Woldeit ML, Korz V. 2010. Theta oscillations during holeboard training in rats: different learning strategies entail different context-dependent modulations in the hippocampus. Neuroscience. 165(3):642-653. Available from: 10.1016/j.neuroscience.2009.11.002

    Zacharias N, Sieluzycki C, Matysiak MA, König R, Heil P. 2010. Relevant observations for averaging stimulus evoked magnetic fields across trials and across subjects. In 17th International Conference on Biomagnetism Advances in Biomagnetism. pp. 179-182. Available from: 10.1007/978-3-642-12197-5_39

    Zaehle T, Lenz D, Ohl FW, Herrmann CS. 2010. Resonance phenomena in the human auditory cortex: Individual resonance frequencies of the cerebral cortex determine electrophysiological responses. Experimental Brain Research. 203(3):629-635. Available from: 10.1007/s00221-010-2265-8

     

     

  • Lehre & Praktika

    Lehre & Praktika

    Unsere Abteilung ist aktiv in die Ausbildung von Studierenden der Otto-von-Guericke-Universität Magdeburg eingebunden.

    Mitglieder unserer Abteilung unterrichten im Masterstudiengang "Integrative Neuroscience" und im Bachelorstudiengang "Philosophie, Neurowissenschaften, Kognition". Wir beteiligen uns an mehreren Vorlesungsreihen und richten zu dem den systemphysiologischen Teil des neurowissenschaftlichen Grundpraktikums aus.

    Im Rahmen von Block-Praktika, Lab rotations und Assistenzprojekten ermöglichen wir Studierenden in unterschiedlichsten Phasen ihrer Ausbildung Einblicke in die praktische Forschungstätigkeit in einem interdisziplinären internationalen Forschungsteam. Wenn Sie Interesse an unserem Forschungsgebiet haben, schreiben Sie uns oder rufen Sie an.

  • Hugo-Junkers-Preis

    Hugo-Junkers-Preis


    Datenschutz | Impressum

    Teambild der Hugo-Junkers-Preisträger 2017 mit Urkunde
    Prof. Dr. Armin Dadgar und Martin Deckert (beide OVGU) sowie Dr. Michael Lippert und Prof. Dr. Frank Ohl (beide LIN) (v.l.n.r.) belegten in der Kategorie „Innovativste Vorhaben der Grundlagenforschung“ den 1. Platz. Mit ihrer entwickelten LED-Elektrode CortiGrid können die Wissenschaftler über optogenetische Verfahren sensorische Bereiche im Gehirn ansteuern (Foto: LIN/Anika Dirks).

    Mitglieder der Abteilung (Michael Lippert und Frank Ohl) haben zusammen mit ihren Kollegen der Otto-von-Guericke-Universität (Bertram Schmidt, Armin Dadgar und Martin Deckert) den ersten Platz des Hugo-Junkers-Preises 2017 in der Kategorie "Innovativste Vorhaben der Grundlagenforschung" erhalten.

    Unser Projekt "CortiGrid" erlaubt die gleichzeitige optogenetische Stimulation von Hirnarealen mit neu entwickelten LEDs während der Messung von elektrophysiologischen Signalen. Diese Innovation ist ein wichtiger Schritt für die Entwicklung sogenannter interaktiver bidirektionaler Neuroprothesen, die nicht nur Informationen aus dem Gehirn auslesen oder versuchen Information in das Gehirn einzuschreiben, sondern einen interaktiven "Dialog" mit dem Gehirn führen.

    Weitere Infos finden Sie in unserer Pressemitteilung.

  • Konferenzen

    Konferenzen

    Teilnehmer der Auditory Cortex Konferenz vor Bergkulisse
    Teilnehmer der Auditory Cortex Konferenz 2017 in Kanada (Foto: Don Lee, The Banff Centre)

    Die Abteilung ist aktiv an der Organisation mehrerer regelmäßiger wissenschaftlicher Konferenzen beteiligt.

    Wir organisieren in Zusammenarbeit mit Kollegen des LIN die regelmäßige International Conference on Auditory Cortex, sowie in Zusammenarbeit mit Kollegen des LIN und der OVGU das International Symposium on Learning and Memory.

    Mitglieder der Abteilung organisieren zudem wissenschaftliche Symposien bei den Tagungen der wissenschaftlichen Gesellschaften, beispielsweise der Deutschen Neurowissenschaftlichen Gesellschaft.

  • Öffentlichkeitsarbeit & Medienberichterstattung

    Öffentlichkeitsarbeit & Medienberichterstattung

    Interview mit Michael Lippert, im Hintergrund kümmern sich 2 Wissenschaftlerinnen, um die beiden Ratten
    Bericht über Basketballspielende Ratten zur Langen Nacht der Wissenschaft 2015

    Forschende unserer Abteilung äußern sich in Medien zu Fragen der neurowissenschaftlichen Forschung (z.B. Neuroprothetik) oder gesellschaftlich relevanten Themen (z.B. Neurowissenschaften und Willensfreiheit).

    Zusammen mit dem damaligen Präsidenten des Oberlandesgerichtes Sachsen-Anhalt, Winfried Schubert, wurde 2015 ein internationales Symposium "Gehirn Freiheit Schuld" in Naumburg durchgeführt.



    Weitere Berichte:

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