The Department Cellular Neurosciense will start new seminar series “NeuroCommunications”at LIN in 2023.
You are cordially invited to the first talk in the series by
Professor Dirk Isbrandt
Institute for Molecular and Behavioral Neuroscience
University of Cologne
Titled: Neurodevelopment-specific impairment in brain structure and function in mouse models of HCN/h channelopathies
January 9th, 3 pm - Ebbinghaus room
Abstract
The hyperpolarization-activated cyclic nucleotide-gated nonselective cation (HCN) channels mediate I(h) and are important determinants of the biophysical properties of neurons. Changes in expression patterns, subcellular localization, or biophysical characteristics of HCN channels have been associated with neurological dysfunctions ranging from motor learning deficits to neurological diseases such as epilepsy.
About the guest
My team and I seek to model the aspects of human HCN/h channel dysfunction by generating transgenic and knockin mouse lines. We specifically aim at identifying age- or developmental stage-specific effects of HCN/h channel dysfunction. I will present our findings demonstrating surprisingly distinct roles of HCN/h channels during pre-and postnatal CNS development. The different age-dependent developmental phenotypes observed in our mouse lines may provide a model to investigate the range and variability of neurological dysfunctions associated, e.g., with HCN1 mutations in human patients.
The presentation will be hosted by Dr. Liudmila Sosulina on behalf of the Department Cellular Neurosciense.
Don’t miss the chance to talk to Prof. Isbrandt during his visit to LIN [contact Liudmila (liudmila.sosulina(at)lin-magdeburg.de) to book a slot].
We are looking forward to your participation!