LIN Personal

Dr. Jürgen Goldschmidt

Arbeitsgruppenleiter

Combinatorial NeuroImaging

Leibniz-Institut für Neurobiologie
Brenneckestr. 6
39118 Magdeburg
Deutschland
Telefon: +49 391 6263 95421
E-Mail: Juergen.Goldschmidt@lin-magdeburg.de
ORCID: 0000-0002-6986-9914

  • Publikationen

    Publikationen

    Muehlberg F, Mohnike K, Grosser OS, Pech M, Goldschmidt J, Smalla K-H, Seidensticker R, Ümütlü MR, Deniz S, Ricke J, et al. 2024. In vivo evaluation of tumor uptake and bio-distribution of 99mTc-labeled 1-thio-β-D-glucose and 5-thio-D-glucose in mice model. EJNMMI radiopharmacy and chemistry. 9(1):Article 26. https://doi.org/10.1186/s41181-024-00253-3

    Oelschlegel AM, Bhattacharjee R, Wenk P, Harit K, Rothkötter H-J, Koch SP, Boehm-Sturm P, Matuschewski K, Budinger E, Schlüter D, et al. 2024. Beyond the microcirculation: sequestration of infected red blood cells and reduced flow in large draining veins in experimental cerebral malaria. Nature Communications. 15(1):Article 2396. https://doi.org/10.1038/s41467-024-46617-w

    Grochowska KM, Gomes GM, Raman R, Kaushik R, Sosulina L, Kaneko H, Oelschlegel AM, Yuanxiang P, Reyes-Resina I, Bayraktar G, et al. 2023. Jacob-induced transcriptional inactivation of CREB promotes Aβ-induced synapse loss in Alzheimer's disease. The EMBO journal. 42(4):Article e112453. https://doi.org/10.15252/embj.2022112453

    Prior MJW, Bast T, McGarrity S, Goldschmidt J, Vincenz D, Seaton A, Hall G, Pitiot A. 2021. Ratlas-LH: An MRI template of the Lister hooded rat brain with stereotaxic coordinates for neurosurgical implantations. Brain and neuroscience advances. 5:Article 23982128211036332. https://doi.org/10.1177/23982128211036332

    Lin X, Brunk MGK, Yuanxiang P, Curran AW, Zhang E, Stöber F, Goldschmidt J, Gundelfinger ED, Vollmer M, Happel MFK, et al. 2021. Neuroplastin expression is essential for hearing and hair cell PMCA expression. Brain Structure and Function. 226(5):1533-1551. https://doi.org/10.1007/s00429-021-02269-w

    Braun K, Mannewitz A, Bock J, Kreitz S, Hess A, Scheich H, Goldschmidt J. 2021. Imaging of Functional Brain Circuits during Acquisition and Memory Retrieval in an Aversive Feedback Learning Task: Single Photon Emission Computed Tomography of Regional Cerebral Blood Flow in Freely Behaving Rats. Brain Sciences. 11(5):Article 659. https://doi.org/10.3390/brainsci11050659

    Goldschmidt J, Oelschlegel A. 2020. Functional Neuroimaging in Rodents Using Cerebral Blood Flow SPECT. Frontiers in Physics. 8:Article 152. https://doi.org/10.3389/fphy.2020.00152

    Weidner TC, Vincenz D, Brocka M, Tegtmeier J, Oelschlegel AM, Ohl FW, Goldschmidt J, Lippert MT. 2020. Matching stimulation paradigms resolve apparent differences between optogenetic and electrical VTA stimulation. Brain Stimulation. 13(2):363-371. https://doi.org/10.1016/j.brs.2019.11.005

    Edelmann B, Gupta N, Schnoeder TM, Oelschlegel AM, Shahzad K, Goldschmidt J, Philipsen L, Weinert S, Ghosh A, Saalfeld FC, et al. 2018. JAK2-V617F promotes venous thrombosis through β1/β2 integrin activation. Journal of Clinical Investigation. 128(10):4359-4371. https://doi.org/10.1172/JCI90312

    Brocka M, Helbing C, Vincenz D, Scherf T, Montag D, Goldschmidt J, Angenstein F, Lippert M. 2018. Contributions of dopaminergic and non-dopaminergic neurons to VTA-stimulation induced neurovascular responses in brain reward circuits. NeuroImage. 177:88-97. https://doi.org/10.1016/j.neuroimage.2018.04.059

    Mannewitz A, Bock J, Kreitz S, Hess A, Goldschmidt J, Scheich H, Braun K. 2018. Comparing brain activity patterns during spontaneous exploratory and cue-instructed learning using single photon-emission computed tomography (SPECT) imaging of regional cerebral blood flow in freely behaving rats. Brain Structure and Function. 223(4):2025-2038. https://doi.org/10.1007/s00429-017-1605-x

    Henschke JU, Oelschlegel AM, Angenstein F, Ohl FW, Goldschmidt J, Kanold PO, Budinger E. 2018. Early sensory experience influences the development of multisensory thalamocortical and intracortical connections of primary sensory cortices. Brain Structure and Function. 223(3):1165-1190. https://doi.org/10.1007/s00429-017-1549-1

    Pöttker B, Stöber F, Hummel R, Angenstein F, Radyushkin K, Goldschmidt J, Schäfer MKE. 2017. Traumatic brain injury causes long-term behavioral changes related to region-specific increases of cerebral blood flow. Brain Structure and Function. 222(9):4005-4021. https://doi.org/10.1007/s00429-017-1452-9

    Vincenz D, Wernecke KEA, Fendt M, Goldschmidt J. 2017. Habenula and interpeduncular nucleus differentially modulate predator odor-induced innate fear behavior in rats. Behavioural Brain Research. 332:164-171. https://doi.org/10.1016/j.bbr.2017.05.053

    Herrera-Molina R, Mlinac-Jerkovic K, Ilic K, Stöber F, Vemula SK, Sandoval M, Milosevic NJ, Simic G, Smalla KH, Goldschmidt J, et al. 2017. Neuroplastin deletion in glutamatergic neurons impairs selective brain functions and calcium regulation: Implication for cognitive deterioration. Scientific Reports. 7(1):Article 7273. https://doi.org/10.1038/s41598-017-07839-9

    Schulz J, Rohracker M, Stiebler M, Goldschmidt J, Stöber F, Noriega M, Pethe A, Lukas M, Osterkamp F, Reineke U, et al. 2017. Proof of therapeutic efficacy of a 177Lu-labeled neurotensin receptor 1 antagonist in a colon carcinoma xenograft model. Journal of Nuclear Medicine. 58(6):936-941. https://doi.org/10.2967/jnumed.116.185140

    Töpperwien M, Krenkel M, Vincenz D, Stöber F, Oelschlegel AM, Goldschmidt J, Salditt T. 2017. Three-dimensional mouse brain cytoarchitecture revealed by laboratory-based x-ray phase-contrast tomography. Scientific Reports. 7:Article 42847. https://doi.org/10.1038/srep42847

    Bhattacharya S, Herrera-Molina R, Sabanov V, Ahmed T, Iscru E, Stöber F, Richter K, Fischer KD, Angenstein F, Goldschmidt J, et al. 2017. Genetically induced retrograde amnesia of associative memories after neuroplastin ablation. Biological Psychiatry. 81(2):124-135. https://doi.org/10.1016/j.biopsych.2016.03.2107

    Vogel H, Wolf S, Rabasa C, Rodriguez-Pacheco F, Babaei CS, Stöber F, Goldschmidt J, DiMarchi RD, Finan B, Tschöp MH, et al. 2016. GLP-1 and estrogen conjugate acts in the supramammillary nucleus to reduce food-reward and body weight. Neuropharmacology. 110(Pt A):396-406. https://doi.org/10.1016/j.neuropharm.2016.07.039

    Radtke-Schuller S, Schuller G, Angenstein F, Grosser OS, Goldschmidt J, Budinger E. 2016. Brain atlas of the Mongolian gerbil (Meriones unguiculatus) in CT/MRI-aided stereotaxic coordinates. Brain Structure and Function. 221 Suppl 1(Suppl. 1):1-272. https://doi.org/10.1007/s00429-016-1259-0

    Schulz J, Rohracker M, Stiebler M, Goldschmidt J, Grosser OS, Osterkamp F, Pethe A, Reineke U, Smerling C, Amthauer H. 2016. Comparative evaluation of the biodistribution profiles of a series of nonpeptidic neurotensin receptor-1 antagonists reveals a promising candidate for theranostic applications. Journal of Nuclear Medicine. 57(7):1120-1123. https://doi.org/10.2967/jnumed.115.170530

    Wanger T, Wetzel W, Scheich H, Ohl FW, Goldschmidt J. 2015. Spatial patterns of neuronal activity in rat cerebral cortex during non-rapid eye movement sleep. Brain Structure and Function. 220(6):3469-3484. https://doi.org/10.1007/s00429-014-0867-9

    Janitzky K, Lippert MT, Engelhorn A, Tegtmeier J, Goldschmidt J, Heinze HJ, Ohl FW. 2015. Optogenetic silencing of locus coeruleus activity in mice impairs cognitive flexibility in an attentional set-shifting task. Frontiers in Behavioral Neuroscience. 9(NOVEMBER):Article 286. https://doi.org/10.3389/fnbeh.2015.00286

    Wernecke KEA, Vincenz D, Storsberg S, D'Hanis W, Goldschmidt J, Fendt M. 2015. Fox urine exposure induces avoidance behavior in rats and activates the amygdalar olfactory cortex. Behavioural Brain Research. 279:76-81. https://doi.org/10.1016/j.bbr.2014.11.020

    Kolodziej A, Lippert M, Angenstein F, Neubert J, Pethe A, Grosser OS, Amthauer H, Schroeder UH, Reymann KG, Scheich H, et al. 2014. SPECT-imaging of activity-dependent changes in regional cerebral blood flow induced by electrical and optogenetic self-stimulation in mice. NeuroImage. 103:171-180. https://doi.org/10.1016/j.neuroimage.2014.09.023

    Seidensticker M, Ulrich G, Muehlberg FL, Pethe A, Grosser OS, Steffen IG, Stiebler M, Goldschmidt J, Smalla KH, Seidensticker R, et al. 2014. Tumor cell uptake of 99mTc-Labeled 1-Thio-β-d-glucose and 5-thio-d-glucose in comparison with 2-deoxy-2-[18 f]fluoro-d-glucose in vitro: Kinetics, dependencies, blockage and cell compartment of accumulation. Molecular Imaging and Biology. 16(2):189-198. https://doi.org/10.1007/s11307-013-0690-3

    Lison H, Happel MFK, Schneider F, Baldauf K, Kerbstat S, Seelbinder B, Schneeberg J, Zappe M, Goldschmidt J, Budinger E, et al. 2014. Disrupted cross-laminar cortical processing in β amyloid pathology precedes cell death. Neurobiology of Disease. 63:62-73. https://doi.org/10.1016/j.nbd.2013.11.014

    Stöber F, Baldauf K, Ziabreva I, Harhausen D, Zille M, Neubert J, Reymann KG, Scheich H, Dirnagl U, Schröder UH, et al. 2014. Single-cell resolution mapping of neuronal damage in acute focal cerebral ischemia using thallium autometallography. Journal of Cerebral Blood Flow and Metabolism. 34(1):144-152. https://doi.org/10.1038/jcbfm.2013.177

    Wanger T, Takagaki K, Lippert MT, Goldschmidt J, Ohl FW. 2013. Wave propagation of cortical population activity under urethane anesthesia is state dependent. Neuroscience. 14:Article 78. https://doi.org/10.1186/1471-2202-14-78

    Apostolova I, Wunder A, Dirnagl U, Michel R, Stemmer N, Lukas M, Derlin T, Gregor-Mamoudou B, Goldschmidt J, Brenner W, et al. 2012. Brain perfusion SPECT in the mouse: Normal pattern according to gender and age. NeuroImage. 63(4):1807-1817. https://doi.org/10.1016/j.neuroimage.2012.08.038

    MacHaradze T, Pielot R, Wanger T, Scheich H, Gundelfinger ED, Budinger E, Goldschmidt J, Kreutz MR. 2012. Altered neuronal activity patterns in the visual cortex of the adult rat after partial optic nerve crush-a single-cell resolution metabolic mapping study. Cerebral Cortex. 22(8):1824-1833. https://doi.org/10.1093/cercor/bhr256

    Wanger T, Scheich H, Ohl FW, Goldschmidt J. 2012. The use of thallium diethyldithiocarbamate for mapping CNS potassium metabolism and neuronal activity: Tl +-redistribution, Tl +-kinetics and Tl +-equilibrium distribution. Journal of Neurochemistry. 122(1):106-114. https://doi.org/10.1111/j.1471-4159.2012.07757.x

    Lovell J, Brosch M, Budinger E, Goldschmidt J, Scheich H, Tschorn S, Wendt B, Zuschratter W. 2012. Scanning and Transmission Electron Microscope Examination of Cochlea Hair and Pillar Cells from the Ear of the Mongolian Gerbil (Meriones unguiculatus). Anatomy and Physiology. 2(3).

    Haroon F, Händel U, Angenstein F, Goldschmidt J, Kreutzmann P, Lison H, Fischer KD, Scheich H, Wetzel W, Schlüter D, et al. 2012. Toxoplasma gondii actively inhibits neuronal function in chronically infected mice. PLoS ONE. 7(4):e35516. https://doi.org/10.1371/journal.pone.0035516

    Schreiber S, Bueche CZ, Garz C, Kropf S, Angenstein F, Goldschmidt J, Neumann J, Heinze HJ, Goertler M, Reymann KG, et al. 2012. The pathologic cascade of cerebrovascular lesions in SHRSP: Is erythrocyte accumulation an early phase. Journal of Cerebral Blood Flow and Metabolism. 32(2):278-290. https://doi.org/10.1038/jcbfm.2011.122

    Coomber B, Edwards D, Jones SJ, Shackleton TM, Goldschmidt J, Wallace MN, Palmer AR. 2011. Cortical inactivation by cooling in small animals. Frontiers in Systems Neuroscience. 5(JUNE 2011):53. https://doi.org/10.3389/fnsys.2011.00053

    Heidt T, Deininger F, Peter K, Goldschmidt J, Pethe A, Hagemeyer CE, Neudorfer I, Zirlik A, Weber WA, Bode C, et al. 2011. Activated platelets in carotid artery thrombosis in mice can be selectively targeted with a radiolabeled single-chain antibody. PLoS ONE. 6(3):e18446. https://doi.org/10.1371/journal.pone.0018446

    Goldschmidt J, Wanger T, Engelhorn A, Friedrich H, Happel M, Ilango A, Engelmann M, Stuermer IW, Ohl FW, Scheich H. 2010. High-resolution mapping of neuronal activity using the lipophilic thallium chelate complex TlDDC: Protocol and validation of the method. NeuroImage. 49(1):303-315. https://doi.org/10.1016/j.neuroimage.2009.08.012

    Macharadze T, Goldschmidt J, Marunde M, Wanger T, Scheich H, Zuschratter W, Gundelfinger ED, Kreutz MR. 2009. Interretinal transduction of injury signals after unilateral optic nerve crush. NeuroReport. 20(3):301-305. https://doi.org/10.1097/WNR.0b013e32832027e6

    Goldschmidt J, Lison H, Scheich H. 2007. Single-cell resolution maps of potassium uptake in the rodent CNS - Implications for cerebral energy metabolism and functional neuroimaging. Journal of Cerebral Blood Flow and Metabolism. 27(SUPPL. 1).

    Angenstein F, Niessen HG, Goldschmidt J, Lison H, Altrock WD, Gundelfinger ED, Scheich H. 2007. Manganese-enhanced MRI reveals structural and functional changes in the cortex of bassoon mutant mice. Cerebral Cortex. 17(1):28-36. https://doi.org/10.1093/cercor/bhj121

    Deutscher A, Niessen HG, Angenstein F, Goldschmidt J, Scheich H, Schulze H. 2006. Comparison of estimates for volumes of brain ablations derived from structural MRI and classical histology. Journal of Neuroscience Methods. 156(1-2):136-139. https://doi.org/10.1016/j.jneumeth.2006.02.009

    Angenstein F, Niessen HG, Goldschmidt J, Vielhaber S, Ludolph AC, Scheich H. 2004. Age-dependent changes in MRI of motor brain stem nuclei in a mouse model of ALS. NeuroReport. 15(14):2271-2274. https://doi.org/10.1097/00001756-200410050-00026

    Goldschmidt J, Zuschratter W, Scheich H. 2004. High-resolution mapping of neuronal activity by thallium autometallography. NeuroImage. 23(2):638-647. https://doi.org/10.1016/j.neuroimage.2004.05.023
  • Drittmittel

    Drittmittel

    2022 - 2024 (WGL)
    Learning Resilience: Supporting neuronal network state transitions to foster stress resilience, Arbeitspaket 2 (self-balancing of cortical network states in stress recilience) und 3 (Brain-wide network state changes in cognitive flexibility behavioral fMRI)

    2012 - 2015 (LSA)
    2013: Odor-induced fear behavior in rodents - Identification and characterization of the underlying neural circuitry

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