LIN Personal

Prof. Dr. Constanze Seidenbecher

Arbeitsgruppenleiterin

Verhaltensneurologie

Leibniz-Institut für Neurobiologie
Brenneckestr. 6
39118 Magdeburg
Deutschland
Telefon: +49 391 6263 92051
E-Mail: Constanze.Seidenbecher@lin-magdeburg.de
ORCID: 0000-0002-7433-2716

Forschungsinteressen
Forschungsinteressen
Wir interessieren uns dafür, wie die Extrazellulärmatrix des Gehirns zur enormen Leistungsfähigkeit und Plastizität dieses Organs beiträgt.
Die Matrix, die immerhin ca. 20-25% des Gewebes ausmacht, wird von Neuronen und Gliazellen gebildet und besteht aus großen Kohlehydrat-Polymeren wie Hyaluronsäure, Proteoglycanen wie Brevican oder Neurocan, und einer Vielzahl von Glycoproteinen. Sie ändert ihre Struktur und Zusammensetzung während der Hirnentwicklung von Mensch und Tier, aber auch bei Hirnschädigungen, neurologischen oder psychiatrischen Erkrankungen und während des natürlichen Alterungsprozesses.
Wir wollen verstehen, wie die Aktivität von Nervenzellen, z.B. beim Lernen oder Erinnern, und die Integrität der Extrazellulärmatrix miteinander wechselwirken. Wir untersuchen daher einerseits, wie sich künstlich herbeigeführte Matrix-Veränderungen, z.B. durch enzymatischen Abbau der Matrix oder in Proteoglycan-Knockout-Mäusen auf Aktivitätseigenschaften der Nervenzellen und kognitive Fähigkeiten der Tiere auswirken, und andererseits suchen wir nach natürlichen Matrix-Veränderungen im ZNS, die durch neuronale Aktivität induziert oder beeinflusst werden können.
Besonders interessiert uns die Rolle von Neuromodulatoren wie Dopamin beim Matrix-Umbau sowie der Zusammenhang von Matrix-Veränderungen und natürlichem Altern oder Epilepsie.
Bei menschlichen Probanden suchen wir nach kleinen Veränderungen in Matrix-kodierenden Genen, sogenannten Einzelnukleotid-Polymorphismen, und deren Assoziation mit kognitiven Fähigkeiten und Flexibilität.
Lebenslauf
Lebenslauf
Constanze Seidenbecher hat von 1983 bis 1988 Biochemie an der Martin-Luther-Universität Halle studiert und 1996 an der Otto-von-Guericke-Universität Magdeburg promoviert. 2005 hat sie sich habilitiert und die Venia legendi für Biochemie an der Medizinischen Fakultät der Otto-von-Guericke-Universität erhalten, wo sie 2015 zur außerplanmäßigen Professorin ernannt wurde. Sie hält Vorlesungen über Neurobiochemie für Studierende der Medizin und unterrichtet im Studiengang Integrative Neuroscience.
Constanze Seidenbecher ist Arbeitsgruppenleiterin der Gruppe "Synapse - Brain - Cognition" gemeinsam mit Björn Schott.
Von 2004 bis 2022 leitete sie auch die Wissenschaftsorganisation und Öffentlichkeitsarbeit am LIN.
Sie leitet seit 2018 die Kommission für Ethik in der sicherheitsrelevanten Forschung am LIN und vertritt seit 2022 die Leibniz-Gemeinschaft im Förderverein "DasGehirn.Info".
Im Center for Behavioral Brain Sciences (CBBS) Magdeburg engagiert sie sich seit dessen Gründung 2007 für den Neurowissenschaftsstandort Magdeburg und gehört seit 2017 dem CBBS-Direktorium an. Sie ist Mitglied im Vorstand des SFB1436 "Neurale Ressourcen der Kognition" und des Graduiertenkollegs SynAGE sowie im Steering Committee des DZPG-Standortes Jena - Magdeburg - Halle "CIRC".
Für die International Society for Neurochemistry (ISN) hat sie als Vorsitzende des School-Ausschusses von 2009 bis 20017 internationale Sommerschulen für Doktoranden und Postdocs in Griechenland, Mexico, Australien und Frankreich organisiert und ist seit 2020 Mitglied des ISN-Council.
Sie ist seit 2015 Handling Editor für Journal of Neurochemistry und Review Editor für Frontiers in Molecular Neuroscience.
Außerdem engagiert sie sich als Mentorin für Nachwuchswissenschaftlerinnen und Nachwuchswissenschaftler.
Publikationen
Publikationen
Khoshneviszadeh M, Henneicke S, Pirici D, Senthilnathan A, Morton L, Arndt P, Kaushik R, Norman O, Jukkola J, Dunay IR, et al. 2024. Microvascular damage, neuroinflammation and extracellular matrix remodeling in Col18a1 knockout mice as a model for early cerebral small vessel disease. Matrix biology : journal of the International Society for Matrix Biology. 128:39-64. https://doi.org/10.1016/j.matbio.2024.02.007
Blondiaux A, Jia S, Annamneedi A, Çalışkan G, Nebel J, Montenegro-Venegas C, Wykes RC, Fejtova A, Walker MC, Stork O, et al. 2023. Linking epileptic phenotypes and neural extracellular matrix remodeling signatures in mouse models of epilepsy. Neurobiology of Disease. 188:Article 106324. https://doi.org/10.1016/j.nbd.2023.106324
Raschick M, Richter A, Fischer L, Knopf L, Schult A, Yakupov R, Behnisch G, Guttek K, Düzel E, Dunay IR, et al. 2023. Plasma concentrations of anti-inflammatory cytokine TGF-β are associated with hippocampal structure related to explicit memory performance in older adults. Journal of Neural Transmission. 130(8):989-1002. https://doi.org/10.1007/s00702-023-02638-1
Richter A, Soch J, Kizilirmak JM, Fischer L, Schütze H, Assmann A, Behnisch G, Feldhoff H, Knopf L, Raschick M, et al. 2023. Single-value scores of memory-related brain activity reflect dissociable neuropsychological and anatomical signatures of neurocognitive aging. Human Brain Mapping. 44(8):3283-3301. https://doi.org/10.1002/hbm.26281
Blondiaux A, Jia S, Annamneedi A, Çalişkan G, Schulze J, Montenegro-Venegas C, Wykes RC, Fejtova A, Walker MC, Stork O, et al. 2023. Neural Extracellular Matrix Remodeling Signatures in Genetic and Acquired Mouse Models of Epilepsy. (bioRxiv). https://doi.org/10.1101/2023.04.19.537468
Höhn L, Hußler W, Richter A, Smalla K-H, Birkl-Toeglhofer A-M, Birkl C, Vielhaber S, Leber SL, Gundelfinger ED, Haybaeck J, et al. 2023. Extracellular Matrix Changes in Subcellular Brain Fractions and Cerebrospinal Fluid of Alzheimer's Disease Patients. International Journal of Molecular Sciences. 24(6):Article 5532. https://doi.org/10.3390/ijms24065532
Malci A, Sandoval R, Gundelfinger ED, Naumann M, Seidenbecher C, Herrera-Molina R. 2022. Ca2+ signaling in postsynaptic neurons: neuroplastin-65 regulates the interplay between plasma membrane Ca2+ ATPases and ionotropic glutamate receptors. Cell calcium. 106:Article 102623. https://doi.org/10.1016/j.ceca.2022.102623
Hußler W, Höhn L, Stolz C, Vielhaber S, Garz C, Schmitt FC, Gundelfinger ED, Schreiber S, Seidenbecher CI. 2022. Brevican and Neurocan Cleavage Products in the Cerebrospinal Fluid - Differential Occurrence in ALS, Epilepsy and Small Vessel Disease. Frontiers in Cellular Neuroscience. 16:Article 838432. https://doi.org/10.3389/fncel.2022.838432
Richter A, Soch J, Kizilirmak JM, Fischer L, Schütze H, Assmann A, Behnisch G, Feldhoff H, Knopf L, Raschick M, et al. 2022. Summary statistics of memory-related fMRI activity reflect dissociable neuropsychological and anatomical signatures of neurocognitive aging. bioRxiv. https://doi.org/10.1101/2022.02.04.479169
Richter A, de Boer L, Guitart-Masip M, Behnisch G, Seidenbecher CI, Schott BH. 2021. Motivational learning biases are differentially modulated by genetic determinants of striatal and prefrontal dopamine function. Journal of Neural Transmission. 128(11):1705-1720. https://doi.org/10.1007/s00702-021-02382-4
Soch J, Richter A, Schütze H, Kizilirmak JM, Assmann A, Behnisch G, Feldhoff H, Fischer L, Heil J, Knopf L, et al. 2021. A comprehensive score reflecting memory-related fMRI activations and deactivations as potential biomarker for neurocognitive aging. Human Brain Mapping. 42(14):4478-4496. https://doi.org/10.1002/hbm.25559
Dityatev A, Seidenbecher C, Morawski M. 2021. Brain extracellular matrix: An upcoming target in neurological and psychiatric disorders. European Journal of Neuroscience. 53(12):3807-3810. https://doi.org/10.1111/ejn.15336
Assmann A, Richter A, Schütze H, Soch J, Barman A, Behnisch G, Knopf L, Raschick M, Schult A, Wüstenberg T, et al. 2021. Neurocan genome-wide psychiatric risk variant affects explicit memory performance and hippocampal function in healthy humans. European Journal of Neuroscience. 53(12):3942-3959. https://doi.org/10.1111/ejn.14872
Martens L, Herrmann L, Colic L, Li M, Richter A, Behnisch G, Stork O, Seidenbecher C, Schott BH, Walter M. 2021. Met carriers of the BDNF Val66Met polymorphism show reduced Glx/NAA in the pregenual ACC in two independent cohorts. Scientific Reports. 11(1):Article 6742. https://doi.org/10.1038/s41598-021-86220-3
Vemula SK, Malci A, Junge L, Lehmann AC, Rama R, Hradsky J, Matute RA, Weber A, Prigge M, Naumann M, et al. 2020. The Interaction of TRAF6 With Neuroplastin Promotes Spinogenesis During Early Neuronal Development. Frontiers in Cell and Developmental Biology. 8:Article 579513. https://doi.org/10.3389/fcell.2020.579513
Betts MJ, Richter A, de Boer L, Tegelbeckers J, Perosa V, Baumann V, Chowdhury R, Dolan RJ, Seidenbecher C, Schott BH, et al. 2020. Learning in anticipation of reward and punishment: perspectives across the human lifespan. Neurobiology of Aging. 96:49-57. https://doi.org/10.1016/j.neurobiolaging.2020.08.011
Mitlöhner J, Kaushik R, Niekisch H, Blondiaux A, Gee CE, Happel MFK, Gundelfinger E, Dityatev A, Frischknecht R, Seidenbecher C. 2020. Dopamine Receptor Activation Modulates the Integrity of the Perisynaptic Extracellular Matrix at Excitatory Synapses. Cells. 9(2):Article 260. https://doi.org/10.3390/cells9020260
Bordone MP, Salman MM, Titus HE, Amini E, Andersen JV, Chakraborti B, Diuba AV, Dubouskaya TG, Ehrke E, Freitas AE, et al. 2019. The energetic brain - A review from students to students. Journal of Neurochemistry. 151(2):139-165. https://doi.org/10.1111/jnc.14829
Schott BH, Wüstenberg T, Lücke E, Pohl IM, Richter A, Seidenbecher CI, Pollmann S, Kizilirmak JM, Richardson-Klavehn A. 2019. Gradual acquisition of visuospatial associative memory representations via the dorsal precuneus. Human Brain Mapping. 40(5):1554-1570. https://doi.org/10.1002/hbm.24467
Colic L, Li M, Demenescu LR, Li S, Müller I, Richter A, Behnisch G, Seidenbecher CI, Speck O, Schott BH, et al. 2018. GAD65 promoter polymorphism rs2236418 modulates harm avoidance in women via inhibition/excitation balance in the rostral ACC. Journal of Neuroscience. 38(22):5067-5077. https://doi.org/10.1523/JNEUROSCI.1985-17.2018
Korthals M, Langnaese K, Smalla KH, Kähne T, Herrera-Molina R, Handschuh J, Lehmann AC, Mamula D, Naumann M, Seidenbecher C, et al. 2017. A complex of Neuroplastin and Plasma Membrane Ca²⁺ ATPase controls T cell activation. Scientific Reports. 7(1):Article 8358. https://doi.org/10.1038/s41598-017-08519-4
Richter A, Barman A, Wüstenberg T, Soch J, Schanze D, Deibele A, Behnisch G, Assmann A, Klein M, Zenker M, et al. 2017. Behavioral and neural manifestations of reward memory in carriers of low-expressing versus high-expressing genetic variants of the dopamine D2 receptor. Frontiers in Psychology. 8(MAY):Article 654. https://doi.org/10.3389/fpsyg.2017.00654
Lepeta K, Lourenco MV, Schweitzer BC, Martino Adami PV, Banerjee P, Catuara-Solarz S, de La Fuente Revenga M, Guillem AM, Haidar M, Ijomone OM, et al. 2016. Synaptopathies: synaptic dysfunction in neurological disorders – A review from students to students. Journal of Neurochemistry. 138(6):785-805. https://doi.org/10.1111/jnc.13713
Kähne T, Richter S, Kolodziej A, Smalla KH, Pielot R, Engler A, Ohl FW, Dieterich DC, Seidenbecher C, Tischmeyer W, et al. 2016. Proteome rearrangements after auditory learning: high-resolution profiling of synapse-enriched protein fractions from mouse brain. Journal of Neurochemistry. 138(1):124-138. https://doi.org/10.1111/jnc.13636
Lubbers BR, Matos MR, Horn A, Visser E, Van Der Loo RC, Gouwenberg Y, Meerhoff GF, Frischknecht R, Seidenbecher CI, Smit AB, et al. 2016. The Extracellular Matrix Protein Brevican Limits Time-Dependent Enhancement of Cocaine Conditioned Place Preference. Neuropsychopharmacology. 41(7):1907-1916. https://doi.org/10.1038/npp.2015.361
Barman A, Richter S, Soch J, Deibele A, Richter A, Assmann A, Wüstenberg T, Walter H, Seidenbecher CI, Schott BH. 2015. Gender-specific modulation of neural mechanisms underlying social reward processing by Autism Quotient. Social Cognitive and Affective Neuroscience. 10(11):1537-1547. https://doi.org/10.1093/scan/nsv044
Blosa M, Sonntag M, Jäger C, Weigel S, Seeger J, Frischknecht R, Seidenbecher CI, Matthews RT, Arendt T, Rübsamen R, et al. 2015. The extracellular matrix molecule brevican is an integral component of the machinery mediating fast synaptic transmission at the calyx of Held. Journal of Physiology. 593(19):4341-4360. https://doi.org/10.1113/JP270849
Valenzuela Macaya JC, Heise C, Franken G, Singh J, Schweitzer B, Seidenbecher CI, Frischknecht R. 2014. Hyaluronan-based extracellular matrix under conditions of homeostatic plasticity. Philosophical Transactions of the Royal Society B: Biological Sciences. 369(1654). https://doi.org/10.1098/rstb.2013.0606
Beesley PW, Herrera-Molina R, Smalla KH, Seidenbecher C. 2014. The Neuroplastin adhesion molecules: key regulators of neuronal plasticity and synaptic function. Journal of Neurochemistry. 131(3):268-283. https://doi.org/10.1111/jnc.12816
Richter A, Guitart-Masip M, Barman A, Libeau C, Behnisch G, Czerney S, Schanze D, Assmann A, Klein M, Düzel E, et al. 2014. Valenced action/inhibition learning in humans is modulated by a genetic variant linked to dopamine D2 receptor expression. Frontiers in Systems Neuroscience. 8(AUG):Article 140. https://doi.org/10.3389/fnsys.2014.00140
Barman A, Assmann A, Richter S, Soch J, Schütze H, Wüstenberg T, Deibele A, Klein M, Richter A, Behnisch G, et al. 2014. Genetic variation of the RASGRF1 regulatory region affects human hippocampus-dependent memory. Frontiers in Human Neuroscience. 8:Article 260. https://doi.org/10.3389/fnhum.2014.00260
Herrera Molina R, Sarto-Jackson I, Montenegro-Venegas C, Heine M, Smalla KH, Seidenbecher CI, Beesley PW, Gundelfinger ED, Montag D. 2014. Structure of excitatory synapses and GABAA receptor localization at inhibitory synapses are regulated by neuroplastin-65. Journal of Biological Chemistry. 289(13):8973-8988. https://doi.org/10.1074/jbc.M113.514992
Schott BH, Assmann A, Schmierer P, Soch J, Erk S, Garbusow M, Mohnke S, Pöhland L, Romanczuk-Seiferth N, Barman A, et al. 2014. Epistatic interaction of genetic depression risk variants in the human subgenual cingulate cortex during memory encoding. Translational Psychiatry. 4(3):e372. https://doi.org/10.1038/tp.2014.10
Mawrin C, Seidenbecher C. 2014. Glioma and Extracellular Matrix. Sedo A, Mentlein R, editors. In Glioma Cell Biology. Vienna: Springer.
Frischknecht R, Chang KJ, Rasband MN, Seidenbecher CI. 2014. Neural ECM molecules in axonal and synaptic homeostatic plasticity. Progress in Brain Research. 214:81-100. https://doi.org/10.1016/B978-0-444-63486-3.00004-9
Bernstein HG, Dobrowolny H, Schott BH, Gorny X, Becker V, Steiner J, Seidenbecher CI, Bogerts B. 2013. Increased density of AKAP5-expressing neurons in the anterior cingulate cortex of subjects with bipolar disorder. Journal of Psychiatric Research. 47(6):699-705. https://doi.org/10.1016/j.jpsychires.2012.12.020
Richter A, Richter S, Barman A, Soch J, Klein M, Assmann A, Libeau C, Behnisch G, Wüstenberg T, Seidenbecher CI, et al. 2013. Motivational salience and genetic variability of dopamine D2 receptor expression interact in the modulation of interference processing. Frontiers in Human Neuroscience. 7(MAY). https://doi.org/10.3389/fnhum.2013.00250
Susuki K, Chang KJ, Zollinger DR, Liu Y, Ogawa Y, Eshed-Eisenbach Y, Dours-Zimmermann MT, Oses-Prieto JA, Burlingame AL, Seidenbecher CI, et al. 2013. Three mechanisms assemble central nervous system nodes of ranvier. Neuron. 78(3):469-482. https://doi.org/10.1016/j.neuron.2013.03.005
Schott BH, Wüstenberg T, Wimber M, Fenker DB, Zierhut KC, Seidenbecher CI, Heinze HJ, Walter H, Düzel E, Richardson-Klavehn A. 2013. The relationship between level of processing and hippocampal-cortical functional connectivity during episodic memory formation in humans. Human Brain Mapping. 34(2):407-424. https://doi.org/10.1002/hbm.21435
Richter S, Gorny X, Machts J, Behnisch G, Wüstenberg T, Herbort MC, Münte TF, Seidenbecher CI, Schott BH. 2013. Effects of AKAP5 Pro100Leu Genotype on Working Memory for Emotional Stimuli. PLoS ONE. 8(1):Article e55613. https://doi.org/10.1371/journal.pone.0055613
Seeger C, Gorny X, Reddy PP, Seidenbecher C, Danielson UH. 2012. Kinetic and mechanistic differences in the interactions between caldendrin and calmodulin with AKAP79 suggest different roles in synaptic function. Journal of Molecular Recognition. 25(10):495-503. https://doi.org/10.1002/jmr.2215
Miró X, Meier S, Dreisow ML, Frank J, Strohmaier J, Breuer R, Schmäl C, Albayram Ö, Pardo-Olmedilla MT, Mühleisen TW, et al. 2012. Studies in humans and mice implicate neurocan in the etiology of mania. American Journal of Psychiatry. 169(9):982-990. https://doi.org/10.1176/appi.ajp.2012.11101585
Gorny X, Mikhaylova M, Seeger C, Reddy PP, Reissner C, Schott BH, Helena Danielson U, Kreutz MR, Seidenbecher C. 2012. AKAP79/150 interacts with the neuronal calcium-binding protein caldendrin. Journal of Neurochemistry. 122(4):714-726. https://doi.org/10.1111/j.1471-4159.2012.07828.x
Frischknecht R, Seidenbecher CI. 2012. Brevican: A key proteoglycan in the perisynaptic extracellular matrix of the brain. International Journal of Biochemistry and Cell Biology. 44(7):1051-1054. https://doi.org/10.1016/j.biocel.2012.03.022
Herrera-Molina R, Frischknecht R, Maldonado H, Seidenbecher CI, Gundelfinger ED, Hetz C, de la Luz Aylwin M, Schneider P, Quest AFG, Leyton L. 2012. Astrocytic α _vβ ₃ integrin inhibits neurite outgrowth and promotes retraction of neuronal processes by clustering thy-1. PLoS ONE. 7(3):e34295. https://doi.org/10.1371/journal.pone.0034295
Richter S, Gorny X, Marco-Pallares J, Krämer UM, Machts J, Barman A, Bernstein HG, Schüle R, Schöls L, Rodriguez-Fornells A, et al. 2011. A potential role for a genetic variation of AKAP₅ in human aggression and anger control. Frontiers in Human Neuroscience. 5(DEC):Article 175. https://doi.org/10.3389/fnhum.2011.00175
Heyden A, Ionescu MCS, Romorini S, Kracht B, Ghiglieri V, Calabresi P, Seidenbecher C, Angenstein F, Gundelfinger ED. 2011. Hippocampal enlargement in Bassoon-mutant mice is associated with enhanced neurogenesis, reduced apoptosis, and abnormal BDNF levels. Cell and Tissue Research. 346(1):11-26. https://doi.org/10.1007/s00441-011-1233-3
Wimber M, Schott BH, Wendler F, Seidenbecher CI, Behnisch G, Macharadze T, Bäuml KHT, Richardson-Klavehn A. 2011. Prefrontal dopamine and the dynamic control of human long-term memory. Translational Psychiatry. 1:Article e15. https://doi.org/10.1038/tp.2011.15
Schott BH, Seidenbecher CI, Richter S, Wüstenberg T, Debska-Vielhaber G, Schubert H, Heinze HJ, Richardson-Klavehn A, Düzel E. 2011. Genetic variation of the serotonin 2a receptor affects hippocampal novelty processing in humans. PLoS ONE. 6(1):e15984. https://doi.org/10.1371/journal.pone.0015984
Zweynert S, Pade JP, Wüstenberg T, Sterzer P, Walter H, Seidenbecher CI, Richardson-Klavehn A, Düzel E, Schott BH. 2011. Motivational salience modulates hippocampal repetition suppression and functional connectivity in humans. Frontiers in Human Neuroscience. 5:144. https://doi.org/10.3389/fnhum.2011.00144
Pyka M, Busse C, Seidenbecher C, Gundelfinger ED, Faissner A. 2011. Astrocytes are crucial for survival and maturation of embryonic hippocampal neurons in a neuron-glia cell-insert coculture assay. Synapse. 65(1):41-53. https://doi.org/10.1002/syn.20816
Dityatev A, Seidenbecher CI, Schachner M. 2010. Compartmentalization from the outside: The extracellular matrix and functional microdomains in the brain. Trends in Neurosciences. 33(11):503-512. https://doi.org/10.1016/j.tins.2010.08.003
Faissner A, Pyka M, Geissler M, Sobik T, Frischknecht R, Gundelfinger ED, Seidenbecher C. 2010. Contributions of astrocytes to synapse formation and maturation - Potential functions of the perisynaptic extracellular matrix. Brain Research Reviews. 63(1-2):26-38. https://doi.org/10.1016/j.brainresrev.2010.01.001
Schott BH, Frischknecht R, Debska-Vielhaber G, John N, Behnisch G, Düzel E, Gundelfinger ED, Seidenbecher CI. 2010. Membrane-bound catechol-O-methyl transferase in cortical neurons and glial cells is intracellularly oriented. Frontiers in Psychiatry. 1(OCT):Article Article 142. https://doi.org/10.3389/fpsyt.2010.00142
Frischknecht R, Heine M, Perrais D, Seidenbecher CI, Choquet D, Gundelfinger ED. 2009. Brain extracellular matrix affects AMPA receptor lateral mobility and short-term synaptic plasticity. Neuroforum. 15(3):94-95. https://doi.org/10.1515/nf-2009-0304
Frischknecht R, Heine M, Perrais D, Seidenbecher CI, Choquet D, Gundelfinger ED. 2009. Brain extracellular matrix affects AMPA receptor lateral mobility and short-term synaptic plasticity. Nature Neuroscience. 12(7):897-904. https://doi.org/10.1038/nn.2338
Schott BH, Minuzzi L, Krebs RM, Elmenhorst D, Lang M, Winz OH, Seidenbecher CI, Coenen HH, Heinze HJ, Zilles K, et al. 2008. Mesolimbic functional magnetic resonance imaging activations during reward anticipation correlate with reward-related ventral striatal dopamine release. Journal of Neuroscience. 28(52):14311-14319. https://doi.org/10.1523/JNEUROSCI.2058-08.2008
Schicknick H, Schott BH, Budinger E, Smalla KH, Riedel A, Seidenbecher CI, Scheich H, Gundelfinger ED, Tischmeyer W. 2008. Dopaminergic modulation of auditory cortex-dependent memory consolidation through mTOR. Cerebral Cortex. 18(11):2646-2658. https://doi.org/10.1093/cercor/bhn026
Frischknecht R, Seidenbecher CI. 2008. The crosstalk of hyaluronan-based extracellular matrix and synapses. Neuron Glia Biology. 4(3):249-257. https://doi.org/10.1017/S1740925X09990226
Heyden A, Angenstein F, Sallaz M, Seidenbecher C, Montag D. 2008. Abnormal axonal guidance and brain anatomy in mouse mutants for the cell recognition molecules close homolog of L1 and NgCAM-related cell adhesion molecule. Neuroscience. 155(1):221-233. https://doi.org/10.1016/j.neuroscience.2008.04.080
Dieterich DC, Karpova A, Mikhaylova M, Zdobnova I, König I, Landwehr M, Kreutz M, Smalla KH, Richter K, Landgraf P, et al. 2008. Caldendrin-Jacob: A protein liaison that couples NMDA receptor signalling to the nucleus. PLoS Biology. 6(2):286-306. https://doi.org/10.1371/journal.pbio.0060034
Quaglia X, Beggah AT, Seidenbecher C, Zurn AD. 2008. Delayed priming promotes CNS regeneration post-rhizotomy in Neurocan and Brevican-deficient mice. Brain. 131(1):240-249. https://doi.org/10.1093/brain/awm279
Schott BH, Niehaus L, Wittmann BC, Schütze H, Seidenbecher CI, Heinze HJ, Düzel E. 2007. Ageing and early-stage Parkinson's disease affect separable neural mechanisms of mesolimbic reward processing. Brain. 130(9):2412-2424. https://doi.org/10.1093/brain/awm147
Hedstrom KL, Xu X, Ogawa Y, Frischknecht R, Seidenbecher CI, Shrager P, Rasband MN. 2007. Neurofascin assembles a specialized extracellular matrix at the axon initial segment. Journal of Cell Biology. 178(5):875-886. https://doi.org/10.1083/jcb.200705119
Dityatev A, Frischknecht R, Seidenbecher C. 2006. Extracellular Matrix and Synaptic Functions. Gundelfinger ED, Seidenbecher C, Schraven B, editors. In Cell Communication in Nervous and Immune System. Springer. pp. 69-97. (Results and Problems in Cell Differentiation). https://doi.org/10.1007/400_025
John N, Krügel H, Frischknecht R, Smalla KH, Schultz C, Kreutz MR, Gundelfinger ED, Seidenbecher CI. 2006. Brevican-containing perineuronal nets of extracellular matrix in dissociated hippocampal primary cultures. Molecular and Cellular Neurosciences. 31(4):774-784. https://doi.org/10.1016/j.mcn.2006.01.011
Krügel H, Becker A, Polten A, Grecksch G, Singh R, Berg A, Seidenbecher C, Saluz HP. 2006. Transcriptional response to the neuroleptic-like compound Ampullosporin A in the rat ketamine model.Journal of Neurochemistry. 97 Suppl 1:74-81. https://doi.org/10.1111/j.1471-4159.2005.03621.x
Schott BH, Seidenbecher CI, Fenker DB, Lauer CJ, Bunzeck N, Bernstein HG, Tischmeyer W, Gundelfinger ED, Heinze HJ, Düzel E. 2006. The dopaminergic midbrain participates in human episodic memory formation: Evidence from genetic imaging. Journal of Neuroscience. 26(5):1407-1417. https://doi.org/10.1523/JNEUROSCI.3463-05.2006
Held-Feindt J, Paredes EB, Blömer U, Seidenbecher C, Stark AM, Mehdorn HM, Mentlein R. 2006. Matrix-degrading proteases ADAMTS4 and ADAMTS5 (disintegrins and metalloproteinases with thrombospondin motifs 4 and 5) are expressed in human glioblastomas. International Journal of Cancer. 118(1):55-61. https://doi.org/10.1002/ijc.21258
Kreutz MR, Seidenbecher C, Gundelfinger ED. 2006. Caldendrin- a neuronal calcium binding protein involved in synaptro-dendritic Ca2+ signaling. Philippov PP, Koch K-W, editors. In Neuronal Calcium Sensor Proteins. New York: Nova Science Publishers. pp. 301-313.
Gundelfinger ED, Seidenbecher C, Schraven B, ed. 2006. Cell Communication in Nervous and Immune System. 1 ed. Heidelberg: Springer Verlag. 313 p. (Results and Problems in Cell Differentiation). https://doi.org/10.1007/11372318
Gundelfinger ED, Seidenbecher C, Schraven B. 2006. Preface. Gundelfinger ED, Seidenbecher C, Schraven B, editors. In Cell Communication in Nervous and Immune System. Springer. pp. v-vii. ( Results and Problems in Cell Differentiation ).
Seidenbecher CI, Landwehr M, Smalla KH, Kreutz M, Dieterich DC, Zuschratter W, Reissner C, Hammarback JA, Böckers TM, Gundelfinger ED, et al. 2004. Caldendrin but not Calmodulin Binds to Light Chain 3 of MAP1A/B: An Association with the Microtubule Cytoskeleton Highlighting Exclusive Binding Partners for Neuronal Ca²⁺-sensor Proteins. Journal of Molecular Biology. 336(4):957-970. https://doi.org/10.1016/j.jmb.2003.12.054
Smalla KH, Seidenbecher CI, Tischmeyer W, Schicknick H, Wyneken U, Böckers TM, Gundelfinger ED, Kreutz MR. 2003. Kainate-induced epileptic seizures induce a recruitment of caldendrin to the postsynaptic density in rat brain. Molecular Brain Research. 116(1-2):159-162. https://doi.org/10.1016/S0169-328X(03)00235-3
Bernstein HG, Seidenbecher CI, Smalla KH, Gundelfinger ED, Bogerts B, Kreutz MR. 2003. Distribution and cellular localization of caldendrin immunoreactivity in adult human forebrain. Journal of Histochemistry and Cytochemistry. 51(8):1109-1112. https://doi.org/10.1177/002215540305100816
Tischmeyer W, Schicknick H, Kraus M, Seidenbecher CI, Staak S, Scheich H, Gundelfinger ED. 2003. Rapamycin-sensitive signalling in long-term consolidation of auditory cortex-dependent memory. European Journal of Neuroscience. 18(4):942-950. https://doi.org/10.1046/j.1460-9568.2003.02820.x
Brakebusch C, Seidenbecher CI, Asztely F, Rauch U, Matthies H, Meyer H, Krug M, Böckers TM, Zhou X, Kreutz MR, et al. 2002. Brevican-deficient mice display impaired hippocampal CA1 long-term potentiation but show no obvious deficits in learning and memory. Molecular and Cellular Biology. 22(21):7417-7427. https://doi.org/10.1128/MCB.22.21.7417-7427.2002
Seidenbecher CI, Smalla KH, Fischer N, Gundelfinger ED, Kreutz MR. 2002. Brevican isoforms associate with neural membranes. Journal of Neurochemistry. 83(3):738-746. https://doi.org/10.1046/j.1471-4159.2002.01183.x
Laube G, Seidenbecher CI, Richter K, Dieterich DC, Hoffmann B, Landwehr M, Smalla KH, Winter C, Böckers TM, Wolf G, et al. 2002. The neuron-specific Ca²⁺-binding protein caldendrin: Gene structure, splice isoforms, and expression in the rat central nervous system. Molecular and Cellular Neurosciences. 19(3):459-475. https://doi.org/10.1006/mcne.2001.1078
Seidenbecher CI, Reissner C, Kreutz MR. 2002. Caldendrins in the inner retina. Experimental Biology and Medicine. 514:451-463. https://doi.org/10.1007/978-1-4615-0121-3_27
Zhou XH, Brakebusch C, Matthies H, Oohashi T, Hirsch E, Moser M, Krug M, Seidenbecher CI, Boeckers TM, Rauch U, et al. 2001. Neurocan is dispensable for brain development. Molecular and Cellular Biology. 21(17):5970-5978. https://doi.org/10.1128/MCB.21.17.5970-5978.2001
Kreutz MR, Langnäse K, Dieterich DC, Seidenbecher CI, Zuschratter W, Beesley PW, Gundelfinger ED. 2001. Distribution of transcript and protein isoforms of the synaptic glycoprotein neuroplastin in rat retina. Investigative Ophthalmology and Visual Science. 42(8):1907-1914.
Brückner G, Grosche J, Schmidt S, Härtig W, Margolis RU, Delpech B, Seidenbecher CI, Czaniera R, Schachner M. 2000. Postnatal development of perineuronal nets in wild-type mice and in a mutant deficient in tenascin-R. Journal of Comparative Neurology. 428(4):616-629. https://doi.org/10.1002/1096-9861(20001225)428:4<616::AID-CNE3>3.0.CO;2-K
Boeckers TM, Winter C, Smalla KH, Kreutz MR, Bockmann J, Seidenbecher C, Garner CC, Gundelfinger ED. 1999. Proline-rich synapse-associated proteins ProSAP1 and ProSAP2 interact with synaptic proteins of the SAPAP/GKAP family. Biochemical and Biophysical Research Communications. 264(1):247-252. https://doi.org/10.1006/bbrc.1999.1489
Menger N, Seidenbecher CI, Gundelfinger ED, Kreutz MR. 1999. The Cytoskeleton-associated neuronal calcium-binding protein caldendrin is expressed in a subset of amacrine, bipolar and ganglion cells of the rat retina. Cell and Tissue Research. 298(1):21-32. https://doi.org/10.1007/s004419900060
Kreutz MR, Bien A, Vorwerk CK, Böckers TM, Seidenbecher CI, Tischmeyer W, Sabel BA. 1999. Co-expression of c-Jun and ATF-2 characterizes the surviving retinal ganglion cells which maintain axonal connections after partial optic nerve injury. Molecular Brain Research. 69(2):232-241. https://doi.org/10.1016/S0169-328X(99)00113-8
Bien A, Seidenbecher CI, Böckers TM, Sabel BA, Kreutz MR. 1999. Apoptotic versus necrotic characteristics of retinal ganglion cell death after partial optic nerve injury. Journal of Neurotrauma. 16(2):153-163. https://doi.org/10.1089/neu.1999.16.153
Kreutz MR, Seidenbecher CI, Sabel BA. 1999. Molecular plasticity of retinal ganglion cells after partial optic nerve injury. Restorative Neurology and Neuroscience. 14(2-3):127-134.
Kreutz MR, Böckers TM, Bockmann J, Seidenbecher CI, Kracht B, Vorwerk CK, Weise J, Sabel BA. 1998. Axonal injury alters alternative splicing of the retinal NR1 receptor: The preferential expression of the NR1b isoforms is crucial for retinal ganglion cell survival. Journal of Neuroscience. 18(20):8278-8291.
Seidenbecher CI, Langnäse K, Sanmartí-Vila L, Boeckers TM, Smalla KH, Sabel BA, Garner CC, Gundelfinger ED, Kreutz MR. 1998. Caldendrin, a novel neuronal calcium-binding protein confined to the somato-dendritic compartment. Journal of Biological Chemistry. 273(33):21324-21331. https://doi.org/10.1074/jbc.273.33.21324
Seidenbecher CI, Gundelfinger ED, Böckers TM, Trotter J, Kreutz MR. 1998. Transcripts for secreted and GPI-anchored brevican are differentially distributed in rat brain. European Journal of Neuroscience. 10(5):1621-1630. https://doi.org/10.1046/j.1460-9568.1998.00166.x
Rauch U, Meyer H, Brakebusch C, Seidenbecher C, Gundelfinger ED, Beier DR, Fässler R. 1997. Sequence and chromosomal localization of the mouse brevican gene. Genomics. 44(1):15-21. https://doi.org/10.1006/geno.1997.4853
Seidenbecher C, Richter K, Gundelfinger ED. 1997. Brevican, a conditional proteoglycan from rat brain: Characterisation of secreted and GPI-Anchored Isoforms. Teelken A, Korf J, editors. In Neurochemistry: Cellular, Molecular, and clinical aspects. New York and London: Plenum Press. pp. 901-904.
Langnaese K, Seidenbecher C, Wex H, Seidel B, Hartung K, Appeltauer U, Garner A, Voss B, Mueller B, Garner CC, et al. 1996. Protein components of a rat brain synaptic junctional protein preparation. Molecular Brain Research. 42(1):118-122. https://doi.org/10.1016/S0169-328X(96)00147-7
Chung WJ, Kindler S, Seidenbecher C, Garner CC. 1996. MAP2a, an alternatively spliced variant of microtubule-associated protein 2. Journal of Neurochemistry. 66(3):1273-1281.
Seidenbecher CI, Richter K, Rauch U, Fassler R, Garner CC, Gundelfinger ED. 1995. Brevican, a chondroitin sulfate proteoglycan of rat brain, occurs as secreted and cell surface glycosylphosphatidylinositol-anchored isoforms. Journal of Biological Chemistry. 270(45):27206-27212. https://doi.org/10.1074/jbc.270.45.27206
Reinbothe S, Reinbothe C, Heintzen C, Seidenbecher C, Parthier B. 1993. A methyl jasmonate-induced shift in the length of the 5' untranslated region impairs translation of the plastid rbcL transcript in barley. EMBO Journal. 12(4):1505-1512.
Drittmittel
Drittmittel
2023 - 2027 (DFG)
SynAGE Teilprojekt A1_Sub in Squad A (Dityatev/Seidenbecher): Mechanotransduction and the ageing synapse – Rejuvenating ECM, Piezo1 and Hippo signalling at perisynaptic sites
2023 - 2027 (DFG)
SynAGE Teilprojekt C1_Sub in Squad C (Kreutz/Seidenbecher): Synaptic insulin resistance at the basis of trajectories towards cognitive decline in high-risk ageing
2020 - 2024 (DFG)
SFB 1436 TP A05: Die Integrität der Extrazellulären Matrix als neuronale Ressource kognitiver Flexibilität
https://sfb1436.de/
2019 - 2023 (DFG)
Die alternde Synapse - molekulare, zelluläre und verhaltensbiologische Mechanismen des kognitiven Leistungsabfalls
2014 - 2019 (DFG)
SFB 779/ B14: Zusammenspiel vom dopaminergen System und der Extrazellulärmatrix beim aversiven Lernen
http://www.sfb779.de/
2012 - 2016 (DFG)
SFB 779/ A08: Genetische Einflüsse auf die Modulation von Aufmerksamkeit und Gedächtnis durch Belohnung und Bestrafung
http://www.sfb779.de/
2011 - 2015 (WGL)
SAW-2011-IfN-4: TP 2: Imaging Genetics kognitiver Funtkionen