LIN Personal

Prof. Dr. Stefan Remy

Wissenschaftlicher Direktor

Zelluläre Neurowissenschaften

Leibniz-Institut für Neurobiologie
Brenneckestr. 6
39118 Magdeburg
Deutschland
Telefon: +49 391 6263 92421
E-Mail: Stefan.Remy@lin-magdeburg.de

  • Publikationen

    Publikationen

    Sosulina L, Mittag M, Geis H-R, Hoffmann K, Klyubin I, Qi Y, Steffen J, Friedrichs D, Henneberg N, Fuhrmann F, Justus D, Keppler K, Cuello AC, Rowan MJ, Fuhrmann M, Remy S. 2021. Hippocampal hyperactivity in a rat model of Alzheimer's disease. Journal of Neurochemistry. 157(6):2128-2144. https://doi.org/10.1111/jnc.15323

    Korvasová K, Ludwig F, Kaneko H, Sosulina L, Tetzlaff T, Remy S, Mikulovic S. 2021. Locomotion induced by medial septal glutamatergic neurons is linked to intrinsically generated persistent firing. bioRxiv. https://doi.org/10.1101/2021.04.23.441122

    Bertan F, Wischhof L, Sosulina L, Mittag M, Dalügge D, Fornarelli A, Gardoni F, Marcello E, Di Luca M, Fuhrmann M, Remy S, Bano D, Nicotera P. 2020. Loss of Ryanodine Receptor 2 impairs neuronal activity-dependent remodeling of dendritic spines and triggers compensatory neuronal hyperexcitability. Cell Death and Differentiation. 27(12):3354-3373. https://doi.org/10.1038/s41418-020-0584-2

    Schwarz MK, Remy S. 2019. Rabies virus-mediated connectivity tracing from single neurons. Journal of Neuroscience Methods. 325:108365. https://doi.org/10.1016/j.jneumeth.2019.108365

    Dalügge D, Remy S. 2018. Human Cortical Dendrites: Stretched to Perform Better?. Cell. 175(3):635-637. https://doi.org/10.1016/j.cell.2018.09.052

    Musial TF, Molina-Campos E, Bean LA, Ybarra N, Borenstein R, Russo ML, Buss EW, Justus D, Neuman KM, Ayala GD, Mullen SA, Voskobiynyk Y, Tulisiak CT, Fels JA, Corbett NJ, Carballo G, Kennedy CD, Popovic J, Ramos-Franco J, Fill M, Pergande MR, Borgia JA, Corbett GT, Pahan K, Han Y, Chetkovich DM, Vassar RJ, Byrne RW, Matthew Oh M, Stoub TR, Remy S, Disterhoft JF, Nicholson DA. 2018. Store depletion-induced h-channel plasticity rescues a channelopathy linked to Alzheimer's disease. Neurobiology of Learning and Memory. 154:141-157. https://doi.org/10.1016/j.nlm.2018.06.004

    Müller C, Remy S. 2018. Septo–hippocampal interaction. Cell and Tissue Research. 373(3):565-575. https://doi.org/10.1007/s00441-017-2745-2

    Müller C, Geis HR, Remy S. 2018. Visually Guided Single-Cell Recordings in the Hippocampus of Awake Mice. Manahan-Vaughan D, editor. In Handbook of in Vivo Neural Plasticity Techniques. Elsevier B.V. pp. 123-134. (Handbook of Behavioral Neuroscience). https://doi.org/10.1016/B978-0-12-812028-6.00006-9

    Remy S, Poirazi P, Papoutsi A. 2017. Introduction to the Computational Neuroscience Special Section. European Journal of Neuroscience. 45(8):998-999. https://doi.org/10.1111/ejn.13562

    Justus D, Dalügge D, Bothe S, Fuhrmann F, Hannes C, Kaneko H, Friedrichs D, Sosulina L, Schwarz I, Elliott DA, Schoch S, Bradke F, Schwarz MK, Remy S. 2017. Glutamatergic synaptic integration of locomotion speed via septoentorhinal projections. Nature Neuroscience. 20(1):16-19. https://doi.org/10.1038/nn.4447

    Schmid LC, Mittag M, Poll S, Steffen J, Wagner J, Geis HR, Schwarz I, Schmidt B, Schwarz MK, Remy S, Fuhrmann M. 2016. Dysfunction of Somatostatin-Positive Interneurons Associated with Memory Deficits in an Alzheimer's Disease Model. Neuron. 92(1):114-125. https://doi.org/10.1016/j.neuron.2016.08.034

    Müller C, Remy S. 2016. Slowly Building Excitement. Cell. 165(7):1568-1569. https://doi.org/10.1016/j.cell.2016.06.005

    Wagner J, Krauss S, Shi S, Ryazanov S, Steffen J, Miklitz C, Leonov A, Kleinknecht A, Göricke B, Weishaupt JH, Weckbecker D, Reiner AM, Zinth W, Levin J, Ehninger D, Remy S, Kretzschmar HA, Griesinger C, Giese A, Fuhrmann M. 2015. Reducing tau aggregates with anle138b delays disease progression in a mouse model of tauopathies. Acta Neuropathologica. 130(5):619-631. https://doi.org/10.1007/s00401-015-1483-3

    Fuhrmann F, Justus D, Sosulina L, Kaneko H, Beutel T, Friedrichs D, Schoch S, Schwarz MK, Fuhrmann M, Remy S. 2015. Locomotion, Theta Oscillations, and the Speed-Correlated Firing of Hippocampal Neurons Are Controlled by a Medial Septal Glutamatergic Circuit. Neuron. 86(5):1253-1264. https://doi.org/10.1016/j.neuron.2015.05.001

    Qi Y, Klyubin I, Harney SC, Hu NW, Cullen WK, Grant MK, Steffen J, Wilson EN, Do Carmo S, Remy S, Fuhrmann M, Ashe KH, Cuello AC, Rowan MJ. 2014. Longitudinal testing of hippocampal plasticity reveals the onset and maintenance of endogenous human Aß-induced synaptic dysfunction in individual freely behaving pre-plaque transgenic rats: Rapid reversal by anti-Aß agents. Acta neuropathologica communications. 2(1):175. https://doi.org/10.1186/s40478-014-0175-x

    Šišková Z, Justus D, Kaneko H, Friedrichs D, Henneberg N, Beutel T, Pitsch J, Schoch S, Becker A, vonderKammer H, Remy S. 2014. Dendritic structural degeneration is functionally linked to cellular hyperexcitability in a mouse model of alzheimer's disease. Neuron. 84(5):1023-1033. https://doi.org/10.1016/j.neuron.2014.10.024

    Pothmann L, Müller C, Averkin RG, Bellistri E, Miklitz C, Uebachs M, Remy S, de la Prida LM, Beck H. 2014. Function of inhibitory micronetworks is spared by Na+ channel-acting anticonvulsant drugs. Journal of Neuroscience. 34(29):9720-9735. https://doi.org/10.1523/JNEUROSCI.2395-13.2014

    Müller C, Remy S. 2014. Dendritic inhibition mediated by O-LM and bistratified interneurons in the hippocampus. Frontiers in Synaptic Neuroscience. 6(SEP):23. https://doi.org/10.3389/fnsyn.2014.00023

    Müller C, Remy S. 2013. Fast micro-iontophoresis of glutamate and GABA: a useful tool to investigate synaptic integration. Journal of Visualized Experiments. (77). https://doi.org/10.3791/50701

    Müller C, Beck H, Coulter D, Remy S. 2012. Inhibitory Control of Linear and Supralinear Dendritic Excitation in CA1 Pyramidal Neurons. Neuron. 75(5):851-864. https://doi.org/10.1016/j.neuron.2012.06.025

    Krueppel R, Remy S, Beck H. 2011. Dendritic integration in hippocampal dentate granule cells. Neuron. 71(3):512-528. https://doi.org/10.1016/j.neuron.2011.05.043

    Chen S, Su H, Yue C, Remy S, Royeck M, Sochivko D, Opitz T, Beck H, Yaari Y. 2011. An increase in persistent sodium current contributes to intrinsic neuronal bursting after status epilepticus. Journal of Neurophysiology. 105(1):117-129. https://doi.org/10.1152/jn.00184.2010

    Park JY, Remy S, Varela J, Cooper DC, Chung S, Kang HW, Lee JH, Spruston N. 2010. A post-burst afterdepolarization is mediated by group I metabotropic glutamate receptor-dependent upregulation of Cav2.3 R-type calcium channels in CA1 pyramidal neurons. PLoS Biology. 8(11):e1000534. https://doi.org/10.1371/journal.pbio.1000534

    Remy S, Beck H, Yaari Y. 2010. Plasticity of voltage-gated ion channels in pyramidal cell dendrites. Current Opinion in Neurobiology. 20(4):503-509. https://doi.org/10.1016/j.conb.2010.06.006

    Remy S, Csicsvari J, Beck H. 2009. Activity-Dependent Control of Neuronal Output by Local and Global Dendritic Spike Attenuation. Neuron. 61(6):906-916. https://doi.org/10.1016/j.neuron.2009.01.032

    Royeck M, Horstmann MT, Remy S, Reitze M, Yaari Y, Beck H. 2008. Role of axonal NaV1.6 sodium channels in action potential initiation of CA1 pyramidal neurons. Journal of Neurophysiology. 100(4):2361-2380. https://doi.org/10.1152/jn.90332.2008

    Remy S, Spruston N. 2007. Dendritic spikes induce single-burst long-term potentiation. Proceedings of the National Academy of Sciences of the United States of America. 104(43):17192-17197. https://doi.org/10.1073/pnas.0707919104

    Remy S, Beck H. 2006. Molecular and cellular mechanisms of pharmacoresistance in epilepsy. Brain. 129(Pt 1):18-35. https://doi.org/10.1093/brain/awh682

    Heinemann U, Kann O, Remy S, Beck H. 2006. Novel mechanisms underlying drug resistance in temporal lobe epilepsy.Advances in neurology. 97:85-95.

    Yue C, Remy S, Su H, Beck H, Yaari Y. 2005. Proximal persistent Na+ channels drive spike afterdepolarizations and associated bursting in adult CA1 pyramidal cells. Journal of Neuroscience. 25(42):9704-9720. https://doi.org/10.1523/JNEUROSCI.1621-05.2005

    Remy C, Remy S, Beck H, Swandulla D, Hans M. 2004. Modulation of voltage-dependent sodium channels by the δ-agonist SNC80 in acutely isolated rat hippocampal neurons. Neuropharmacology. 47(7):1102-1112. https://doi.org/10.1016/j.neuropharm.2004.06.034

    Ellerkmann RK, Remy S, Chen J, Sochivko D, Elger CE, Urban BW, Becker A, Beck H. 2003. Molecular and functional changes in voltage-dependent Na+ channels following pilocarpine-induced status epilepticus in rat dentate granule cells. Neuroscience. 119(2):323-333. https://doi.org/10.1016/S0306-4522(03)00168-4

    Remy S, Urban BW, Elger CE, Beck H. 2003. Anticonvulsant pharmacology of voltage-gated Na+ channels in hippocampal neurons of control and chronically epileptic rats. European Journal of Neuroscience. 17(12):2648-2658. https://doi.org/10.1046/j.1460-9568.2003.02710.x

    Remy S, Gabriel S, Urban BW, Dietrich D, Lehmann TN, Elger CE, Heinemann U, Beck H. 2003. A novel mechanism underlying drug resistance in chronic epilepsy. Annals of Neurology. 53(4):469-479. https://doi.org/10.1002/ana.10473
  • Drittmittel

    Drittmittel

    2020 - 2024 (DFG)
    SFB 1436 TP A03: Neurale Ressourcenallokation durch räumliche Gedächtnisschaltung im Hinblick auf fortschreitende pathologische Herausforderungen
    https://sfb1436.de/

    2020 - 2022 (EU)
    SUBDECODE - Dendritic Dendritic encoding of movement in space 725693 - SUBDECODE - ERC-2016-COG

    2020 - 2021 (DFG)
    SFB 1089 TPB01: SFB 1089: Funktion synaptischer Mikronetzwerke und deren Störung bei Erkrankungen des Zentralnervensystems ,Teilprojekte B01 - Subkortikale Kontrolle neuronaler Aktivität im Hippokampus während der Lokomotion

    2020 - 2021 (DFG)
    SFB 1089/ TP C07: SFB 1089: Funktion synaptischer Mikronetzwerke und deren Störung bei Erkrankungen des Zentralnervensystems ,Teilprojekte C07 - Dendritische Mechanismen für Bildung von Merkmalselektivität in CA1 Neuronen und deren Beeinträchtigung bei Mausmodellen der Alzheimer-Krankheit

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