LIN Personal

Prof. Dr. Magdalena Sauvage


Funktionelle Architektur des Gedächtnisses

Leibniz-Institut für Neurobiologie
Brenneckestr. 6
39118 Magdeburg
Telefon: +49 391 6263 94011
ORCID: 0000-0002-7586-6410

  • Publikationen


    Ku S-P, Atucha E, Alavi N, Mulla-Osman H, Kayumova R, Yoshida M, Csicsvari J, Sauvage MM. 2024. Phase locking of hippocampal CA3 neurons to distal CA1 theta oscillations selectively predicts memory performance. Cell Reports. 43(6):Article 114276.

    Atucha E, Ku S-P, Lippert MT, Sauvage MM. 2023. Recalling gist memory depends on CA1 hippocampal neurons for lifetime retention and CA3 neurons for memory precision. Cell Reports. 42(11):Article 113317.

    Schott BH, Soch J, Kizilirmak JM, Schütze H, Assmann A, Maass A, Ziegler G, Sauvage M, Richter A. 2023. Inhibitory temporo-parietal effective connectivity is associated with explicit memory performance in older adults. iScience. 26(10):Article 107765.

    Saber Marouf B, Reboreda A, Theissen F, Kaushik R, Sauvage M, Dityatev A, Yoshida M. 2023. TRPC4 Channel Knockdown in the Hippocampal CA1 Region Impairs Modulation of Beta Oscillations in Novel Context. Biology. 12(4):Article 629.

    Brahimi Y, Knauer B, Price AT, Valero Aracama MJ, Reboreda A, Sauvage M, Yoshida M. 2023. Persistent Firing in Hippocampal CA1 Pyramidal Cells in Young and Aged Rats. eNeuro. 10(3):Article ENEURO.0479-22.2023.

    Grande X, Sauvage MM, Becke A, Düzel E, Berron D. 2022. Transversal functional connectivity and scene-specific processing in the human entorhinal-hippocampal circuitry. eLife. 11:Article e76479.

    Grande X, Sauvage M, Becke A, Düzel E, Berron D. 2021. Functional connectivity and information pathways in the human entorhinal-hippocampal circuitry. bioRxiv.

    Crittenden JR, Zhai S, Sauvage M, Kitsukawa T, Burguière E, Thomsen M, Zhang H, Costa C, Martella G, Ghiglieri V, et al. 2021. CalDAG-GEFI mediates striatal cholinergic modulation of dendritic excitability, synaptic plasticity and psychomotor behaviors. Neurobiology of Disease. 158:Article 105473.

    Mahnke L, Atucha E, Pina-Fernàndez E, Kitsukawa T, Sauvage MM. 2021. Lesion of the hippocampus selectively enhances LEC's activity during recognition memory based on familiarity. Scientific Reports. 11(1):Article 19085.

    Oulé M, Atucha E, Wells TM, Macharadze T, Sauvage MM, Kreutz MR, Lopez-Rojas J. 2021. Dendritic Kv4.2 potassium channels selectively mediate spatial pattern separation in the dentate gyrus. iScience. 24(8):102876.

    Atucha E, Ku S-P, Lippert M, Sauvage M. 2021. Remembering the gist of an event over a lifetime depends on the hippocampus. bioRxiv.

    Valero-Aracama MJ, Reboreda A, Arboit A, Sauvage M, Yoshida M. 2021. Noradrenergic suppression of persistent firing in hippocampal CA1 pyramidal cells through cAMP-PKA pathway. eNeuro. 8(2):1-12.

    Mahnke L, Atucha E, Kitsukawa T, Sauvage MM. 2020. Recognition memory: familiarity signals increase selectively in the lateral entorhinal cortex following hippocampal lesions. bioRxiv.

    Kessler H, Schmidt AC, James EL, Blackwell SE, von Rauchhaupt M, Harren K, Kehyayan A, Clark IA, Sauvage M, Herpertz S, et al. 2020. Visuospatial computer game play after memory reminder delivered three days after a traumatic film reduces the number of intrusive memories of the experimental trauma. Journal of Behavior Therapy and Experimental Psychiatry. 67:Article 101454.

    Sauvage M, Kitsukawa T, Atucha E. 2019. Single-cell memory trace imaging with immediate-early genes. Journal of Neuroscience Methods. 326:108368.

    Crittenden JR, Sauvage M, Kitsukawa T, Burguière E, Cepeda C, André VM, Canault M, Thomsen M, Zhang H, Costa C, et al. 2019. Mutations in CalDAG-GEFI Lead to Striatal Signaling Deficits and Psychomotor Symptoms in Multiple Species Including Human. bioRxiv.

    Flasbeck V, Atucha E, Nakamura NH, Yoshida M, Sauvage MM. 2018. Spatial information is preferentially processed by the distal part of CA3: implication for memory retrieval. Behavioural Brain Research. 347:116-123.

    Beer Z, Vavra P, Atucha E, Rentzing K, Heinze HJ, Sauvage MM. 2018. The memory for time and space differentially engages the proximal and distal parts of the hippocampal subfields CA1 and CA3. PLoS Biology. 16(8):e2006100.

    Berron D, Neumann K, Maass A, Schütze H, Fliessbach K, Kiven V, Jessen F, Sauvage M, Kumaran D, Düzel E. 2018. Age-related functional changes in domain-specific medial temporal lobe pathways. Neurobiology of Aging. 65:86-97.

    Behroozi M, Chwiesko C, Ströckens F, Sauvage M, Helluy X, Peterburs J, Güntürkün O. 2018. In vivo measurement of T1 and T2 relaxation times in awake pigeon and rat brains at 7T. Magnetic Resonance in Medicine. 79(2):1090-1100.

    Atucha E, Karew A, Kitsukawa T, Sauvage MM. 2017. Recognition memory: Cellular evidence of a massive contribution of the LEC to familiarity and a lack of involvement of the hippocampal subfields CA1 and CA3. Hippocampus. 27(10):1083-1092.

    Ku SP, Nakamura NH, Maingret N, Mahnke L, Yoshida M, Sauvage MM. 2017. Regional specific evidence for memory-load dependent activity in the dorsal subiculum and the lateral entorhinal cortex. Frontiers in Systems Neuroscience. 11:Article 51.

    Lux V, Masseck OA, Herlitze S, Sauvage MM. 2017. Optogenetic Destabilization of the Memory Trace in CA1: Insights into Reconsolidation and Retrieval Processes. Cerebral Cortex. 27(1):841-851.

    Trossbach SV, Bader V, Hecher L, Pum ME, Masoud ST, Prikulis I, Schäble S, de Souza Silva MA, Su P, Boulat B, et al. 2016. Misassembly of full-length Disrupted-in-Schizophrenia 1 protein is linked to altered dopamine homeostasis and behavioral deficits. Molecular Psychiatry. 21(11):1561-1572.

    Hamburg H, Trossbach SV, Bader V, Chwiesko C, Kipar A, Sauvage M, Crum WR, Vernon AC, Bidmon HJ, Korth C. 2016. Simultaneous effects on parvalbumin-positive interneuron and dopaminergic system development in a transgenic rat model for sporadic schizophrenia. Scientific Reports. 6:Article 34946.

    Lux V, Atucha Trevino E, Kitsukawa T, Sauvage MM. 2016. Imaging a memory trace over half a life-time in the medial temporal lobe reveals a time-limited role of CA3 neurons in retrieval. eLife. 5(FEBRUARY2016):Article e11862.

    Nakamura NH, Sauvage MM. 2016. Encoding and reactivation patterns predictive of successful memory performance are topographically organized along the longitudinal axis of the hippocampus. Hippocampus. 26(1):67-75.

    Valero-Aracama MJ, Sauvage MM, Yoshida M. 2015. Environmental enrichment modulates intrinsic cellular excitability of hippocampal CA1 pyramidal cells in a housing duration and anatomical location-dependent manner. Behavioural Brain Research. 292:209-218.

    Kabanova A, Pabst M, Lorkowski M, Braganza O, Boehlen A, Nikbakht N, Pothmann L, Vaswani AR, Musgrove R, Di Monte DA, et al. 2015. Function and developmental origin of a mesocortical inhibitory circuit. Nature Neuroscience. 18(6):872-882.

    Herold C, Bingman VP, Ströckens F, Letzner S, Sauvage M, Palomero-Gallagher N, Zilles K, Güntürkün O. 2014. Distribution of neurotransmitter receptors and zinc in the pigeon (Columba livia) hippocampal formation: A basis for further comparison with the mammalian hippocampus. Journal of Comparative Neurology. 522(11):2553-2575.

    Wiemers US, Sauvage MM, Wolf OT. 2014. Odors as effective retrieval cues for stressful episodes. Neurobiology of Learning and Memory. 112:230-236.

    Beer Z, Chwiesko C, Sauvage MM. 2014. Processing of spatial and non-spatial information reveals functional homogeneity along the dorso-ventral axis of CA3, but not CA1. Neurobiology of Learning and Memory. 111:56-64.

    Beer Z, Chwiesko C, Kitsukawa T, Sauvage MM. 2013. Spatial and stimulus-type tuning in the LEC, MEC, POR, PrC, CA1, and CA3 during spontaneous item recognition memory. Hippocampus. 23(12):1425-1438.

    Sauvage MM, Nakamura NH, Beer Z. 2013. Mapping memory function in the medial temporal lobe with the immediate-early gene Arc. Behavioural Brain Research. 254:22-33.

    Wiemers US, Sauvage MM, Schoofs D, Hamacher-Dang TC, Wolf OT. 2013. What we remember from a stressful episode. Psychoneuroendocrinology. 38(10):2268-2277.

    Nakamura NH, Flasbeck V, Maingret N, Kitsukawa T, Sauvage MM. 2013. Proximodistal segregation of nonspatial information in CA3: Preferential recruitment of a proximal CA3-distal CA1 network in nonspatial recognition memory. Journal of Neuroscience. 33(28):11506-11514.

    Eichenbaum H, Sauvage M, Fortin N, Robitsek J, Komorowski R. 2012. A Comparative Analysis of Episodic Memory: Cognitive Mechanisms and Neural Substrates. In The Oxford Handbook of Comparative Cognition. Oxford University Press.

    Eichenbaum H, Sauvage M, Fortin N, Komorowski R, Lipton P. 2012. Towards a functional organization of episodic memory in the medial temporal lobe. Neuroscience and Biobehavioral Reviews. 36(7):1597-1608.

    Place R, Lykken C, Beer Z, Suh J, McHugh TJ, Tonegawa S, Eichenbaum H, Sauvage MM. 2012. NMDA signaling in CA1 mediates selectively the spatial component of episodic memory. Learning and Memory. 19(4):164-169.

    Sauvage MM. 2012. Neural substrates of recollection and familiarity: Further bridging human and animal recognition memory using translational paradigms. In Psychology of Memory. Nova Science Publishers, Inc. pp. 155-182.

    Sauvage MM, Beer Z, Ekovich M, Ho L, Eichenbaum H. 2010. The caudal medial entorhinal cortex: A selective role in recollection-based recognition memory. Journal of Neuroscience. 30(46):15695-15699.

    Sauvage MM. 2010. ROC in animals: Uncovering the neural substrates of recollection and familiarity in episodic recognition memory. Consciousness and Cognition. 19(3):816-828.

    Eichenbaum H, Fortin N, Sauvage M, Robitsek RJ, Farovik A. 2010. An animal model of amnesia that uses Receiver Operating Characteristics (ROC) analysis to distinguish recollection from familiarity deficits in recognition memory. Neuropsychologia. 48(8):2281-2289.

    Sauvage MM, Beer Z, Eichenbaum H. 2010. Recognition memory: Adding a response deadline eliminates recollection but spares familiarity. Learning and Memory. 17(2):104-108.

    DeVito LM, Konigsberg R, Lykken C, Sauvage M, Young WS, Eichenbaum H. 2009. Vasopressin 1b receptor knock-out impairs memory for temporal order. Journal of Neuroscience. 29(9):2676-2683.

    Eichenbaum H, Sauvage MM, Fortin NJ, Yonelinas AP. 2008. ROCs in rats? Response to wixted and squire. Learning and Memory. 15(9):691-693.

    Sauvage MM, Fortin NJ, Owens CB, Yonelinas AP, Eichenbaum H. 2008. Recognition memory: Opposite effects of hippocampal damage on recollection and familiarity. Nature Neuroscience. 11(1):16-18.

    Sauvage M, Steckler T. 2001. Detection of corticotropin-releasing hormone receptor 1 immunoreactivity in cholinergic, dopaminergic and noradrenergic neurons of the murine basal forebrain and brainstem nuclei - Potential implication for arousal and attention. Neuroscience. 104(3):643-652.

    Steckler T, Rammes G, Sauvage M, Van Gaalen MM, Weis C, Zieglgänsberger W, Holsboer F. 2001. Effects of the monoamine oxidase A inhibitor moclobemide on hippocampal plasticity in GR-impaired transgenic mice. Journal of Psychiatric Research. 35(1):29-42.

    Sauvage M, Brabet P, Holsboer F, Bockaert J, Steckler T. 2000. Mild deficits in mice lacking pituitary adenylate cyclase-activating polypeptide receptor type 1 (PAC1) performing on memory tasks. Molecular Brain Research. 84(1-2):79-89.

    Steckler T, Sauvage M, Holsboer F. 2000. Glucocorticoid receptor impairment enhances impulsive responding in transgenic mice performing on a simultaneous visual discrimination task. In European Journal of Neuroscience. 7 ed. pp. 2559-2569. (The European journal of neuroscience).

    Arns M, Sauvage M, Steckler T. 1999. Excitotoxic hippocampal lesions disrupt allocentric spatial learning in mice: Effects of strain and task demands. Behavioural Brain Research. 106(1-2):151-164.

    Steckler T, Weis C, Sauvage M, Mederer A, Holsboer F. 1999. Disrupted allocentric but preserved egocentric spatial learning in transgenic mice with impaired glucocorticoid receptor function. Behavioural Brain Research. 100(1-2):77-89.

    Doutrelant-Viltart O, Sauvage M, Sequeira H. 1997. Expression of c-fos in bulbar nuclei involved in cardiovascular control following the electrical stimulation of sensorimotor cortex in the rat. Neuroscience Letters. 227(2):71-74.
  • Drittmittel


    2021 - 2025 (DFG)
    "Der Beitrag der Hippocampusregionen CA1, CA2, der temporo-ammonischen und trisynaptischen Signalwege zum Abruf von Gedächtnis über eine halbe Lebensspanne"

    2023 - 2025 (Bund)
    DZPG Aufbauförderung - "Standort Jena" - Physiologie und Pathophysiologie neuronaler Schaltkreise im Kontext psychischer Gesundheit

    2020 - 2024 (DFG)
    SFB 1436 TP B01: Konnektivität des medialen Temporallappens und des präfrontalen Kortex als neurale Ressource des Erkennungsgedächtnisses zur Wiedererkennung

    2024 - 2024 (DFG)
    Internationale wissenschaftliche Veranstaltung: „Internationale und speziesübergreifende Konferenz "Funktionelle Architektur des Gedächtnisses (FAM)"

    2022 - 2022 (DFG)
    Internationale wissenschaftliche Veranstaltun: "5. Internationale Konferenz zur funktionellen Architektur des Gedächtnisses FAM", in Magdeburg

    2017 - 2019 (DFG)
    SFB 779/ TP B17: Die Verarbeitung räumlicher und nicht-räumlicher Information bei motiviertem Erinnern

    2019 - 2019 (DFG)
    Räumliche und nicht-räumliche "hippocampale" Teilnetzwerke: Beitrag des Subiculum?

    2016 - 2018 (DFG)
    SFB 874/ TP B09: Sensorische Informationsverarbeitung im medialen Temporallappen bei Gedächtnisabruf

    2018 - 2018 (LSA)
    Functional Architecture of Memory, 23.-25.05.2018 in Magdeburg

    2016 - 2016 (DFG)
    Internat. wissenschaftliche Veranstaltung: "Third International Functional Architecture of Memory Conference"

Diese Seite teilen: