LIN Personal

Prof. Dr. Magdalena Sauvage

Abteilungsleiterin

Funktionelle Architektur des Gedächtnisses

Leibniz-Institut für Neurobiologie
Brenneckestr. 6
39118 Magdeburg
Deutschland
Telefon: +49 391 6263 94011
E-Mail: Magdalena.Sauvage@lin-magdeburg.de
ORCID: 0000-0002-7586-6410

  • Publikationen

    Publikationen

    Grande X, Sauvage M, Becke A, Düzel E, Berron D. 2021. Functional connectivity and information pathways in the human entorhinal-hippocampal circuitry. (bioRxiv). https://doi.org/10.1101/2021.12.17.473123

    Crittenden JR, Zhai S, Sauvage M, Kitsukawa T, Burguière E, Thomsen M, Zhang H, Costa C, Martella G, Ghiglieri V, Picconi B, Pescatore KA, Unterwald EM, Jackson WS, Housman DE, Caine SB, Sulzer D, Calabresi P, Smith AC, Surmeier DJ, Graybiel AM. 2021. CalDAG-GEFI mediates striatal cholinergic modulation of dendritic excitability, synaptic plasticity and psychomotor behaviors. Neurobiology of Disease. 158:Article 105473. https://doi.org/10.1016/j.nbd.2021.105473

    Mahnke L, Atucha E, Pina-Fernàndez E, Kitsukawa T, Sauvage MM. 2021. Lesion of the hippocampus selectively enhances LEC's activity during recognition memory based on familiarity. Scientific Reports. 11(1):Article 19085. https://doi.org/10.1038/s41598-021-98509-4

    Oulé M, Atucha E, Wells TM, Macharadze T, Sauvage MM, Kreutz MR, Lopez-Rojas J. 2021. Dendritic Kv4.2 potassium channels selectively mediate spatial pattern separation in the dentate gyrus. iScience. 24(8):102876. https://doi.org/10.1016/j.isci.2021.102876

    Atucha E, Ku S-P, Lippert M, Sauvage M. 2021. Remembering the gist of an event over a lifetime depends on the hippocampus. bioRxiv. https://doi.org/10.1101/2021.04.14.439803

    Valero-Aracama MJ, Reboreda A, Arboit A, Sauvage M, Yoshida M. 2021. Noradrenergic suppression of persistent firing in hippocampal CA1 pyramidal cells through cAMP-PKA pathway. eNeuro. 8(2):1-12. https://doi.org/10.1523/ENEURO.0440-20.2020

    Mahnke L, Atucha E, Kitsukawa T, Sauvage MM. 2020. Recognition memory: familiarity signals increase selectively in the lateral entorhinal cortex following hippocampal lesions. bioRxiv. https://doi.org/10.1101/2020.06.16.131763

    Kessler H, Schmidt AC, James EL, Blackwell SE, von Rauchhaupt M, Harren K, Kehyayan A, Clark IA, Sauvage M, Herpertz S, Axmacher N, Holmes EA. 2020. Visuospatial computer game play after memory reminder delivered three days after a traumatic film reduces the number of intrusive memories of the experimental trauma. Journal of Behavior Therapy and Experimental Psychiatry. 67:Article 101454. https://doi.org/10.1016/j.jbtep.2019.01.006

    Sauvage M, Kitsukawa T, Atucha E. 2019. Single-cell memory trace imaging with immediate-early genes. Journal of Neuroscience Methods. 326:108368. https://doi.org/10.1016/j.jneumeth.2019.108368

    Crittenden JR, Sauvage M, Kitsukawa T, Burguière E, Cepeda C, André VM, Canault M, Thomsen M, Zhang H, Costa C, Martella G, Ghiglieri V, Pescatore KA, Unterwald EM, Jackson W, Housman DE, Caine SB, Sulzer D, Calabresi P, Levine MS, Brefel-Courbon C, Smith AC, Alessi M-C, Azulay J-P, Graybiel AM. 2019. Mutations in CalDAG-GEFI Lead to Striatal Signaling Deficits and Psychomotor Symptoms in Multiple Species Including Human. bioRxiv. https://doi.org/10.1101/709246

    Flasbeck V, Atucha E, Nakamura NH, Yoshida M, Sauvage MM. 2018. Spatial information is preferentially processed by the distal part of CA3: implication for memory retrieval. Behavioural Brain Research. 354:31-38. https://doi.org/10.1016/j.bbr.2018.07.023

    Beer Z, Vavra P, Atucha E, Rentzing K, Heinze HJ, Sauvage MM. 2018. The memory for time and space differentially engages the proximal and distal parts of the hippocampal subfields CA1 and CA3. PLoS Biology. 16(8):e2006100. https://doi.org/10.1371/journal.pbio.2006100

    Berron D, Neumann K, Maass A, Schütze H, Fliessbach K, Kiven V, Jessen F, Sauvage M, Kumaran D, Düzel E. 2018. Age-related functional changes in domain-specific medial temporal lobe pathways. Neurobiology of Aging. 65:86-97. https://doi.org/10.1016/j.neurobiolaging.2017.12.030

    Behroozi M, Chwiesko C, Ströckens F, Sauvage M, Helluy X, Peterburs J, Güntürkün O. 2018. In vivo measurement of T1 and T2 relaxation times in awake pigeon and rat brains at 7T. Magnetic Resonance in Medicine. 79(2):1090-1100. https://doi.org/10.1002/mrm.26722

    Atucha E, Karew A, Kitsukawa T, Sauvage MM. 2017. Recognition memory: Cellular evidence of a massive contribution of the LEC to familiarity and a lack of involvement of the hippocampal subfields CA1 and CA3. Hippocampus. 27(10):1083-1092. https://doi.org/10.1002/hipo.22754

    Ku SP, Nakamura NH, Maingret N, Mahnke L, Yoshida M, Sauvage MM. 2017. Regional specific evidence for memory-load dependent activity in the dorsal subiculum and the lateral entorhinal cortex. Frontiers in Systems Neuroscience. 11:Article 51. https://doi.org/10.3389/fnsys.2017.00051

    Lux V, Masseck OA, Herlitze S, Sauvage MM. 2017. Optogenetic Destabilization of the Memory Trace in CA1: Insights into Reconsolidation and Retrieval Processes. Cerebral Cortex. 27(1):841-851. https://doi.org/10.1093/cercor/bhv282

    Trossbach SV, Bader V, Hecher L, Pum ME, Masoud ST, Prikulis I, Schäble S, de Souza Silva MA, Su P, Boulat B, Chwiesko C, Poschmann G, Stühler K, Lohr KM, Stout KA, Oskamp A, Godsave SF, Müller-Schiffmann A, Bilzer T, Steiner H, Peters PJ, Bauer A, Sauvage M, Ramsey AJ, Miller GW, Liu F, Seeman P, Brandon NJ, Huston JP, Korth C. 2016. Misassembly of full-length Disrupted-in-Schizophrenia 1 protein is linked to altered dopamine homeostasis and behavioral deficits. Molecular Psychiatry. 21(11):1561-1572. https://doi.org/10.1038/mp.2015.194

    Hamburg H, Trossbach SV, Bader V, Chwiesko C, Kipar A, Sauvage M, Crum WR, Vernon AC, Bidmon HJ, Korth C. 2016. Simultaneous effects on parvalbumin-positive interneuron and dopaminergic system development in a transgenic rat model for sporadic schizophrenia. Scientific Reports. 6:Article 34946. https://doi.org/10.1038/srep34946

    Lux V, Atucha Trevino E, Kitsukawa T, Sauvage MM. 2016. Imaging a memory trace over half a life-time in the medial temporal lobe reveals a time-limited role of CA3 neurons in retrieval. eLife. 5(FEBRUARY2016):Article e11862. https://doi.org/10.7554/eLife.11862

    Nakamura NH, Sauvage MM. 2016. Encoding and reactivation patterns predictive of successful memory performance are topographically organized along the longitudinal axis of the hippocampus. Hippocampus. 26(1):67-75. https://doi.org/10.1002/hipo.22491

    Valero-Aracama MJ, Sauvage MM, Yoshida M. 2015. Environmental enrichment modulates intrinsic cellular excitability of hippocampal CA1 pyramidal cells in a housing duration and anatomical location-dependent manner. Behavioural Brain Research. 292:209-218. https://doi.org/10.1016/j.bbr.2015.05.032

    Kabanova A, Pabst M, Lorkowski M, Braganza O, Boehlen A, Nikbakht N, Pothmann L, Vaswani AR, Musgrove R, Di Monte DA, Sauvage M, Beck H, Blaess S. 2015. Function and developmental origin of a mesocortical inhibitory circuit. Nature Neuroscience. 18(6):872-882. https://doi.org/10.1038/nn.4020

    Herold C, Bingman VP, Ströckens F, Letzner S, Sauvage M, Palomero-Gallagher N, Zilles K, Güntürkün O. 2014. Distribution of neurotransmitter receptors and zinc in the pigeon (Columba livia) hippocampal formation: A basis for further comparison with the mammalian hippocampus. Journal of Comparative Neurology. 522(11):2553-2575. https://doi.org/10.1002/cne.23549

    Wiemers US, Sauvage MM, Wolf OT. 2014. Odors as effective retrieval cues for stressful episodes. Neurobiology of Learning and Memory. 112:230-236. https://doi.org/10.1016/j.nlm.2013.10.004

    Beer Z, Chwiesko C, Sauvage MM. 2014. Processing of spatial and non-spatial information reveals functional homogeneity along the dorso-ventral axis of CA3, but not CA1. Neurobiology of Learning and Memory. 111:56-64. https://doi.org/10.1016/j.nlm.2014.03.001

    Beer Z, Chwiesko C, Kitsukawa T, Sauvage MM. 2013. Spatial and stimulus-type tuning in the LEC, MEC, POR, PrC, CA1, and CA3 during spontaneous item recognition memory. Hippocampus. 23(12):1425-1438. https://doi.org/10.1002/hipo.22195

    Sauvage MM, Nakamura NH, Beer Z. 2013. Mapping memory function in the medial temporal lobe with the immediate-early gene Arc. Behavioural Brain Research. 254:22-33. https://doi.org/10.1016/j.bbr.2013.04.048

    Wiemers US, Sauvage MM, Schoofs D, Hamacher-Dang TC, Wolf OT. 2013. What we remember from a stressful episode. Psychoneuroendocrinology. 38(10):2268-2277. https://doi.org/10.1016/j.psyneuen.2013.04.015

    Nakamura NH, Flasbeck V, Maingret N, Kitsukawa T, Sauvage MM. 2013. Proximodistal segregation of nonspatial information in CA3: Preferential recruitment of a proximal CA3-distal CA1 network in nonspatial recognition memory. Journal of Neuroscience. 33(28):11506-11514. https://doi.org/10.1523/JNEUROSCI.4480-12.2013

    Eichenbaum H, Sauvage M, Fortin N, Robitsek J, Komorowski R. 2012. A Comparative Analysis of Episodic Memory: Cognitive Mechanisms and Neural Substrates. In The Oxford Handbook of Comparative Cognition. Oxford University Press. https://doi.org/10.1093/oxfordhb/9780195392661.013.0017

    Eichenbaum H, Sauvage M, Fortin N, Komorowski R, Lipton P. 2012. Towards a functional organization of episodic memory in the medial temporal lobe. Neuroscience and Biobehavioral Reviews. 36(7):1597-1608. https://doi.org/10.1016/j.neubiorev.2011.07.006

    Place R, Lykken C, Beer Z, Suh J, McHugh TJ, Tonegawa S, Eichenbaum H, Sauvage MM. 2012. NMDA signaling in CA1 mediates selectively the spatial component of episodic memory. Learning and Memory. 19(4):164-169. https://doi.org/10.1101/lm.025254.111

    Sauvage MM. 2012. Neural substrates of recollection and familiarity: Further bridging human and animal recognition memory using translational paradigms. In Psychology of Memory. Nova Science Publishers, Inc. pp. 155-182.

    Sauvage MM, Beer Z, Ekovich M, Ho L, Eichenbaum H. 2010. The caudal medial entorhinal cortex: A selective role in recollection-based recognition memory. Journal of Neuroscience. 30(46):15695-15699. https://doi.org/10.1523/JNEUROSCI.4301-10.2010

    Sauvage MM. 2010. ROC in animals: Uncovering the neural substrates of recollection and familiarity in episodic recognition memory. Consciousness and Cognition. 19(3):816-828. https://doi.org/10.1016/j.concog.2010.06.023

    Eichenbaum H, Fortin N, Sauvage M, Robitsek RJ, Farovik A. 2010. An animal model of amnesia that uses Receiver Operating Characteristics (ROC) analysis to distinguish recollection from familiarity deficits in recognition memory. Neuropsychologia. 48(8):2281-2289. https://doi.org/10.1016/j.neuropsychologia.2009.09.015

    Sauvage MM, Beer Z, Eichenbaum H. 2010. Recognition memory: Adding a response deadline eliminates recollection but spares familiarity. Learning and Memory. 17(2):104-108. https://doi.org/10.1101/lm.1647710

    DeVito LM, Konigsberg R, Lykken C, Sauvage M, Young WS, Eichenbaum H. 2009. Vasopressin 1b receptor knock-out impairs memory for temporal order. Journal of Neuroscience. 29(9):2676-2683. https://doi.org/10.1523/JNEUROSCI.5488-08.2009

    Eichenbaum H, Sauvage MM, Fortin NJ, Yonelinas AP. 2008. ROCs in rats? Response to wixted and squire. Learning and Memory. 15(9):691-693. https://doi.org/10.1101/lm.1133808

    Sauvage MM, Fortin NJ, Owens CB, Yonelinas AP, Eichenbaum H. 2008. Recognition memory: Opposite effects of hippocampal damage on recollection and familiarity. Nature Neuroscience. 11(1):16-18. https://doi.org/10.1038/nn2016

    Sauvage M, Steckler T. 2001. Detection of corticotropin-releasing hormone receptor 1 immunoreactivity in cholinergic, dopaminergic and noradrenergic neurons of the murine basal forebrain and brainstem nuclei - Potential implication for arousal and attention. Neuroscience. 104(3):643-652. https://doi.org/10.1016/S0306-4522(01)00137-3

    Steckler T, Rammes G, Sauvage M, Van Gaalen MM, Weis C, Zieglgänsberger W, Holsboer F. 2001. Effects of the monoamine oxidase A inhibitor moclobemide on hippocampal plasticity in GR-impaired transgenic mice. Journal of Psychiatric Research. 35(1):29-42. https://doi.org/10.1016/S0022-3956(00)00040-6

    Sauvage M, Brabet P, Holsboer F, Bockaert J, Steckler T. 2000. Mild deficits in mice lacking pituitary adenylate cyclase-activating polypeptide receptor type 1 (PAC1) performing on memory tasks. Molecular Brain Research. 84(1-2):79-89. https://doi.org/10.1016/S0169-328X(00)00219-9

    Steckler T, Sauvage M, Holsboer F. 2000. Glucocorticoid receptor impairment enhances impulsive responding in transgenic mice performing on a simultaneous visual discrimination task. In European Journal of Neuroscience. 7 ed. pp. 2559-2569. (The European journal of neuroscience). https://doi.org/10.1046/j.1460-9568.2000.00111.x

    Arns M, Sauvage M, Steckler T. 1999. Excitotoxic hippocampal lesions disrupt allocentric spatial learning in mice: Effects of strain and task demands. Behavioural Brain Research. 106(1-2):151-164. https://doi.org/10.1016/S0166-4328(99)00103-5

    Steckler T, Weis C, Sauvage M, Mederer A, Holsboer F. 1999. Disrupted allocentric but preserved egocentric spatial learning in transgenic mice with impaired glucocorticoid receptor function. Behavioural Brain Research. 100(1-2):77-89. https://doi.org/10.1016/S0166-4328(98)00115-6

    Doutrelant-Viltart O, Sauvage M, Sequeira H. 1997. Expression of c-fos in bulbar nuclei involved in cardiovascular control following the electrical stimulation of sensorimotor cortex in the rat. Neuroscience Letters. 227(2):71-74. https://doi.org/10.1016/S0304-3940(97)00306-6
  • Drittmittel

    Drittmittel

    2020 - 2024 (DFG)
    SFB 1436 TP B01: Konnektivität des medialen Temporallappens und des präfrontalen Kortex als neurale Ressource des Erkennungsgedächtnisses zur Wiedererkennung
    https://sfb1436.de/

    2021 - 2024 (DFG)
    "Der Beitrag der Hippocampusregionen CA1, CA2, der temporo-ammonischen und trisynaptischen Signalwege zum Abruf von Gedächtnis über eine halbe Lebensspanne"

    2017 - 2019 (DFG)
    SFB 779/ TP B17: Die Verarbeitung räumlicher und nicht-räumlicher Information bei motiviertem Erinnern
    http://www.sfb779.de/

    2019 - 2019 (DFG)
    Räumliche und nicht-räumliche "hippocampale" Teilnetzwerke: Beitrag des Subiculum?

    2016 - 2018 (DFG)
    SFB 874/ TP B09: Sensorische Informationsverarbeitung im medialen Temporallappen bei Gedächtnisabruf

    2018 - 2018 (LSA)
    Functional Architecture of Memory, 23.-25.05.2018 in Magdeburg

    2016 - 2016 (DFG)
    Internat. wissenschaftliche Veranstaltung: "Third International Functional Architecture of Memory Conference"

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